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Cited by 103Nail Diseases and TreatmentsDermatology and Skin DiseasesAdvancements in Transdermal Drug Delivery

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Dandruff: a condition characterized by decreased levels of intercellular lipids in scalp stratum corneum and impaired barrier function

Harding, C. R., Moore, A. E., Rogers, S. J., Meldrum, H., Scott, A. E., McGlone, F. P.·2002·Archives of Dermatological Research
DOI 10.1007/s00403-002-0323-1
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Abstract

Dandruff is a major problem, yet little is known about the underlying mechanism and subsequent biochemical changes occurring in the scalp skin that lead to its manifestation. The characteristic flaking and scaling of the scalp experienced by dandruff sufferers suggests, similar to the changes classically seen in xerosis, that the desquamation process is impaired. We initiated studies to quantify the biochemical nature of the stratum corneum in the scalp of healthy individuals and dandruff sufferers. Total amounts and relative ratios of stratum corneum lipids species were analysed in scalp stratum corneum samples collected during studies conducted in the UK and Thailand in order to examine ethnic differences. In both populations, dandruff was associated with a dramatic decrease in free lipid levels, with significant decreases in ceramides, fatty acids, and cholesterol. Detailed sub-analysis of the major ceramide species within the total ceramide fraction revealed a decrease in ceramide 1 and increased proportions of ceramide 6i and 6ii. In a separate study, we demonstrated that dandruff sufferers show both an elevated blood flow and an increased reported incidence of itch in response to histamine topically applied to the scalp compared with no-dandruff controls. Taken together these two studies indicate that the quality and resilience of the epidermal water barrier is impaired in the scalp of dandruff sufferers. We propose that the perturbed barrier leaves dandruff sufferers more prone to the adverse effects of microbial and fungal toxins, and environmental pollutants, thus perpetuating their impaired barrier.

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Metadata

Authors
Harding, C. R., Moore, A. E., Rogers, S. J., Meldrum, H., Scott, A. E., & McGlone, F. P.
Affiliations
Unilever (United Kingdom) (GB)
Corresponding author
Harding, C. R.
ORCID
McGlone, F. P.
Venue
Archives of Dermatological Research
Publisher
Springer Science and Business Media LLC
Published
2002-06-07
Volume
294
Issue
5
Pages
221-230
ISSN
  • 0003-9187 (ISSN-L)
  • 0340-3696
  • 1432-069X
DOI
10.1007/s00403-002-0323-1
OpenAlex
W2165529368
Cited by
103
References
34
Citations by year
2026: 6 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 3 · 2018: 3 · 2017: 10 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 7
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Archives of Dermatological Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Nail Diseases and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
dandruff, intercellular lipids, ceramide, free lipids, cholesterol, fatty acids, skin barrier function, desquamation, ethnic differences, histamine-induced itch, blood flow, scalp skin
MeSH terms
Administration, Cutaneous, Adult, Cholesterol, Epidermis, Ethnicity, Fatty Acids, Fatty Acids, Nonesterified, Female, United Kingdom, Histamine, Humans, Male, Permeability, Pruritus, Scalp, Scalp Dermatoses, Dermatitis, Seborrheic, Thailand, Case-Control Studies, Lipid Metabolism

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