Host–pathogen interactions in bacterial meningitis.
Open accessAbstract
Bacterial meningitis is a devastating disease occurring worldwide with up to half of the survivors left with permanent neurological sequelae. Due to intrinsic properties of the meningeal pathogens and the host responses they induce, infection can cause relatively specific lesions and clinical syndromes that result from interference with the function of the affected nervous system tissue. Pathogenesis is based on complex host-pathogen interactions, some of which are specific for certain bacteria, whereas others are shared among different pathogens. In this review, we summarize the recent progress made in understanding the molecular and cellular events involved in these interactions. We focus on selected major pathogens, Streptococcus pneumonia, S. agalactiae (Group B Streptococcus), Neisseria meningitidis, and Escherichia coli K1, and also include a neglected zoonotic pathogen, Streptococcus suis. These neuroinvasive pathogens represent common themes of host-pathogen interactions, such as colonization and invasion of mucosal barriers, survival in the blood stream, entry into the central nervous system by translocation of the blood-brain and blood-cerebrospinal fluid barrier, and induction of meningeal inflammation, affecting pia mater, the arachnoid and subarachnoid spaces.
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CNS inflammation and disruption of the BBB results in CNS tissue damage through apoptotic neuronal injury, oedema, microvascular thrombosis and raised intracranial pressure.
“CNS inflammation and disruption of the BBB results in CNS tissue damage through apoptotic neuronal injury, oedema, microvascular thrombosis and raised intracranial pressure.26”
From Community-acquired acute bacterial meningitis in adults: a clinical update (2019) · cites this paper as [26]
In cases of bacterial meningitis, infections usually start as skin, gastrointestinal or respiratory infections that spread to the blood, and bacteria accumulate in the leptomeningeal vasculature and move into the meninges by inducing BBB breakdown.
“In cases of bacterial meningitis, infections usually start as skin, gastrointestinal or respiratory infections that spread to the blood”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Doran et al., 2016
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References 165 · Cited by 208
- Authors
- Doran, K. S., Fulde, M., Gratz, N., Kim, B. J., Nau, R., Prasadarao, N., Schubert-Unkmeir, A., Tuomanen, E. I., & Valentin-Weigand, P.
- Affiliations
- San Diego State University (US)
- University of Veterinary Medicine Hannover, Foundation (DE)
- St. Jude Children's Research Hospital (US)
- Universitätsmedizin Göttingen (DE)
- University of Southern California (US)
- Venue
- Acta Neuropathologica
- Published
- 2016-01-07
- Volume
- 131
- Issue
- 2
- Pages
- 185-209
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4713723
- OpenAlex
- W2228954012
- Cited by
- 208
- References
- 165
- Citations by year
- 2026: 23 · 2025: 22 · 2024: 25 · 2023: 20 · 2022: 19 · 2021: 22 · 2020: 22 · 2019: 21 · 2018: 18 · 2017: 10 · 2016: 6
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Acta Neuropathologica (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by)
- Funders
- Niedersachsen-Research Network on Neuroinfectiology (N-RENNT) of the Ministry of Science and Culture of Lower Saxony, Germany
- NIH/NINDS (RO1NS051247)
- National Institutes of Health (AI40567, NS73115, HD41525)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- bacterial meningitis, host-pathogen interaction, Streptococcus pneumoniae, Streptococcus agalactiae, Neisseria meningitidis, Escherichia coli K1, Streptococcus suis, meningeal inflammation, blood-brain barrier, blood-CSF barrier, translocation, mucosal colonization, pia mater, arachnoid, subarachnoid space, pathogenesis
- MeSH terms
- Animals, Brain, Humans, Meningitis, Bacterial, Host-Pathogen Interactions
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