The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Primary age-related tauopathy (PART): a common pathology associated with human aging
Open accessAbstract
We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer's disease (AD), in the absence of amyloid (Aβ) plaques. For these "NFT+/Aβ-" brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as "tangle-only dementia" and "tangle-predominant senile dementia", are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Perivascular, subpial, and periventricular p-tau immunoreactive NFTs and astrocytic tangles in the neocortex have been reported to be characteristic of both primary age-related tauopathy (PART) [35] and age-related tau astrogliopathy (ARTAG) [36].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [35]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Primary age-related tauopathy (PART) and aging-related tau astrogliopathy (ARTAG) are independent tau pathologies commonly observed in patients over 80 years of age, and PART may account for a proportion of the misdiagnosed clinical AD cases in the elderly [130, 141, 142].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [142]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Lesions are found in the hippocampus and adjacent regions similar to those observed in Braak I-IV, but PART is distinct from AD in that it lacks amyloid plaques, and it has distinct morbidity and age range [130, 142].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [142]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“PART refers to neuronal tau pathology and ARTAG is characterized by astrocytic tau pathology, although they are not mutually exclusive, and appear to be more a manifestation of age than a subtype of neurodegenerative disease.”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [35]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Many studies, from the histopathology of Braak and Braak4 to longitudinal studies of Tau positron emission tomography imaging27,28, demonstrate that MTG is a transition zone between aging-related or preclinical AD-related medial temporal lobe pTau and more advanced stages of AD, where neocortical pTau extends across the brain and is strongly correlated with dementia4,29–31.”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [29]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It should be noted that tau aggregation in the brain is associated with older age and is generally uncommon in healthy young adults (Braak et al., 2011; Crary et al., 2014).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Crary et al., 2014
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“LATE and PART are common neuropathologies, indicating the importance of addressing potential relationships between AD-Mimics, and LATE and PART pathology in future research (20,22).”
From Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy (2020) · cites this paper as [22]
The cited source says what the claim attributes to it.
In the citing paper
“AD-Mimics and definite PART are both defined as having no neuritic plaques, and like the AD-Mimics in this study, PART participants are generally older and experience less severe cognitive dysfunction (22,23).”
From Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy (2020) · cites this paper as [22]
The cited source says what the claim attributes to it.
In the citing paper
“The compact NFTs observed are morphologically most like those seen in primary age-related tauopathy (PART) [4], Alzheimer’s disease (AD) [22], and chronic traumatic encephalopathy (CTE) [13, 14], but the topographical distribution and immunostaining characteristics differ from these more common tauopathies in several respects.”
From Tuberous sclerosis complex is associated with a novel human tauopathy (2023) · cites this paper as [4]
In the citing paper
“APOE4 significantly aggravated tau-mediated neurodegeneration in a tauopathy mouse model and induced tau aggregates in brain, while genetic ablation of APOE attenuated tau-induced neurodegeneration [469, 470].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [470]
In the citing paper
“In AD and PART, the tau aggregates are a mixture of three-repeat and four-repeat tau isoforms, whereas four-repeat sequences dominate in PSP and CBD and three-repeat sequences predominate in Pick disease14,18,19,21.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [14]
In the citing paper
“More recently, Crary et al. coined the term “primary age-related tauopathy” (PART) after observing that the postmortem brains of many elderly individuals harbor NFTs indistinguishable from those of AD but in the absence of Aβ plaques or cognitive decline [44].”
From Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau (2021) · cites this paper as [44]
In the citing paper
“The panel did not ultimately accept all of the a priori criteria for CTE; they did not include pathology known to be associated with aging (i.e.primary age-related tauopathy [PART] [16] and aging-related tau astrogliopathy [ARTAG] [17]).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Self-citationNeuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498
Self-citationBraak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172
Self-citationHyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092
Self-citationMontine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,894 · cited 3×
“the current guidelines for AD [64, 102], mild Aβ plaques”
BackgroundInfluentialSelf-citationConsortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357
Flagged first, then by citations
Cited by
Sorted by citations
Items 801–900 of 1,002
Paasila, P. J., Davies, D., Sutherland, G. T., & Goldsbury, C. S. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-2845 · Cited by 16
Tripathy, A., Shade, A., Erskine, B., Bailey, K., Grande, A. J., deLong, J. J., Perry, G. L., & Castellani, R. J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181039 · Cited by 16
Tuberous sclerosis complex is associated with a novel human tauopathy
Hwang, J.-H. L., Perloff, O. S., Gaus, S. E., Benitez, C., Alquezar, C., Cosme, C. Q., Nana, A. L., Vatsavayai, S. C., Ramos, E. M., Geschwind, D. H., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-022-02521-5 · Cited by 15
Self-citationCognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies
Almeida, F., Marx, G. A., Rohde, S. K., Gonzales, M. M., Maldonado‐Díaz, C., Hiya, S., Clare, K. M., Samanamud, J. L., Slocum, C., Kauffman, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70575 · Cited by 15
Self-citationCerebrovascular disease in suspected non‐Alzheimer's pathophysiology and cognitive decline over time
Saridin, F. N., Chew, K. A., Reilhac, A., Gyanwali, B., Villaraza, S. G., Tanaka, T., Scheltens, P., van der Flier, W. M., Chen, C., & Hilal, S. (2022) · European Journal of Neurology · doi:10.1111/ene.15337 · Cited by 15
Molecular differences in brain regional vulnerability to aging between males and females
Zhou, X., Cao, J., Zhu, L., Farrell, K. W., Wang, M., Guo, L., Yang, J., McKenzie, A. T., Crary, J. F., Cai, D., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1153251 · Cited by 16
Self-citationTau trajectory in Alzheimer’s disease: Evidence from the connectome-based computational models
Bitra, V. R., Challa, S. R., Adiukwu, P. C., & Rapaka, D. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110777 · Cited by 15
He, K., Li, B., Huang, L., Zhao, J., Hua, F., Wang, T., Li, J., Wang, J., Huang, Q., Chen, K., et al. (2023) · European Radiology · doi:10.1007/s00330-023-10366-z · Cited by 15
Ethnic differences in the prevalence of amyloid positivity and cognitive trajectories
Jang, H., Chun, M. Y., Yun, J., Kim, J. P., Kang, S. H., Weiner, M. W., Kim, H. J., Na, D. L., Hong, C., Son, S. J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14247 · Cited by 15
Alafuzoff, I. I. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00010-4 · Cited by 15
Self-citationKothapalli, S. V. V. N., Benzinger, T. L. S., Aschenbrenner, A. J., Perrin, R. J., Hildebolt, C. F., Goyal, M. S., Fagan, A. M., Raichle, M. E., Morris, J. C., & Yablonskiy, D. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210503 · Cited by 15
Diagnosis of coexistent neurodegenerative dementias in multiple sclerosis
Londoño, D., Arumaithurai, K., Constantopoulos, E., Basso, M. R., Reichard, R. R., Flanagan, E. P., & Keegan, B. M. (2022) · Brain Communications · doi:10.1093/braincomms/fcac167 · Cited by 15
Medial temporal tau predicts memory decline in cognitively unimpaired elderly
Kwan, A. T. H., Arfaie, S., Therriault, J., Azizi, Z., Lussier, F. Z., Tissot, C., Chamoun, M., Bezgin, G., Servaes, S., Stevenon, J., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac325 · Cited by 15
Tau accumulation in autosomal dominant Alzheimer’s disease: a longitudinal [18F]flortaucipir study
O’Connor, A., Cash, D. M., Poole, T., Markiewicz, P. J., Fraser, M. R., Malone, I. B., Jiao, J., Weston, P. S. J., Flores, S. E., Hornbeck, R. C., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01234-5 · Cited by 15
Hohman, T. J., Dumitrescu, L. C., Oksol, A., Wagener, M. A., Gifford, K. A., Jefferson, A. L., & Initiative, A. D. N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188501 · Cited by 15
