The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis
Open accessAbstract
The aim of this study was to systematically review and meta-analyze published data on the diagnostic performance of combined 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the detection of primary tumors in patients with cancer of unknown primary (CUP). A systematic search for relevant studies was performed of the PubMed/MEDLINE and Embase databases. Methodological quality of the included studies was assessed. Reported detection rates, sensitivities and specificities were meta-analyzed. Subgroup analyses were performed if results of individual studies were heterogeneous. The 11 included studies, comprising a total sample size of 433 patients with CUP, had moderate methodological quality. Overall primary tumor detection rate, pooled sensitivity and specificity of FDG-PET/CT were 37%, 84% (95% CI 78-88%) and 84% (95% CI 78-89%), respectively. Sensitivity was heterogeneous across studies (P = 0.0001), whereas specificity was homogeneous across studies (P = 0.2114). Completeness of diagnostic workup before FDG-PET/CT, location of metastases of unknown primary, administration of CT contrast agents, type of FDG-PET/CT images evaluated and way of FDG-PET/CT review did not significantly influence diagnostic performance. In conclusion, FDG-PET/CT can be a useful method for unknown primary tumor detection. Future studies are required to prove the assumed advantage of FDG-PET/CT over FDG-PET alone and to further explore causes of heterogeneity.
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Meta-DiSc: a software for meta-analysis of test accuracy data
Zamora, J., Abraira, V., Muriel, A., Khan, K., & Coomarasamy, A. (2006) · BMC Medical Research Methodology · doi:10.1186/1471-2288-6-31 · Cited by 1,883
Clinical Applications of PET in Oncology
Rohren, E. M., Turkington, T. G., & Coleman, R. E. (2004) · Radiology · doi:10.1148/radiol.2312021185 · Cited by 859
Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies
Whiting, P. F., Weswood, M. E., Rutjes, A. W., Reitsma, J. B., Bossuyt, P. N., & Kleijnen, J. (2006) · BMC Medical Research Methodology · doi:10.1186/1471-2288-6-9 · Cited by 769
Integrated PET/CT: Current Applications and Future Directions
von Schulthess, G. K., Steinert, H. C., & Hany, T. F. (2006) · Radiology · doi:10.1148/radiol.2382041977 · Cited by 619
Diagnostic and therapeutic management of cancer of an unknown primary
Pavlidis, N., Briasoulis, E., Hainsworth, J., & Greco, F. A. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00547-1 · Cited by 597
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Self-citationBlodgett, T. M., Meltzer, C. C., & Townsend, D. W. (2007) · Radiology · doi:10.1148/radiol.2422051113 · Cited by 387
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Focal tracer uptake: a potential artifact in contrast-enhanced dual-modality PET/CT scans.
Antoch, G., Freudenberg, L. S., Egelhof, T., Stattaus, J., Jentzen, W., Debatin, J. F., & Bockisch, A. (2002) · PubMed · Cited by 201
Metadata
- Authors
- Kwee, T. C., & Kwee, R. M.
- Venue
- European Radiology
- Published
- 2008-10-17
- Volume
- 19
- Issue
- 3
- Pages
- 731-744
- ISSN
- 0938-7994 (ISSN-L)
- 1432-1084
- OpenAlex
- W2062915447
- Cited by
- 317
- References
- 26
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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