The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Patients with migraine do not have MRI-visible cortical lesions
Abstract
Migraine patients with multiple brain white matter hyperintensities (WMHs) may represent a diagnostic challenge. Using double inversion recovery (DIR) imaging, we studied whether cortical lesions (CLs) could be seen in these patients. Approval of the institutional review boards and written informed consent were obtained from each participant. CLs and WM lesions were assessed on brain scans from 32 migraine patients with WMHs (17 patients with and 15 without aura), and in two control groups, consisting of 15 relapsing-remitting multiple sclerosis (RRMS) patients and 20 healthy controls, matched for age and gender. By definition, brain WM lesions were detected in all migraine and RRMS patients. The number and volume of WM lesions were lower in migraine versus RRMS patients (p < 0.0001). No CLs were identified in migraine patients and healthy controls, whereas 20 CLs were seen in 9 (60 %) RRMS patients. The application of DIR imaging to assess focal cortical involvement seems to be useful in the diagnostic workup of patients with WMHs of unknown etiology, including those with migraine.
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MRI in patients with small-vessel cerebrovascular disease, other inflammatory and noninflammatory disorders affecting white matter, and even in healthy subjects (especially in older age groups), may show brain lesions that fulfil MRI criteria for MS.
“MRI in patients with small-vessel cerebrovascular disease, other inflammatory and noninflammatory disorders affecting white matter (see examples in Tables 2 & 3), and even in healthy subjects (especially in older age groups), may show brain lesions that fulfil MRI criteria for MS [21][22][23][24]”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [24]
The typical demyelinating lesions that characterise RIS need to be carefully differentiated from small-vessel cerebrovascular disease and nonspecific white matter lesions (the latter being common in people with migraine).
“The typical demyelinating lesions that characterise RIS need to be carefully differentiated from small-vessel cerebrovascular disease and nonspecific white matter lesions (the latter being common in people with migraine 21,24 ).”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [24]
Cortical grey matter lesions have not been found in migraine.
“or migraine.24”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [24]
Citations
Cites
Cortical lesions in multiple sclerosis
Calabrese, M., Filippi, M., & Gallo, P. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.93 · Cited by 269
Self-citationIntracortical lesions: Relevance for new MRI diagnostic criteria for multiple sclerosis
Filippi, M., Rocca, M. A., Calabrese, M., Sormani, M. P., Rinaldi, F., Perini, P., Comi, G., & Gallo, P. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ff96f6 · Cited by 172
Self-citationCortical lesions in radiologically isolated syndrome
Giorgio, A., Stromillo, M. L., Rossi, F., Battaglini, M., Hakiki, B., Portaccio, E., Federico, A., Amato, M. P., & De Stefano, N. (2011) · Neurology · doi:10.1212/wnl.0b013e318238ee9b · Cited by 77
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Research works printed but not linked: 14
- Charil A, Yousry TA, Rovaris M, Barkhof F, De Stefano N, Fazekas F, Miller DH, Montalban X, Simon JH, Polman C, Filippi M (2006) MRI and the diagnosis of multiple sclerosis: expanding the concept of “no better explanation”. Lancet Neurol 5:841–852 · DOI
- Cotton F, Rambaud L, Hermier M (2006) Dual inversion recovery MRI helps identifying cortical tubers in tuberous sclerosis. Epilepsia 47:1072–1073 · DOI
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Cited by
Sorted by citations
Diagnosis of multiple sclerosis: progress and challenges
Brownlee, W. J., Hardy, T. A., Fazekas, F., & Miller, D. H. (2017) · The Lancet · doi:10.1016/s0140-6736(16)30959-x · Cited by 701
Metadata
- Authors
- Absinta, M., Rocca, M. A., Colombo, B., Copetti, M., Feo, D., Falini, A., Comi, G., & Filippi, M.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Casa Sollievo della Sofferenza (IT)
- Corresponding author
- Filippi, Massimo
- ORCID
- Venue
- Journal of Neurology
- Published
- 2012-06-20
- Volume
- 259
- Issue
- 12
- Pages
- 2695-2698
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2089069160
- Cited by
- 66
- References
- 3
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Keywords
- migraine, white matter hyperintensities, cortical lesions, relapsing-remitting multiple sclerosis, migraine with aura, brain MRI
- MeSH terms
- Adult, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Migraine Disorders, Young Adult
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