Shigemoto, Y., Sone, D., Imabayashi, E., Maikusa, N., Okamura, N., Furumoto, S., Kudo, Y., Ogawa, M., Takano, H., Yokoi, Y., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00223 · Cited by 15
The influence of β-amyloid on [ 18 F]AV-1451 in semantic variant of primary progressive aphasia
Whitwell, J. L., Martin, P. R., Duffy, J. R., Clark, H. M., Machulda, M. M., Schwarz, C. G., Weigand, S. D., Sintini, I., Senjem, M. L., Ertekin‐Taner, N., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000006913 · Cited by 15
Self-citationAstrocytic tau pathologies in aged human brain
Okamoto, K., Amari, M., Fukuda, T., Suzuki, K., & Takatama, M. (2019) · Neuropathology · doi:10.1111/neup.12544 · Cited by 15
Verheijen, B. M., Lussier, C., Müller-Hübers, C., Garruto, R. M., Oyanagi, K., Braun, R. J., & van Leeuwen, F. W. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz110 · Cited by 15
Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: The Hisayama Study
Hamasaki, H., Honda, H., Okamoto, T., Koyama, S., Suzuki, S. O., Ohara, T., Ninomiya, T., Kiyohara, Y., & Iwaki, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160521 · Cited by 15
Agoston, D. V., Arun, P., Bellgowan, P. S. F., Broglio, S. P., Cantu, R. C., Cook, D. G., da Silva, U. O., Dickstein, D. L., Elder, G. A., Fudge, E., et al. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5220 · Cited by 15
Brain Atrophy on Magnetic Resonance Imaging as a Biomarker of Neurodegeneration
Jack, C. R. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2843 · Cited by 15
Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?
Durcan, R., O’Callaghan, C., & Rowe, J. B. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf310 · Cited by 15
Bathe, T., Hery, G. P., Villareal, J. A. B., Phillips, J. L., Cohen, E. M., Sharma, R. V., Tsering, W., & Prokop, S. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01770-7 · Cited by 15
Youssef, H., Gatto, R. G., Pham, N. T. T., Petersen, R. C., Machulda, M. M., Reichard, R. R., Dickson, D. W., Jack, C. R., Whitwell, J. L., & Josephs, K. A. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240136 · Cited by 14
Self-citationFGFR3 drives Aβ-induced tau uptake
Kim, D. K., Suh, K. Y., Park, J., Lee, S., Han, J., Chang, S., Kim, Y., & Mook‐Jung, I. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01274-3 · Cited by 14
Hiya, S., Maldonado‐Díaz, C., Rohde, S. K., Gonzales, M. M., Canbeldek, L., Mahadevan, L. S. K., Yokoda, R. T., Sullivan, A. C., Parker, A. S., White, C. L., et al. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae134 · Cited by 14
Self-citationApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease
Lennol, M. P., Bordier, C., Kamelher, L., Ulrich, J. D., Holtzman, D. M., & Gratuze, M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20250965 · Cited by 14
Tan, R. H., Yang, Y., & Halliday, G. M. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12455 · Cited by 14
Chronic Traumatic Encephalopathy Pathology After Shotgun Injury to the Brain
Tribett, T., Erskine, B., Bailey, K., Brown, T. T., & Castellani, R. J. (2019) · Journal of Forensic Sciences · doi:10.1111/1556-4029.14001 · Cited by 14
Recent advances in pre-clinical diagnosis of Alzheimer’s disease
Zhou, J., Benoit, M., & Sharoar, M. G. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00733-4 · Cited by 14
Zebrafish Models to Study New Pathways in Tauopathies
Barbereau, C., Cubedo, N., Maurice, T., & Rossel, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094626 · Cited by 14
Shiino, A., Shirakashi, Y., Ishida, M., Tanigaki, K., & Initiative, J. A. D. N. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12246 · Cited by 14
Ozaki, K., Irioka, T., Uchihara, T., Yamada, A., Nakamura, A., Majima, T., Igarashi, S., Shintaku, H., Yakeishi, M., Tsuura, Y., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01272-w · Cited by 14
Ge, X., Initiative, A. D. N., Qiao, Y., Choi, J., Raman, R., Ringman, J. M., & Shi, Y. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215555 · Cited by 14
Almeida, F., Jesus, T., Coelho, A., Quintas-Neves, M., Gauthreaux, K. M., Teylan, M., Mock, C., Kukull, W. A., Crary, J. F., & Oliveira, T. G. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.02.013 · Cited by 14
Self-citationVery old onset parkinsonism: A clinical-pathological study
Jellinger, K. A. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2018.07.015 · Cited by 14
Self-citationDoes early cognitive decline require the presence of both tau and amyloid-β?
