Neurological complications of radiotherapy and chemotherapy
Abstract
Neurological complications of radiotherapy and chemotherapy can affect the central or peripheral nervous system. Most are dose-dependent and constitute a limiting factor in the administration of treatments. Radiation-induced neurological complications are classified as acute, early-delayed or delayed. The most important are radionecrosis and cognitive dysfunction/leukoencephalopathy. Neurotoxicity of chemotherapy is frequent and depends upon dose, type of drugs (especially cisplatin and methotrexate) and their combination with radiotherapy.
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Ionizing radiation can damage the CNS, causing changes to cognitive function, inducing fatigue, and generating performance decrements.
“Ionizing radiation can damage the CNS, causing changes to cognitive function, inducing fatigue, and generating performance decrements [2,30,42,43,44,45,46,47,48,49,50,51].”
From Space Radiation: The number one risk to astronaut health beyond low earth orbit (2014) · cites this paper as [45]
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References 65 · Cited by 246
- Authors
- Keime-Guibert, F., Napolitano, M., & Delattre, J.-Y.
- Affiliations
- Pitié-Salpêtrière Hospital (FR)
- ORCID
- Napolitano, Massimo
- Venue
- Journal of Neurology
- Published
- 1998-10-01
- Volume
- 245
- Issue
- 11
- Pages
- 695-708
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2053825022
- Cited by
- 246
- References
- 65
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 9 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 11
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Brain Metastases and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- chemotherapy-induced neurotoxicity, radiation necrosis, cognitive impairment, leukoencephalopathy, cisplatin neurotoxicity, methotrexate neurotoxicity, dose-dependent toxicity, central nervous system toxicity, peripheral nervous system toxicity
- MeSH terms
- Antineoplastic Agents, Cognition, Dose-Response Relationship, Drug, Humans, Neoplasms, Nervous System Diseases, Radiotherapy, Spinal Cord, Cranial Irradiation
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