Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion
Open accessAbstract
Purpose To investigate the relation between pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion (SAB).Methods Our prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009). Beverage intake was assessed every 4 years using a validated questionnaire. Pregnancies were self-reported with case pregnancies lost spontaneously at <20 weeks gestation. Multivariable log-binomial regression models with generalized estimating equations were used to estimate the relative risks (RRs) and 95 % confidence intervals (CIs).Results There was a positive linear trend across categories of pre-pregnancy caffeine intake and risk of SAB such that women consuming >400 mg/day had 1.11 (95 % CI 0.98, 1.25) times the risk of SAB compared to women consuming <50 mg/day (p trend = 0.05). Total coffee intake had a positive, linear association with SAB. Compared to women with no pre-pregnancy coffee intake, women consuming ≥4 servings/day had a 20 % (6, 36 %) increased risk of SAB (p trend = 0.01). There was no difference in the association between caffeinated and decaffeinated coffee and risk of SAB. Pre-pregnancy intake of caffeinated tea, caffeinated soda, and decaffeinated soda had no association with SAB.Conclusions Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with increased risk of SAB, particularly at weeks 8-19.
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Pre-pregnancy consumption of more than 400 mg of caffeine/day increases the risk of spontaneous abortion by 11% compared with women who consumed less than 50 mg/day.
“pre-pregnancy consumption of >400 mg of caffeine/day increasing the risk of spontaneous abortion by 11% compared with women who consumed <50 mg of caffeine/day (131).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [131]
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References 47 · Cited by 55
Research works printed but not linked: 1
- [46]The American Congress of Obstetricia ns and Gynecologists (ACOG) Committee Opinion No. 462: Moderate caffeine consumption during pregnancy Obstet Gynecol 2010 116 2 Pt 1 467 468 20664420
- Authors
- Gaskins, A. J., Rich-Edwards, J. W., Williams, P. L., Toth, T. L., Missmer, S. A., & Chavarro, J. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Gaskins, Audrey J.
- Venue
- European Journal of Nutrition
- Published
- 2016-08-29
- Volume
- 57
- Issue
- 1
- Pages
- 107-117
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- PMC
- PMC5332346
- OpenAlex
- W2515400955
- Cited by
- 55
- References
- 47
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 6
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007703-16, P30DK46200)
- National Cancer Institute (UM1CA176726)
- National Institute of Child Health and Human Development (L50-HD085359)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- caffeine consumption, caffeinated beverages, coffee consumption, miscarriage, pre-pregnancy diet, decaffeinated coffee, caffeine dose-response, Nurses' Health Study II
- MeSH terms
- Abortion, Spontaneous, Adult, Beverages, Caffeine, Carbonated Beverages, Coffee, Diet, Female, Gestational Age, Humans, Pregnancy, Prospective Studies, Surveys and Questionnaires, Risk Factors, Tea, Body Mass Index, Preconception Care
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