PET-measurable innate immune cell activation reduction in chronic active lesions in PPMS brain after rituximab treatment: A case report

Lehto, Jussi; Sucksdorff, Marcus; Nylund, Marjo; Raitanen, Roope; Matilainen, Markus; Airas, Laura

doi:10.1007/s00415-022-11539-4

PET-measurable innate immune cell activation reduction in chronic active lesions in PPMS brain after rituximab treatment: A case report

Objectives To evaluate the effects of rituximab treatment on innate immune cell activation in primary progressive multiple sclerosis (PPMS). Methods A 48-year-old woman with PPMS was started on rituximab shortly after diagnosis. [ 11 C]PK11195 PET imaging was employed to assess innate immune cell…