The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Vaccines and multiple sclerosis: a systematic review
Abstract
Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles-mumps-rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.
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“Two recent systematic reviews looking at the association between different individual vaccines and central demyelinating disorders (hepatitis B, human papilloma virus (HPV), influenza, MMR, varicella, tetanus, Bacillus Calmette Guérin (BCG), polio or diphtheria) concluded that there was no relationship between receipt of a vaccine and development of MS (Mailand and Frederiksen, 2017; Mouchet et al”
From Vaccine Safety: Myths and Misinformation (2020) · cites this paper as Mailand and Frederiksen, 2017
In the citing paper
“Existing epidemiologic studies have found no associations between the number of different vaccines and an increased risk of autoimmune disorders.”
From Vaccine Safety: Myths and Misinformation (2020) · cites this paper as Mailand and Frederiksen, 2017
Citations
Cites
Vaccinations and the Risk of Relapse in Multiple Sclerosis
Confavreux, C., Suissa, S., Saddier, P., Bourdès, V., & Vukusic, S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440501 · Cited by 490
Hepatitis B Vaccination and the Risk of Multiple Sclerosis
Ascherio, A., Zhang, S. M., Hernán, M. Á., Olek, M. J., COPLAN, P. M., Brodovicz, K. G., & Walker, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440502 · Cited by 433
Recombinant hepatitis B vaccine and the risk of multiple sclerosis
Hernán, M. Á., Jick, S. S., Olek, M. J., & Jick, H. (2004) · Neurology · doi:10.1212/01.wnl.0000138433.61870.82 · Cited by 302
Vaccinations and Risk of Central Nervous System Demyelinating Diseases in Adults
Destefano, F. R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.4.504 · Cited by 256
Chao, C., Klein, N. P., Velicer, C. M., Sy, L. S., Slezak, J. M., Takhar, H. S., Ackerson, B. K., Cheetham, T. C., Hansen, J. R., Deosaransingh, K. A., et al. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02467.x · Cited by 204
Vaccines and the Risk of Multiple Sclerosis and Other Central Nervous System Demyelinating Diseases
Langer-Gould, A. M., Qian, L., Tartof, S. Y., Brara, S. M., Jacobsen, S. J., Beaber, B., Sy, L. S., Chao, C., Hechter, R. C., & Tseng, H. F. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2633 · Cited by 190
Bardage, C., Persson, I., Örtqvist, Å., Bergman, U., Ludvigsson, J. F., & Granath, F. (2011) · BMJ · doi:10.1136/bmj.d5956 · Cited by 190
Scheller, N. M., Svanström, H., Pasternak, B., Arnheim‐Dahlström, L., Sundström, K., Fink, K., & Hviid, A. P. (2015) · JAMA · doi:10.1001/jama.2014.16946 · Cited by 182
Use of Bacille Calmette–Guerin (BCG) in multiple sclerosis
Ristori, G., Buzzi, M. G., Sabatini, U., Giugni, E., Bastianello, S., Viselli, F., Buttinelli, C., Ruggieri, S. A., Colonnese, C., Pozzilli, C., et al. (1999) · Neurology · doi:10.1212/wnl.53.7.1588 · Cited by 158
No increase in demyelinating diseases after hepatitis B vaccination
Zipp, F., Weil, J., & Einhäupl, K. M. (1999) · Nature Medicine · doi:10.1038/12376 · Cited by 156
Cited by
Sorted by citations
Vaccine Safety: Myths and Misinformation
Geoghegan, S., O’Callaghan, K. P., & Offit, P. A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00372 · Cited by 275
“A metanalysis of 39 controlled observational studies found that the relative risk of GBS following receipt of any influenza vaccine was 1.41 (Martin Arias et al., 2015).”
InfluentialCOVID-19 vaccination in patients with multiple sclerosis: What we have learnt by February 2021
Achiron, A., Dolev, M., Menascu, S., Zohar, D. N., Dreyer-Alster, S., Miron, S., Shirbint, E., Magalashvili, D., Flechter, S., Givon, U., et al. (2021) · Multiple Sclerosis Journal · doi:10.1177/13524585211003476 · Cited by 212
Ocular Adverse Events After COVID-19 Vaccination
Ng, X. L., Betzler, B. K., Testi, I., Ho, S. L., Tien, M. C.-H., Ngo, W. K., Zierhut, M., Chee, S.-P., Gupta, V., Pavesio, C. E., et al. (2021) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2021.1976221 · Cited by 187
Wagner, N., Assmus, F., Arendt, G., Baum, E., Baumann, U., Bogdan, C., Burchard, G. D., Föll, D., Garbe, E., Hecht, J., et al. (2019) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-019-02905-1 · Cited by 150
Effects of MS disease-modifying therapies on responses to vaccinations: A review.
Ciotti, J. R., Valtcheva, M. V., & Cross, A. H. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102439 · Cited by 135
Metadata
- Authors
- Mailand, M. T., & Frederiksen, J. L.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Frederiksen, Jette Lautrup
- Venue
- Journal of Neurology
- Published
- 2016-09-07
- Volume
- 264
- Issue
- 6
- Pages
- 1035-1050
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2514636267
- Cited by
- 154
- References
- 63
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 14 · 2023: 23 · 2022: 20 · 2021: 32 · 2020: 22 · 2019: 12 · 2018: 14 · 2017: 6 · 2016: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- multiple sclerosis, vaccines, hepatitis B vaccine, HPV vaccine, seasonal influenza vaccine, MMR vaccine, smallpox vaccine, tetanus vaccine, BCG vaccine, diphtheria vaccine, polio vaccine, multiple sclerosis risk, relapse
- MeSH terms
- Animals, Humans, Multiple Sclerosis, Vaccination
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