Schöll, M., & Maaß, A. (2019) · Brain · doi:10.1093/brain/awz399 · Cited by 14
Ferrer, I., Andrés‐Benito, P., Sala‐Jarque, J., Gil, V., & del Rı́o, J. A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00101 · Cited by 14
Zádori, D., Szalárdy, L., Reisz, Z., Kovács, G. G., Maszlag-Török, R., Ajeawung, N. F., Vécsei, L., Campeau, P. M., & Klivènyi, P. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00767 · Cited by 14
Antemortem Prediction of Braak Stage
Carlson, J. O. E., Gatz, M., Pedersen, N. L., Graff, C., Nennesmo, I., Lindström, A.-K., & Gerritsen, L. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000251 · Cited by 14
Anti-Correlated Cerebrospinal Fluid Biomarker Trajectories in Preclinical Alzheimer’s Disease
Gomar, J. J., Conejero-Goldberg, C., Davies, P., Goldberg, T. E., & Initiative, F. T. A. D. N. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150937 · Cited by 13
MAP2 caps tau fibrils and inhibits aggregation
Holden, M. R., Krzesinski, B. J., Weismiller, H. A., Shady, J. R., & Margittai, M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104891 · Cited by 13
Singhaarachchi, P. H., Antal, P., Calon, F., Culmsee, C., Delpech, J.-C., Feldotto, M., Geertsema, J., Hoeksema, E. E., Kőrösi, A., Layé, S., et al. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102821 · Cited by 13
Tomé, S. O., Gawor, K., Ospitalieri, S., Ronisz, A., Otto, M., Arnim, C. A. F. V., Ghebremedhin, E., Laureyssen, C., Sleegers, K., Vandenberghe, R. R., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02929-9 · Cited by 13
Self-citationLavrova, A., Pham, N. T. T., Vernon, C. J., Carlos, A. F., Petersen, R. C., Dickson, D. W., Lowe, V. J., Jack, C. R., Whitwell, J. L., & Josephs, K. A. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12312-5 · Cited by 13
Self-citationSilbert, L. C., Roese, N. E., Krajbich, V., Hurworth, J., Lahna, D. L., Schwartz, D. L., Dodge, H. H., & Woltjer, R. L. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13816 · Cited by 13
Self-citationYao, Y., Muench, M., Alle, T., Zhang, B., Lucero, B., Perez‐Tremble, R., McGrosso, D., Newman, M., Gonzalez, D. J., Lee, V. M. ‐., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13875 · Cited by 13
Soleimani‐Meigooni, D. N., Smith, R. A., Provost, K., Lesman‐Segev, O. H., Allen, I. E., Chen, M. K., Cho, H., Edwards, L., Janelidze, S., Joie, R. L., et al. (2024) · Annals of Neurology · doi:10.1002/ana.27008 · Cited by 13
Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration
Majumder, M., & Dutta, D. (2024) · Cells · doi:10.3390/cells13131112 · Cited by 14
Casteele, T. V., Laroy, M., Cauwenberge, M. G. A. V., Vanderlinden, G., Vansteelandt, K., Koole, M. J. B., Dupont, P. J., Bossche, M. J. A. V. D., den Stock, J. V., Bouckaert, F., et al. (2024) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2024.07.005 · Cited by 13
