Validation of the investigator argus y-28 qs kit on the seqstudio™ genetic analyzer for hid: A new panel file for genemapper id-x software v1.6
Abstract
Background The Investigator Argus Y-28 QS Kit is a 27-locus, six-dye multiplex, which includes six rapidly mutating Short Tandem Repeats (RM Y-STRs). Methods A new text file containing the optimized panel and bin sets for GeneMapper ID-X Software v1.6 has been prepared. In addition, an internal validation study was conducted on the Investigator Argus Y-28 QS kit using the SeqStudio™ Genetic Analyzer for HID. Results The full results of that study are presented here, including data on precision, sensitivity, reproducibility, stutter determination, and reduction volume analysis. A concordance study and three case reports are documented. Finally, the kit was successfully used to conduct a proficiency test. Conclusions The obtained findings achieved a satisfactory performance of the Investigator Argus Y-28 QS Kit on the SeqStudio™ Genetic Analyzer for HID.
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Software solutions like GeneMapper ID-X, STRait Razor, and HipSTR include peak-height ratios, heterozygosity thresholds, and ladder alignment checks to minimize false calls.
“While software solutions like GeneMapper® ID-X [41], STRait Razor [42], and the open-source Haplotype inference and phasing for STRs (HipSTR) [43] include peak-height ratios, heterozygosity thresholds, and ladder alignment checks to minimize false calls, expert review remains crucial [44].”
From Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review (2026) · cites this paper as [41]
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Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review
Weiskirchen, R. (2026) · Medical Sciences · doi:10.3390/medsci14010025 · Cited by 4 · see citing works
- Authors
- Soldati, G., Turrina, S., & Ausania, F.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Soldati, Giulia
- Venue
- International Journal of Legal Medicine
- Published
- 2025-06-20
- Volume
- 139
- Issue
- 6
- Pages
- 2635-2645
- ISSN
- 0044-3433 (ISSN-L)
- 0937-9827
- 1437-1596
- OpenAlex
- W4411441367
- Cited by
- 1
- References
- 0
- Citations by year
- 2026: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Legal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Molecular Biology Techniques and Applications
- Keywords
- Y-STR profiling, rapidly mutating Y-STRs, kit validation, proficiency testing, forensic DNA analysis
- MeSH terms
- Humans, Male, Software, Reproducibility of Results, DNA Fingerprinting, Microsatellite Repeats, Chromosomes, Human, Y
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