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Cited by 3Retinal Development and DisordersOrgan and Tissue Transplantation ResearchXenotransplantation and immune response

The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.

Immune privilege of allogeneic neuroretinal transplants in the subconjunctival space

Ghosh, Fredrik, Rauer, Ola, Arnér, Karin·2008·Graefe's Archive for Clinical and Experimental Ophthalmology
DOI 10.1007/s00417-008-0933-1
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Abstract

Background The extent of site and tissue-associated immune privilege is of great interest in transplantation experiments involving the CNS. In the present paper we have explored neuroretinal immune privilege by transplantation to a non-immune privileged site.Methods Fetal and adult full-thickness rabbit neuroretinal grafts were placed in the subconjunctival space of immunocompetent rabbit hosts. Morphological examination was performed after 2-31 days (fetal grafts, n = 46), and after 8 days (adult grafts, n = 4).Results Hematoxylin and eosin-stained sections and immunohistochemistry directed against microtubule-associated protein 2 (MAP2) revealed surviving grafts containing retinal neurons in the majority of eyes with fetal grafts. In all specimens, a mild inflammatory reaction was evident as seen with major histocompatibility complex class II (MHC-II) labeling. Short-term grafts survived well and displayed lamination and rosette formation whereas older grafts appeared more disorganized and were more often rejected. Müller cell fibers labeled with glial fibrillary acidic protein (GFAP) were present in grafts from 15 days and onwards. Adult grafts were destroyed after 8 days.Conclusions Allogeneic fetal full-thickness neuroretinal transplants can survive for several weeks in a non-immune privileged environment in which adult grafts are rapidly rejected. Fetal grafts gradually shrink, lose their architecture and go through a glial transformation accompanied by low-grade inflammation. The rabbit neuroretina thus appears to enjoy partial immune privilege, the extent of which depends on the development state of the tissue. The characterization of neuroretinal immune privilege will hopefully influence future clinical trials of retinal transplantation.

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Crossref · 10.1007/s00417-008-0933-1

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Metadata

Authors
Ghosh, F., Rauer, O., & Arnér, K.
Affiliations
Skåne University Hospital (SE)
Corresponding author
Ghosh, Fredrik
ORCID
Ghosh, Fredrik
Venue
Graefe's Archive for Clinical and Experimental Ophthalmology
Publisher
Springer Science and Business Media LLC
Published
2008-08-27
Volume
246
Issue
12
Pages
1715-1722
ISSN
  • 0721-832X (ISSN-L)
  • 1435-702X
DOI
10.1007/s00417-008-0933-1
OpenAlex
W2089914919
Cited by
3
References
30
Citations by year
2022: 1 · 2019: 1 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Graefe s Archive for Clinical and Experimental Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
  • Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
  • Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
Keywords
immune privilege, allogeneic transplantation, graft survival, graft rejection, Müller cells, MAP2, retinal transplantation, rabbits
MeSH terms
Animals, Conjunctiva, Embryo, Mammalian, Genes, MHC Class II, Glial Fibrillary Acidic Protein, Graft Rejection, Graft Survival, Immune Tolerance, Inflammation, Microtubule-Associated Proteins, Neurons, Rabbits, Retina, Rosette Formation, Ophthalmologic Surgical Procedures, Time Factors, Transplantation Immunology, Transplantation, Homologous, Fetal Tissue Transplantation

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