Bentivenga, G. M., Baiardi, S., Mastrangelo, A., Ruggeri, E., Mammana, A., Ticca, A., Rossi, M., Capellari, S., & Parchi, P. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01565-x · Cited by 13
Genetics and Neuropathology of Neurodegenerative Dementias
Scholz, S. W., & Cobos, I. (2024) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001505 · Cited by 13
Huang, K., Hsiao, I., Huang, C., Huang, C., Chang, H., Huang, S., Lin, K., Ma, M.-C., Huang, C., & Chang, C. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14297 · Cited by 13
Asken, B. M., Curiel, R. E., Crocco, E., Armstrong, M. J., Levy, S.-A. T., Arias, F., Rosselli, M., Vélez-Uribe, I., Barker, W., Matusz, E. F., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2024.100011 · Cited by 14
Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
Shi, Y., Tu, T., Jiang, J., Zhang, Q., Ai, J.-Q., Pan, A., Manavis, J., Tu, E., & Yan, X. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.596894 · Cited by 14
Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies
Kim, S. H., Farrell, K. W., Cosentino, S., Vonsattel, J., Faust, P. L., Cortes, E. P., Bennet, D. A., Louis, E. D., & Crary, J. F. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab073 · Cited by 13
Self-citationSalcedo‐Arellano, M. J., Sanchez, D., Wang, J. Y., McLennan, Y. A., Clark, C. J., Juárez, P., Schneider, A., Tassone, F., Hagerman, R. J., & Martínez‐Cerdeño, V. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.720253 · Cited by 13
Image-level trajectory inference of tau pathology using variational autoencoder for Flortaucipir PET
Hong, J., Kang, S. K., Alberts, I., Lu, J., Sznitman, R., Lee, J. S., Rominger, A., Choi, H., Shi, K., & Initiative, T. A. D. N. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05662-z · Cited by 13
Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta
Weigand, A. J., Edwards, L., Thomas, K. R., Bangen, K. J., Bondi, M. W., & Initiative, A. D. N. (2022) · Brain Communications · doi:10.1093/braincomms/fcac272 · Cited by 13
Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies
Fiock, K. L., Betters, R. K., & Hefti, M. M. (2023) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554231158428 · Cited by 13
Multiple system atrophy with amyloid-β-predominant Alzheimer’s disease neuropathologic change
Kon, T., Ichimata, S., Luca, D. G. D., Martínez-Valbuena, I., Kim, A., Yoshida, K., Alruwaita, A. A., Kleiner, G., Strafella, A. P., Forrest, S. L., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae141 · Cited by 13
Chronic traumatic encephalopathy: A paradigm in search of evidence?
