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Cited by 3Colorectal Cancer Surgical TreatmentsColorectal Cancer Screening and DetectionGastric Cancer Management and Outcomes

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The effect of preoperative endoscopic tattooing on lymph node retrieval in colorectal cancer: a systematic review and meta-analysis

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Nawras, Mohamad, Chawla, Karan, DeRiso, Armelle, Dubchuk, Christina, Beran, Azizullah, Aziz, Muhammad, Pannell, Stephanie M.·2023·International Journal of Colorectal Disease
DOI 10.1007/s00384-023-04466-x

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Abstract

Purpose The effect of preoperative endoscopic tattooing (ET) on accurate colorectal cancer localization and resection has been well established. However, its effect on lymph node (LN) retrieval remains unclear. The purpose of this study was to systematically compare LN retrieval between patients with colorectal cancer who underwent preoperative ET and those who did not. Methods A systematic search for relevant studies was conducted using the following databases: PubMed, Embase, and Web of Science. Studies that compared LN retrieval in patients with colorectal cancer with and without preoperative ET were included. Weighted pooled odds ratio (OR) and mean difference (MD) with the corresponding 95% confidence intervals (CIs) for all outcomes using the random-effects model were calculated. Results 10 studies, including 2231 patients with colorectal cancer were included. Six studies reported total LN yield and showed significantly higher LN yield in the tattooed group (MD:2.61; 95% CI:1.01-4.21, P=0.001). Seven studies reported the number of patients with adequate LN retrieval and showed a significantly higher number of patients with adequate LN retrieval in the tattooed group (OR:1.89, 95% CI:1.08-3.32, P=0.03). However, subgroup analysis revealed that both outcomes were only statistically significant in patients with rectal cancer, and not in patients with colon cancer. Conclusions Our results suggest that preoperative ET is associated with increased LN retrieval in patients with rectal cancer, but not in colon cancer. Further large-scale randomized control trials are necessary to validate our findings.

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Metadata

Authors
Nawras, M., Chawla, K., DeRiso, A., Dubchuk, C., Beran, A., Aziz, M., & Pannell, S. M.
Affiliations
  • University of Toledo (US)
  • Indiana University School of Medicine (US)
Corresponding author
Nawras, Mohamad
ORCID
Venue
International Journal of Colorectal Disease
Publisher
Springer Science and Business Media LLC
Published
2023-06-09
Volume
38
Issue
1
Pages
166-166
ISSN
  • 0179-1958 (ISSN-L)
  • 1432-1262
DOI
10.1007/s00384-023-04466-x
OpenAlex
W4379967500
Cited by
3
References
35
Citations by year
2026: 1 · 2025: 2
FWCI
0.10
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Colorectal Disease (publishedVersion)
  • Research Square (acceptedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
Keywords
endoscopic tattooing, lymph node yield, colorectal cancer, rectal cancer, colon cancer, surgical resection
MeSH terms
Colonic Neoplasms, Humans, Lymph Node Excision, Lymph Nodes, Preoperative Care, Rectal Neoplasms, Retrospective Studies, Tattooing, Colorectal Neoplasms

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