The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Histochemical and morphometrical analysis of skeletal muscle in spontaneous diabetic WBN/Kob rat
Abstract
Spontaneous diabetic WBN/Kob rats develop diabetic peripheral neuropathy characterized by primary segmental demyelination and secondary axonal degeneration. The objective of this study was to evaluate the histochemical and morphometric characteristics of the lesions of skeletal muscles innervated by the affected nerves in diabetic rats. The following groups of rats were investigated: 24-month-old males that had been diabetic for less than 12 months, 10-month-old pre-diabetic males, 24-month-old non-diabetic females, and 10-month-old nondiabetic females. The soleus (SOL), extensor digitorum longus (EDL) and biceps femoris (BF) muscles were studied by light and electron microscopy, including histochemical and morphometric analyses. Muscle weight was reduced with age to a remarkable degree in diabetic BF and EDL. Dispersed atrophy of muscle fiber was observed in type 2a fibers of BF and EDL, and type 2c fibers of SOL, and the incidence was higher in diabetic rats. Multi-core, myofibrillar disorientation and an increased number of central nucleus of SOL, along with connective tissue proliferation of BF perimysium were noted in diabetic rats. The fiber population and type of composition varied with age, but no remarkable changes attributable to diabetic conditions were observed. Electron microscopically, an abnormal arrangement of myofibrils, a number of myelin figures, mitochondrial swelling and lysis of mitochondrial cristae were seen in diabetic rats. However, the neuromuscular…
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“In addition, skeletal muscle from WBN/Kob diabetic rats show mitochondrial swelling and lysis of mitochondrial cristae (22)”
From Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle (2005) · cites this paper as [22]
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Metadata
- Authors
- Ozaki, K., Matsuura, T., & Narama, I.
- Affiliations
- Setsunan University (JP)
- Corresponding author
- Ozaki, Kiyokazu
- Venue
- Acta Neuropathologica
- Published
- 2001-09
- Volume
- 102
- Issue
- 3
- Pages
- 264-270
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W76739859
- Cited by
- 17
- References
- 21
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- diabetic peripheral neuropathy, skeletal muscle, WBN/Kob rat, muscle fiber atrophy, myofibrillar disorganization, muscle fiber composition, myelin figures, mitochondrial swelling, soleus muscle, extensor digitorum longus, biceps femoris
- MeSH terms
- Aging, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Diabetic Neuropathies, Disease Models, Animal, Female, Glycosuria, Male, Rats, Inbred Strains, Muscle, Skeletal, Muscle Development, Diabetes Complications, Rats
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