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Cited by 344Probiotics and Fermented FoodsGut microbiota and healthCancer Research and Treatments

Probiotic Bacteria: A Promising Tool in Cancer Prevention and Therapy

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Górska, Agata, Przystupski, Dawid, Niemczura, Magdalena J., Kulbacka, Julita·2019·Current Microbiology
DOI 10.1007/s00284-019-01679-8PMC PMC6586914
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Abstract

Gut microbiota is widely considered to be one of the most important components to maintain balanced homeostasis. Looking forward, probiotic bacteria have been shown to play a significant role in immunomodulation and display antitumour properties. Bacterial strains could be responsible for detection and degradation of potential carcinogens and production of short-chain fatty acids, which affect cell death and proliferation and are known as signaling molecules in the immune system. Lactic acid bacteria present in the gut has been shown to have a role in regression of carcinogenesis due to their influence on immunomodulation, which can stand as a proof of interaction between bacterial metabolites and immune and epithelial cells. Probiotic bacteria have the ability to both increase and decrease the production of anti-inflammatory cytokines which play an important role in prevention of carcinogenesis. They are also capable of activating phagocytes in order to eliminate early-stage cancer cells. Application of heat-killed probiotic bacteria coupled with radiation had a positive influence on enhancing immunological recognition of cancer cells. In the absence of active microbiota, murine immunity to carcinogens has been decreased. There are numerous cohort studies showing the correlation between ingestion of dairy products and the risk of colon and colorectal cancer. An idea of using probiotic bacteria as vectors to administer drugs has emerged lately as several papers presenting successful results have been revealed. Within the next few years, probiotic bacteria as well as gut microbiota are likely to become an important component in cancer prevention and treatment.

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Authors
Górska, A., Przystupski, D., Niemczura, M. J., & Kulbacka, J.
Affiliations
  • University of Wrocław (PL)
  • Wroclaw Medical University (PL)
Corresponding author
Przystupski, Dawid
ORCID
Venue
Current Microbiology
Publisher
Springer Science and Business Media LLC
Published
2019-04-04
Volume
76
Issue
8
Pages
939-949
ISSN
  • 0343-8651 (ISSN-L)
  • 1432-0991
DOI
10.1007/s00284-019-01679-8
PMC
PMC6586914
OpenAlex
W2926679877
Cited by
344
References
120
Citations by year
2026: 20 · 2025: 44 · 2024: 62 · 2023: 68 · 2022: 57 · 2021: 53 · 2020: 35 · 2019: 4
FWCI
3.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Ministerstwo Nauki i Szkolnictwa Wyższego (PO WER)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
Keywords
probiotic bacteria, gut microbiota, cancer prevention, cancer therapy, immunomodulation, short-chain fatty acids, lactic acid bacteria, carcinogenesis, anti-inflammatory cytokines, phagocyte activation, heat-killed bacteria, radiotherapy, colorectal cancer, dairy products
MeSH terms
Gastrointestinal Microbiome, Animals, Disease Models, Animal, Humans, Immunologic Factors, Colorectal Neoplasms, Probiotics, Mice, Dysbiosis

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