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Cited by 4Inflammatory Biomarkers in Disease PrognosisHepatocellular Carcinoma Treatment and PrognosisSepsis Diagnosis and Treatment

Interleukin-8 is superior to CRP for the prediction of severe complications in a prospective cohort of patients undergoing major liver resection

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Pecqueux, Mathieu, Brückner, Frederik, Bogner, Andreas, Oehme, Florian, Hau, Hans‑Michael, von Bechtolsheim, Felix, Held, Hanns‑Christoph, Baenke, Franziska +4 more·2023·Langenbeck's Archives of Surgery
DOI 10.1007/s00423-023-03041-wPMC PMC10519863
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Abstract

Introduction: Early detection of severe complications may reduce morbidity and mortality in patients undergoing hepatic resection. Therefore, we prospectively evaluated a panel of inflammatory blood markers for their value in predicting postoperative complications in patients undergoing liver surgery. Methods: A total of 139 patients undergoing liver resections (45 wedge resections, 49 minor resections, and 45 major resections) were prospectively enrolled between August 2017 and December 2018. Leukocytes, CRP, neutrophil-lymphocyte ratio (NLR), thrombocyte-lymphocyte ratio (TLR), bilirubin, INR, and interleukin-6 and -8 (IL-6 and IL-8) were measured in blood drawn preoperatively and on postoperative days 1, 4, and 7. IL-6 and IL-8 were measured using standardized immunoassays approved for in vitro diagnostic use in Germany. ROC curve analysis was used to determine predictive values for the occurrence of severe postoperative complications (CDC ≥ 3). Results: For wedge and minor resections, leukocyte counts at day 7 (AUC 0.80 and 0.82, respectively), IL-6 at day 7 (AUC 0.74 and 0.73, respectively), and CRP change (∆CRP) at day 7 (AUC 0.72 and 0.71, respectively) were significant predictors of severe postoperative complications. IL-8 failed in patients undergoing wedge resections, but was a significant predictor of severe complications after minor resections on day 7 (AUC 0.79), had the best predictive value in all patients on days 1, 4, and 7 (AUC 0.72, 0.72, and 0.80, respectively), and was the only marker with a significant predictive value in patients undergoing major liver resections (AUC on day 1: 0.70, day 4: 0.86, and day 7: 0.92). No other marker, especially not CRP, was predictive of severe complications after major liver surgery. Conclusion: IL-8 is superior to CRP in predicting severe complications in patients undergoing major hepatic resection and should be evaluated as a biomarker for patients undergoing major liver surgery. This is the first paper demonstrating a feasible implementation of IL-8 analysis in a clinical setting.

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Cited by

Sorted by citations

Authors
Pecqueux, M., Brückner, F., Bogner, A., Oehme, F., Hau, H., von Bechtolsheim, F., Held, H., Baenke, F., Distler, M., Riediger, C., Weitz, J., & Kahlert, C.
Affiliations
German Cancer Research Center (DE)
Corresponding author
Kahlert, Christoph
ORCID
Venue
Langenbeck's Archives of Surgery
Publisher
Springer Science and Business Media LLC
Published
2023-09-25
Volume
408
Issue
1
Pages
377-377
ISSN
  • 0023-8236 (ISSN-L)
  • 1435-2451
DOI
10.1007/s00423-023-03041-w
PMC
PMC10519863
OpenAlex
W4387003038
Cited by
4
References
0
Citations by year
2025: 3 · 2024: 1
FWCI
0.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Langenbeck s Archives of Surgery (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Qucosa (Saxon State and University Library Dresden) (submittedVersion, cc-by)
Funders
Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden
Topics
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords
interleukin-8, interleukin-6, C-reactive protein, postoperative complications, major hepatectomy, hepatectomy, inflammatory markers, neutrophil-to-lymphocyte ratio, white blood cell count, complication prediction, wedge resection, prognostic factors
MeSH terms
C-Reactive Protein, Humans, Liver, Postoperative Complications, Prospective Studies, Interleukin-6, Interleukin-8

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