Comparison of a lightweight polypropylene mesh (Optilene® LP) and a large-pore knitted PTFE mesh (GORE® INFINIT® mesh)—Biocompatibility in a standardized endoscopic extraperitoneal hernia model
Abstract
Purpose The use of a mesh with good biocompatibility properties is of decisive importance for the avoidance of recurrences and chronic pain in endoscopic hernia repair surgery. As we know from numerous experiments and clinical experience, large-pore, lightweight polypropylene meshes possess the best biocompatibility. However, large-pore meshes of different polymers may be used as well and might be an alternative solution. Methods Utilizing a totally extraperitoneal technique in an established animal model, 20 domestic pigs were implanted with either a lightweight large-pore polypropylene (PP) mesh (Optilene® LP) or a medium-weight large-pore knitted polytetrafluorethylene (PTFE) mesh (GORE® INFINIT® mesh). After 94 days, the pigs were sacrificed and postmortem diagnostic laparoscopy was performed, followed by explantation of the specimens for macroscopic, histological and immunohistochemical evaluation. Results The mean mesh shrinkage rate was 14.2% for Optilene® LP vs. 24.7% for INFINIT® mesh (p = 0.017). The partial volume of the inflammatory cells was 11.2% for Optilene® LP vs. 13.9% for INFINIT (n.s.). CD68 was significantly higher for INFINIT (11.8% vs. 5.6%, p = 0.007). The markers of cell turnover, namely Ki67 and the apoptotic index, were comparable at 6.4% vs. 12.4% (n.s.) and 1.6% vs. 2.0% (n.s.). In the extracellular matrix, TGF-β was 35.4% for Optilene® LP and 31.0% for INFINIT® (n.s.). Collagen I (pos/300 μm) deposits were 117.8 and 114.9, respectively. Conclusio…
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Lightweight and large-pore PP meshes have been developed to reduce the amount of implanted material, thus lowering the inflammatory response and improving patient outcomes.
“To address these issues, lightweight and large-pore PP meshes have been developed to reduce the overall amount of implanted material, thus lowering the inflammatory response and improving patient outcomes [247].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [247]
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Laparoscopic techniques versus open techniques for inguinal hernia repair
McCormack, K., Scott, N., Go, P. M. N. Y. H., Ross, S. J., Grant, A., & Collaboration the EU Hernia Trialists (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001785 · Cited by 809 · see citing works
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Jacob, D. A., Schug-Paß, C., Sommerer, F., Tannapfel, A., Lippert, H., & Köckerling, F.
- Affiliations
- Vivantes Klinikum (DE)
- Ruhr University Bochum (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Corresponding author
- Jacob, Dietmar A.
- Venue
- Langenbeck's Archives of Surgery
- Published
- 2011-10-12
- Volume
- 397
- Issue
- 2
- Pages
- 283-289
- ISSN
- 0023-8236 (ISSN-L)
- 1435-2443
- 1435-2451
- OpenAlex
- W2032081917
- Cited by
- 22
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Langenbeck s Archives of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Keywords
- biocompatibility, endoscopic hernia repair, totally extraperitoneal repair, polypropylene mesh, PTFE mesh, mesh shrinkage, chronic inflammation, CD68, TGF-beta, collagen deposition, extracellular matrix, porcine model, abdominal wall hernia, recurrence prevention, immunohistochemistry
- MeSH terms
- Analysis of Variance, Animals, Biocompatible Materials, Biopsy, Needle, Disease Models, Animal, Hernia, Inguinal, Immunohistochemistry, Materials Testing, Laparoscopy, Polypropylenes, Polytetrafluoroethylene, Random Allocation, Sensitivity and Specificity, Surgical Mesh, Swine, Wound Healing, Risk Assessment, Sus scrofa, Abdominal Wall, Herniorrhaphy
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