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Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players
Open accessAbstract
In retired professional association football (soccer) players with a past history of repetitive head impacts, chronic traumatic encephalopathy (CTE) is a potential neurodegenerative cause of dementia and motor impairments. From 1980 to 2010, 14 retired footballers with dementia were followed up regularly until death. Their clinical data, playing career, and concussion history were prospectively collected. Next-of-kin provided consent for six to have post-mortem brain examination. Of the 14 male participants, 13 were professional and 1 was a committed amateur. All were skilled headers of the ball and had played football for an average of 26 years. Concussion rate was limited in six cases to one episode each during their careers. All cases developed progressive cognitive impairment with an average age at onset of 63.6 years and disease duration of 10 years. Neuropathological examination revealed septal abnormalities in all six post-mortem cases, supportive of a history of chronic repetitive head impacts. Four cases had pathologically confirmed CTE; concomitant pathologies included Alzheimer's disease (N = 6), TDP-43 (N = 6), cerebral amyloid angiopathy (N = 5), hippocampal sclerosis (N = 2), corticobasal degeneration (N = 1), dementia with Lewy bodies (N = 1), and vascular pathology (N = 1); and all would have contributed synergistically to the clinical manifestations. The pathological diagnosis of CTE was established in four individuals according to the latest consensus diagnostic criteria. This finding is probably related to their past prolonged exposure to repetitive head impacts from head-to-player collisions and heading the ball thousands of time throughout their careers. Alzheimer's disease and TDP-43 pathologies are common concomitant findings in CTE, both of which are increasingly considered as part of the CTE pathological entity in older individuals. Association football is the most popular sport in the world and the potential link between repetitive head impacts from playing football and CTE as indicated from our findings is of considerable public health interest. Clearly, a definitive link cannot be established in this clinico-pathological series, but our findings support the need for further systematic investigation, including large-scale case-control studies to identify at risk groups of footballers which will justify for the implementation of protective strategies.
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“It is now well established that a large percentage of former athletes identified as having CTE neuropathology also have neuropathology associated with age related neurodegenerative diseases such as AD, PD, Lewy body disease, hippocampal sclerosis, and ALS [14, 41–44] to the extent that they meet full neuropathological criteria for an alternative, well-characterized neurodegenerative disease [16].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [44]
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Metadata
- Authors
- Ling, H., Morris, H. R., Neal, J. W., Lees, A. J., Hardy, J., Holton, J. L., Revesz, T., & Williams, D. D. R.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- UCL Queen Square Institute of Neurology (GB)
- Cardiff University (GB)
- Cefn Coed Hospital (GB)
- Corresponding author
- Holton, Janice L.
- Venue
- Acta Neuropathologica
- Published
- 2017-02-15
- Volume
- 133
- Issue
- 3
- Pages
- 337-352
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC5325836
- OpenAlex
- W2588072485
- Cited by
- 252
- References
- 45
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 20 · 2023: 31 · 2022: 28 · 2021: 30 · 2020: 51 · 2019: 28 · 2018: 16 · 2017: 16
- FWCI
- 23.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Acta Neuropathologica (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- The Drake Foundation
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- chronic traumatic encephalopathy, soccer, dementia, repetitive head impacts, Alzheimer's disease, TDP-43, cerebral amyloid angiopathy, hippocampal sclerosis, corticobasal degeneration, dementia with Lewy bodies, neuropathology, concussion
- MeSH terms
- Chronic Traumatic Encephalopathy, Sequestosome-1 Protein, Aged, Aged, 80 and over, Autopsy, Brain, Calcium-Binding Proteins, Dementia, DNA-Binding Proteins, Humans, Male, Microfilament Proteins, Middle Aged, Retirement, Retrospective Studies, Soccer, Amyloid beta-Peptides, tau Proteins, alpha-Synuclein
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