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Cited by 632

The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.

NAFLD and cardiovascular diseases: a clinical review

Open access
Kasper, Philipp, Martin, Anna, Lang, Sonja, Kütting, Fabian, Goeser, Tobias, Demir, Münevver, Steffen, Hans-Michael·2021·Clinical Research in Cardiology

Abstract

Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in Western countries and affects approximately 25% of the adult population. Since NAFLD is frequently associated with further metabolic comorbidities such as obesity, type 2 diabetes mellitus, or dyslipidemia, it is generally considered as the hepatic manifestation of the metabolic syndrome. In addition to its potential to cause liver-related morbidity and mortality, NAFLD is also associated with subclinical and clinical cardiovascular disease (CVD). Growing evidence indicates that patients with NAFLD are at substantial risk for the development of hypertension, coronary heart disease, cardiomyopathy, and cardiac arrhythmias, which clinically result in increased cardiovascular morbidity and mortality. The natural history of NAFLD is variable and the vast majority of patients will not progress from simple steatosis to fibrosis and end stage liver disease. However, patients with progressive forms of NAFLD, including non-alcoholic steatohepatitis (NASH) and/or advanced fibrosis, as well as NAFLD patients with concomitant types 2 diabetes are at highest risk for CVD. This review describes the underlying pathophysiological mechanisms linking NAFLD and CVD, discusses the role of NAFLD as a metabolic dysfunction associated cardiovascular risk factor, and focuses on common cardiovascular manifestations in NAFLD patients.

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Metadata

Authors
Kasper, P., Martin, A., Lang, S., Kütting, F., Goeser, T., Demir, M., & Steffen, H.-M.
Venue
Clinical Research in Cardiology
Published
2020-07-21
Volume
110
Issue
7
Pages
921-937
ISSN
  • 1861-0684 (ISSN-L)
  • 1861-0692
OpenAlex
W3044005771
Cited by
632
References
171
FWCI
47.77
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: NAFLD and cardiovascular diseases: a clinical review. https://app.cochat.ai/papers/10.1007/s00392-020-01709-7
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Kasper, P., Martin, A., Lang, S., Kütting, F., Goeser, T., Demir, M., & Steffen, H.-M. (2021). NAFLD and cardiovascular diseases: a clinical review. Clinical Research in Cardiology. https://doi.org/10.1007/s00392-020-01709-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.