Castellani, R. J. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.54 · Cited by 13
Dani, M., Wood, M., Mizoguchi, R., Fan, Z., Edginton, T. L., Hinz, R., Win, Z., Brooks, D. J., & Edison, P. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181168 · Cited by 13
Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays
Manca, M., & Kraus, A. (2020) · Biomolecules · doi:10.3390/biom10091233 · Cited by 13
Arber, C., Alatza, A., Leckey, C. A., Paterson, R. W., Zetterberg, H., & Wray, S. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15315 · Cited by 13
Kim, M., Kim, S. J., Park, J. E., Yun, J., Shim, W. H., Oh, J. S., Oh, M., Roh, J. H., Seo, S. W., Oh, S. J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89797-x · Cited by 13
Strauß, T., Marvian, A. T., Sadikoglou, E., Dhingra, A., Wegner, F., Trümbach, D., Wurst, W., Heutink, P., Schwarz, S. C., & Höglinger, G. U. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.726866 · Cited by 13
Amyloid‐dependent and amyloid‐independent effects of Tau in individuals without dementia
Therriault, J., Pascoal, T. A., Sefranek, M., Mathotaarachchi, S. S., Benedet, A. L., Chamoun, M., Lussier, F. Z., Tissot, C., Bellaver, B., Ferreira, P. L., et al. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51457 · Cited by 13
Goudsmit, J. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0144-8 · Cited by 13
Hayashi, H., Kobayashi, R., Kawakatsu, S., Ohba, M., Morioka, D., & Otani, K. (2021) · Psychogeriatrics · doi:10.1111/psyg.12729 · Cited by 13
Attems, J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1723-9 · Cited by 13
Self-citationDaulatzai, M. A. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9528-x · Cited by 12
Emeršič, A., Ashton, N. J., Vrillon, A., Lantero‐Rodriguez, J., Mlakar, J., Kramberger, M. G., González‐Ortiz, F., Kac, P. R., Dulewicz, M., Hanrieder, J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13907 · Cited by 12
2024 AA criteria for Alzheimer's disease diagnosis: Mainly anchored at Aβ not tau
Moscoso, A., & Villain, N. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14340 · Cited by 12
BOLD amplitude correlates of preclinical Alzheimer’s disease
Hrybouski, S., Das, S. R., Xie, L., Brown, C., Flamporis, M., Lane, J., Nasrallah, I. M., Detre, J. A., Yushkevich, P. A., & Wolk, D. A. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.03.007 · Cited by 13
Hojjati, S. H., Chiang, G. C.-Y., Butler, T., Chen, K., Khalafi, M., Yazdi, B. G., Foldi, N. S., Nayak, S., de Leon, M. J., Li, Y., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70153 · Cited by 12
Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD
Bryant, A. G., Manhard, M. K., Salat, D. H., Rosen, B. R., Hyman, B. T., Johnson, K. A., Huang, S. Y., Bennett, R. E., & Yen, Y. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211126113904 · Cited by 12
Self-citationNeocortical Neurofibrillary Degeneration in Primary Age-Related Tauopathy
Walker, J. M., White, C. L., Farrell, K. W., Crary, J. F., & Richardson, T. E. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab113 · Cited by 12
Self-citationten Donkelaar, H. J., Insausti, R., van Domburg, P., Küsters, B., Hashizume, Y., & Hori, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-41878-6_14 · Cited by 12
Wischhof, L., Adhikari, A., Mondal, M., Marsal-Cots, A., Biernat, J., Mandelkow, E., Mandelkow�, E., Ehninger, D., Nicotera, P., & Bano, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101774 · Cited by 12
Yokota, O., Miki, T., Ishizu, H., Haraguchi, T., Kishimoto, Y., Takenoshita, S., Hara, N., Miyashita, A., Ikeuchi, T., Terada, S., et al. (2022) · Neuropathology · doi:10.1111/neup.12820 · Cited by 12
Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy
Morris, M., Coste, G. I., Redding‐Ochoa, J., Guo, H., Graves, A. R., Troncoso, J. C., & Huganir, R. L. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad064 · Cited by 12
Self-citationGiaccone, G. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150435 · Cited by 12
Quenon, L., Dricot, L., Woodard, J. L., Hanseeuw, B. J., Gilis, N., Lhommel, R., & Ivanoiu, A. (2016) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617716000813 · Cited by 12
Khan, R. I., Nirzhor, S. S. R., & Rashid, B. (2018) · Brain Sciences · doi:10.3390/brainsci8090162 · Cited by 12
