Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: A meta-analysis
Abstract
Purpose The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer).Methods We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle-Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR).Results Of the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case-control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)].Conclusions Patients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes.
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Angiogenesis promoted by VEGF can establish a local vascular network within endometriotic lesions.
“An additional important role is played by the angiogenesis promoted by the vascular endothelial growth factor (VEGF) which can establish a local vascular network within endometriotic lesions.”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [49]
The high iron content present in endometriotic lesions may contribute to excessive oxidative stress, which may favor the induction of mutations.
“The high iron content present in endometriotic lesions may also contribute to this excessive oxidative stress, which may favor the inductions of mutations [45,49].”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [49]
The hypoxic microenvironment of endometriosis causes excessive oxidative stress.
“This effect is promoted by the hypoxic microenvironment of endometriosis, which is known to cause excessive oxidative stress.”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [49]
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References 62 · Cited by 56
- Authors
- li, J., Liu, R., Tang, S., Feng, F., Liu, C., Wang, L., Zhao, W., Zhang, T., Yao, Y., Wang, X., & Sun, C.
- Affiliations
- Weifang Medical University (CN)
- Weifang Chinese Medicine Hospital (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Qingdao University (CN)
- Corresponding author
- Sun, Changgang
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2018-11-20
- Volume
- 299
- Issue
- 1
- Pages
- 35-46
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2901646825
- Cited by
- 56
- References
- 62
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 3
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- endometriosis, ovarian cancer, endometrial cancer, cervical cancer, gynecologic cancer risk, cancer risk association
- MeSH terms
- Uterine Cervical Neoplasms, Endometriosis, Endometrium, Female, Genital Neoplasms, Female, Humans, Ovarian Neoplasms, Risk, Cohort Studies, Odds Ratio, Case-Control Studies, Endometrial Neoplasms
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