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Cited by 658Spaceflight effects on biologyCardiovascular Syncope and Autonomic DisordersSpace Exploration and Technology

The DOI matches its Crossref record; 486 of the 486 references it cites were found in a registry or an index.

From space to Earth: advances in human physiology from 20 years of bed rest studies (1986–2006)

Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., Vernikos, J.·2007·European Journal of Applied Physiology
DOI 10.1007/s00421-007-0474-z
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Abstract

Bed rest studies of the past 20 years are reviewed. Head-down bed rest (HDBR) has proved its usefulness as a reliable simulation model for the most physiological effects of spaceflight. As well as continuing to search for better understanding of the physiological changes induced, these studies focused mostly on identifying effective countermeasures with encouraging but limited success. HDBR is characterised by immobilization, inactivity, confinement and elimination of Gz gravitational stimuli, such as posture change and direction, which affect body sensors and responses. These induce upward fluid shift, unloading the body's upright weight, absence of work against gravity, reduced energy requirements and reduction in overall sensory stimulation. The upward fluid shift by acting on central volume receptors induces a 10-15% reduction in plasma volume which leads to a now well-documented set of cardiovascular changes including changes in cardiac performance and baroreflex sensitivity that are identical to those in space. Calcium excretion is increased from the beginning of bed rest leading to a sustained negative calcium balance. Calcium absorption is reduced. Body weight, muscle mass, muscle strength is reduced, as is the resistance of muscle to insulin. Bone density, stiffness of bones of the lower limbs and spinal cord and bone architecture are altered. Circadian rhythms may shift and are dampened. Ways to improve the process of evaluating countermeasures--exercise (aerobic, resistive, vibration), nutritional and pharmacological--are proposed. Artificial gravity requires systematic evaluation. This review points to clinical applications of BR research revealing the crucial role of gravity to health.

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Citations

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Items 401–486 of 486

Research works printed but not linked: 15

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Metadata

Authors
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J.
Affiliations
  • Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
  • Manchester Metropolitan University (GB)
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2007-07-28
Volume
101
Issue
2
Pages
143-194
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-007-0474-z
OpenAlex
W1978795695
Cited by
658
References
486
Citations by year
2026: 34 · 2025: 40 · 2024: 34 · 2023: 44 · 2022: 32 · 2021: 57 · 2020: 55 · 2019: 32 · 2018: 36 · 2017: 47 · 2016: 46 · 2015: 23 · 2014: 37 · 2013: 29 · 2012: 19
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • e-space (Manchester Metropolitan University) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Physical Sciences › Engineering › Aerospace Engineering › Space Exploration and Technology
Keywords
head-down bed rest, simulated microgravity, spaceflight countermeasures, fluid shifts, plasma volume, baroreflex sensitivity, cardiac function, calcium balance, muscle atrophy, bone loss, circadian rhythm, exercise countermeasures, vibration training, artificial gravity
MeSH terms
Bed Rest, Calcium, Cardiovascular Physiological Phenomena, Circadian Rhythm, Humans, Physiological Phenomena, Fluid Shifts, Space Simulation

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