Bocai, N. I., Marcora, M. S., Belfiori-Carrasco, L. F., Morelli, L., & Castaño, E. M. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181021 · Cited by 12
Chen, D., Latimer, C. S., Spencer, M. W., Karna, P., Gonzalez‐Cuyar, L. F., Davis, M. Y., Keene, C. D., Bird, T. D., & Raskind, W. H. (2019) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12873 · Cited by 12
Molecular PET Imaging in Alzheimer’s Disease
Thientunyakit, T., Shiratori, S., Ishii, K., & Gelovani, J. G. (2022) · Journal of Medical and Biological Engineering · doi:10.1007/s40846-022-00717-4 · Cited by 12
Ultra-Early Phase pathologies of Alzheimer’s disease and other neurodegenerative diseases
Okazawa, H. (2017) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.93.022 · Cited by 12
Cognitive function in very old men does not correlate to biomarkers of Alzheimer’s disease
Veličkaitė, V., Giedraitis, V., Ström, K., Alafuzoff, I. I., Zetterberg, H., Lannfelt, L., Kilander, L., Larsson, E., & Ingelsson, M. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0601-6 · Cited by 12
Self-citationWu, Q., Han, D., Zhang, J., & Li, X. (2019) · Neurological Research · doi:10.1080/01616412.2019.1580456 · Cited by 12
Lachén-Montes, M., Mendizuri, N., Ausín, K., Pérez-Mediavilla, A., Azkargorta, M., Iloro, I., Elortza, F., Kondo, H., Ohigashi, I., Ferrer, I., et al. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00452 · Cited by 12
Yokota, O., Miki, T., Nakashima‐Yasuda, H., Ishizu, H., Haraguchi, T., Ikeda, C., Hasegawa, M., Miyashita, A., Ikeuchi, T., Nishikawa, N., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01828-6 · Cited by 11
Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer’s Disease
Tredici, K. D., Schön, M., Feldengut, S., Ghebremedhin, E., Kaufman, S. K., Wiesner, D., Roselli, F., Mayer, B., Amunts, K., & Braak, H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240483 · Cited by 11
Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice
Nagata, K., Hashimoto, S., Joho, D., Fujioka, R., Matsuba, Y., Sekiguchi, M., Mihira, N., Motooka, D., Liu, Y., Okuzaki, D., et al. (2024) · eNeuro · doi:10.1523/eneuro.0260-24.2024 · Cited by 11
Richardson, T. E., Orr, M. E., Orr, T. C., Rohde, S. K., Ehrenberg, A. J., Thorn, E. L., Christie, T. D., Almazan, V. F., Afzal, R., Sanctis, C. D., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14487 · Cited by 11
Self-citationTau biomarkers for neurodegenerative diseases: Current state and perspectives
Vacchi, E., Ruíz‐Barrio, I., & Melli, G. (2025) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2025.107772 · Cited by 11
Jiang, J., Yang, C. G., Ai, J.-Q., Zhang, Q., Cai, X.-L., Tu, T., Wan, L., Wang, X., Wang, H., Pan, A., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.926904 · Cited by 11
Zhao, Z., Zhang, L., Luo, W., Cao, Z., Zhu, Q., Kong, X., Zhu, K., Zhang, J., & Wu, D. (2022) · Human Brain Mapping · doi:10.1002/hbm.26062 · Cited by 11
Metadata
- Authors
- Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Gearing, M., Grinberg, L. T., Hof, P. R., Hyman, B. T., Jellinger, K., Jicha, G. A., Kovacs, G. G., Knopman, D. S., Kofler, J., Kukull, W. A., Mackenzie, I. R., Masliah, E., McKee, A., Montine, T. J., Murray, M. E., Neltner, J. H., Santa-Maria, I., Seeley, W. W., Serrano-Pozo, A., Shelanski, M. L., Stein, T., Takao, M., Thal, D. R., Toledo, J. B., Troncoso, J. C., Vonsattel, J. P., White, C. L., Wisniewski, T., Woltjer, R. L., Yamada, M., & Nelson, P. T.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of Pennsylvania (US)
- Rush University Medical Center (US)
- University of Kentucky (US)
- Uppsala University (SE)
- Newcastle University (GB)
- Banner Sun Health Research Institute (US)
- Northwestern University (US)
- Washington University in St. Louis (US)
- Mayo Clinic (US)
- Emory University (US)
- Universidade de São Paulo (BR)
- Icahn School of Medicine at Mount Sinai (US)
- Harvard University (US)
- University of Pittsburgh Medical Center (US)
- University of Washington (US)
- University of British Columbia (CA)
- University of California San Diego (US)
- Boston University (US)
- University of California, San Francisco (US)
- Tokyo Metropolitan Geriatric Hospital (JP)
- Universität Ulm (DE)
- The University of Texas Southwestern Medical Center (US)
- Oregon Health & Science University (US)
- Kanazawa University (JP)
- Corresponding author
- Crary, John F.
