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Cited by 238Sepsis Diagnosis and TreatmentAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and Efficacy

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Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study

Schroeder, S., Hochreiter, M., Koehler, T., Schweiger, A.-M., Bein, B., Keck, F. S., von Spiegel, T.·2009·Langenbeck's Archives of Surgery
DOI 10.1007/s00423-008-0432-1
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Abstract

Background Adequate indication and duration of administration are central issues of modern antibiotic treatment in intensive care medicine. The biochemical variable procalcitonin (PCT) is known to indicate systemically relevant bacterial infections with high accuracy. In the present study, we aimed to investigate the clinical usefulness of PCT for guiding antibiotic treatment in surgical intensive care patients with severe sepsis. Patients and methods Patients were randomly assigned to a PCT-guided or a control group requiring antibiotic treatment. All patients received a calculated antibiotic regimen according to the presumed microbiological spectrum. In the PCT-guided group, antibiotic treatment was discontinued if clinical signs of infection improved and the PCT value was either Results The PCT-guided group (n = 14 patients) and the control group (n = 13 patients) did not differ in terms of biological variables, underlying diseases, and overall disease severity. PCT guidance led to a significant reduction of antibiotic treatment from 6.6 +/- 1.1 days (mean +/- SD) compared with 8.3 +/- 0.7 days in control patients (p Conclusions Monitoring of PCT is a helpful tool for guiding antibiotic treatment in surgical intensive care patients with severe sepsis. This may contribute to an optimized antibiotic regimen with beneficial effects on microbial resistances and costs in intensive care medicine.

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Citations

Cites

Research works printed but not linked: 23

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Metadata

Authors
Schroeder, S., Hochreiter, M., Koehler, T., Schweiger, A.-M., Bein, B., Keck, F. S., & von Spiegel, T.
Affiliations
  • Westküstenkliniken Brunsbüttel und Heide gGmbH (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
ORCID
Venue
Langenbeck's Archives of Surgery
Publisher
Springer Science and Business Media LLC
Published
2008-11-26
Volume
394
Issue
2
Pages
221-226
ISSN
  • 0023-8236 (ISSN-L)
  • 1435-2443
  • 1435-2451
DOI
10.1007/s00423-008-0432-1
OpenAlex
W2052809746
Cited by
238
References
3
Citations by year
2026: 4 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 19 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 23 · 2016: 18 · 2015: 15 · 2014: 13 · 2013: 19 · 2012: 15
FWCI
6.31
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Langenbeck s Archives of Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
Keywords
procalcitonin, antibiotic stewardship, antibiotic duration, severe sepsis, surgical intensive care unit, sepsis monitoring, antibiotic treatment costs, empirical antibiotic therapy, antimicrobial resistance
MeSH terms
Aged, Aged, 80 and over, Algorithms, Anti-Bacterial Agents, C-Reactive Protein, Calcitonin, Critical Care, Drug Administration Schedule, Female, Humans, Length of Stay, Male, Middle Aged, Postoperative Complications, Predictive Value of Tests, Prospective Studies, Protein Precursors, Calcitonin Gene-Related Peptide, Hospital Mortality, Sepsis

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