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Cited by 176Ion Transport and Channel RegulationIon channel regulation and functionCellular Mechanics and Interactions

Cells move when ions and water flow

Schwab, Albrecht, Nechyporuk-Zloy, Volodymyr, Fabian, Anke, Stock, Christian·2006·Pflügers Archiv - European Journal of Physiology
DOI 10.1007/s00424-006-0138-6
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Abstract

Cell migration is a process that plays an important role throughout the entire life span. It starts early on during embryogenesis and contributes to shaping our body. Migrating cells are involved in maintaining the integrity of our body, for instance, by defending it against invading pathogens. On the other side, migration of tumor cells may have lethal consequences when tumors spread metastatically. Thus, there is a strong interest in unraveling the cellular mechanisms underlying cell migration. The purpose of this review is to illustrate the functional importance of ion and water channels as part of the cellular migration machinery. Ion and water flow is required for optimal migration, and the inhibition or genetic ablation of channels leads to a marked impairment of migration. We briefly touch cytoskeletal mechanisms of migration as well as cell-matrix interactions. We then present some general principles by which channels can affect cell migration before we discuss each channel group separately.

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Crossref · 10.1007/s00424-006-0138-6

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  • Changes in Vm control critical cell functions including proliferation, migration, and differentiation.

    “Since then, changes in Vm, representing the long-term, slowly changing bioelectric gradient in non-excitable cells (Lobikin et al., 2012), have been shown to control critical cell functions including proliferation, migration, and differentiation (Binggeli and Weinstein, 1986; Schwab et al., 2007; Blackiston et al., 2009; Sundelacruz et al., 2009).”

    From Membrane potential and cancer progression (2013) · cites this paper as Schwab et al., 2007

  • Vm modulates important cellular activities, such as proliferation and differentiation.

    “changes in Vm, representing the long-term, slowly changing bioelectric gradient in non-excitable cells (Lobikin et al., 2012), have been shown to control critical cell functions including proliferation, migration, and differentiation (Binggeli and Weinstein, 1986; Schwab et al., 2007; Blackiston et al., 2009; Sundelacruz et al., 2009).”

    From Membrane potential and cancer progression (2013) · cites this paper as Schwab et al., 2007

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Authors
Schwab, A., Nechyporuk-Zloy, V., Fabian, A., & Stock, C.
Affiliations
University of Münster (DE)
Corresponding author
Schwab, Albrecht
ORCID
Venue
Pflügers Archiv - European Journal of Physiology
Publisher
Springer Science and Business Media LLC
Published
2006-10-05
Volume
453
Issue
4
Pages
421-432
ISSN
  • 0031-6768 (ISSN-L)
  • 1432-2013
DOI
10.1007/s00424-006-0138-6
OpenAlex
W2019631026
Cited by
176
References
1
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 14 · 2013: 18 · 2012: 15
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Pflügers Archiv - European Journal of Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Westfälische Wilhelms-Universität Münster
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
cell migration, ion channels, aquaporins, ion flow, water flow, cytoskeleton, cell-matrix interactions, metastasis, embryonic development, immune defense
MeSH terms
Animals, Cell Movement, Cytoskeleton, Humans, Ion Channels, Models, Biological, Water

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