- Nelson, Peter T.
- ORCID
- Crary, John F.
- Trojanowski, John Q.
- Schneider, Julie A.
- Abisambra, Jose F.
- Abner, Erin L.
- Alafuzoff, Irina
- Arnold, Steven E.
- Attems, Johannes
- Beach, Thomas G.
- Bigio, Eileen H.
- Dickson, Dennis W.
- Gearing, Marla
- Grinberg, Lea T.
- Hof, Patrick R.
- Hyman, Bradley T.
- Jellinger, Kurt
- Jicha, Gregory A.
- Knopman, David S.
- Kofler, Julia
- Kukull, Walter A.
- Mackenzie, Ian R.
- Masliah, Eliezer
- McKee, Ann
- Montine, Thomas J.
- Murray, Melissa E.
- Neltner, Janna H.
- Seeley, William W.
- Shelanski, Michael L.
- Stein, Thor
- Takao, Masaki
- Thal, Dietmar R.
- Troncoso, Juan C.
- White, Charles L.
- Woltjer, Randall L.
- Yamada, Masahito
- Nelson, Peter T.
- Venue
- Acta Neuropathologica
- Published
- 2014-10-28
- Volume
- 128
- Issue
- 6
- Pages
- 755-766
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4257842
- OpenAlex
- W1971032265
- Cited by
- 1,467
- References
- 160
- Citations by year
- 2026: 85 · 2025: 126 · 2024: 154 · 2023: 123 · 2022: 154 · 2021: 142 · 2020: 143 · 2019: 131 · 2018: 107 · 2017: 119 · 2016: 105 · 2015: 68 · 2014: 9
- FWCI
- 66.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Alzheimer's Association (P30 AG013854, P30AG010124, P01 AG003991, P50 AG025688, P50 AG005681, NIRG-11-204450, P50 AG005136, P50 AG005146)
- BrightFocus Foundation (U01 AG006786, P50 AG016574, P50 AG005136)
- Mayo Foundation for Medical Education and Research (AG016574)
- Alzheimer Forschung Initiative (#13803)
- Alzheimer's Society (AS-PG-2013-011)
- National Institute for Health and Care Research
- Bundesministerium für Bildung und Forschung
- National Institutes of Health (AG028 383, 5r01ag038651-10, AG016574, AG010124, AG005138, AG005133, AG005131, AG008051, AG005681, AG019610, AG003991, AG013854, AG025688, AG003949, AG005136, AG011378)
- Medical Research Council (G0400074, U01 AG006786)
- Japan Society for the Promotion of Science (26430060)
- National Institute on Aging (AG008051, R01‐AG038651, R01AG037212, P30AG028383, P01AG007232, P30AG012300, R37AG018440, P50AG005133, AG184440, U01AG016976, P50AG005131, P50AG005138, U01AG006786, P01AG003949, P30AG010124, AG005131, R01AG011378, P30AG008051, P50AG008702, P50AG005681, P30AG036453, P30AG019610, P50AG005146, P01AG003991, P30AG013846, P50AG005136, P30AG013854, P50AG025688, R01AG041851, P01AG002219, P01AG019724, P50AG016574)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- primary age-related tauopathy, neurofibrillary tangles, tau pathology, Alzheimer's disease, nomenclature, temporal lobe atrophy, tau biomarkers, tau imaging, brain aging, cognitive impairment
- MeSH terms
- Aging, Brain, Diagnosis, Differential, Humans, Terminology as Topic, Tauopathies, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
