CoChat
Sign Up
Cited by 69Neurobiology and Insect Physiology ResearchIon Channels and ReceptorsGenetics, Aging, and Longevity in Model Organisms

The extraordinary AFD thermosensor of C. elegans

Open access
Goodman, Miriam B., Sengupta, Piali·2018·Pflügers Archiv - European Journal of Physiology
DOI 10.1007/s00424-017-2089-5PMC PMC5945307
Open this paper in CoChat — free account

Abstract

The nematode C. elegans exhibits complex thermal experience-dependent navigation behaviors in response to environmental temperature changes of as little as 0.01°C over a > 10°C temperature range. The remarkable thermosensory abilities of this animal are mediated primarily via the single pair of AFD sensory neurons in its head. In this review, we describe the contributions of AFD to thermosensory behaviors and temperature-dependent regulation of organismal physiology. We also discuss the mechanisms that enable this neuron type to adapt to recent temperature experience and to exhibit extraordinary thermosensitivity over a wide dynamic range.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00424-017-2089-5

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Many biological processes vary considerably over 4-5 °C, well within the range of what is normally considered room temperature.

    “because many biological processes vary considerably over 4-5 • C [40,55-59], well within the range of what is normally considered room temperature.”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [56]

    The ‘Regulation of systemic temperature responses by AFD’ section says physiological and biochemical processes are temperature-sensitive, and ‘Thermosensory navigation behaviors’ describes a C. elegans behavior within roughly 2°C of either side of its prior temperature. The paper does not establish that many biological processes vary considerably across a 4–5°C range, or define that range as room temperature. Page numbers were not available in our copy. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 95

  1. [1]Andersen EC Gerke JP Shapiro JA Crissman JR Ghosh R Bloom JS Felix MA Kruglyak L 2012 Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity Nat Genet 44 285 290 22286215 PMC3365839
  2. [2]Anderson JL Albergotti L Ellebracht B Huey RB Phillips PC 2011 Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans? BMC Evol Biol 11 157 21645395 PMC3141425
  3. [3]Angilletta MJ 2009 Thermal Adaptation: A theoretical and empirical synthesis Oxford University Press Oxford, UK
  4. [4]Arshavsky VY Burns ME 2012 Photoreceptor signaling: supporting vision across a wide range of light intensities J Biol Chem 287 1620 1626 22074925 PMC3265842
  5. [5]Bacaj T Tevlin M Lu Y Shaham S 2008 Glia are essential for sensory organ function in C. elegans Science 322 744 747 18974354 PMC2735448
  6. [6]Beverly M Anbil S Sengupta P 2011 Degeneracy and signaling within a sensory circuit contributes to robustness in thermosensory behaviors in C. elegans J Neurosci 31 11718 11727 21832201 PMC3167209
  7. [7]Biron D Shibuya M Gabel C Wasserman SM Clark DA Brown A Sengupta P Samuel AD 2006 A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans Nat Neurosci 9 1499 1505 17086178
  8. [8]Biron D Wasserman SM Thomas JH Samuel AD Sengupta P 2008 An olfactory neuron responds stochastically to temperature and modulates C. elegans thermotactic behavior Proc Natl Acad Sci USA 105 11002 11007 18667708 PMC2504807
  9. [9]Bradley J Reuter D Frings S 2001 Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits Science 294 2176 2178 11739960
  10. [10]Bretscher AJ Kodama-Namba E Busch KE Murphy RJ Soltesz Z Laurent P de Bono M 2011 Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior Neuron 69 1099 1113 21435556 PMC3115024
  11. [11]Busch KE Laurent P Soltesz Z Murphy RJ Faivre O Hedwig B Thomas M Smith HL de Bono M 2012 Tonic signaling from O(2) sensors sets neural circuit activity and behavioral state Nat Neurosci 15 581 591 22388961 PMC3564487
  12. [12]Chao YC Chen CC Lin YC Breer H Fleischer J Yang RB 2015 Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures EMBO J 34 294 306 25452496 PMC4339118
  13. [13]Chen TY Yau KW 1994 Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons Nature 368 545 548 7511217
  14. [14]Chen YC Chen HJ Tseng WC Hsu JM Huang TT Chen CH Pan CL 2016 A C elegans thermosensory circuit regulates longevity through crh-1/CREB-dependent flp-6 neuropeptide signaling Dev Cell 39 209 223 27720609
  15. [15]Chi CA Clark DA Lee S Biron D Luo L Gabel CV Brown J Sengupta P Samuel AD 2007 Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans J Exp Biol 210 4043 4052 17981872
  16. [16]Cho SW Choi KY Park CS 2004 A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans Biochem Biophys Res Commun 325 525 531 15530424
  17. [17]Clark DA Biron D Sengupta P Samuel ADT 2006 The AFD sensory neurons encode multiple functions underlying thermotactic behavior in C. elegans J Neurosci 26 7444 7451 16837592 PMC6674189
  18. [18]Clark DA Gabel CV Gabel H Samuel AD 2007 Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients J Neurosci 27 6083 6090 17553981 PMC6672141
  19. [19]Clark DA Gabel CV Lee TM Samuel AD 2007 Short-term adaptation and temporal processing in the cryophilic response of Caenorhabditis elegans J Neurophysiol 97 1903 1910 17151225
  20. [20]Coburn CM Bargmann CI 1996 A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans Neuron 17 695 706 8893026
  21. [21]Doroquez DB Berciu C Anderson JR Sengupta P Nicastro D 2014 A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in C. elegans eLife 3 e01948 24668170 PMC3965213
  22. [22]Felix MA Braendle C 2010 The natural history of Caenorhabditis elegans Curr Biol 20 R965 969 21093785
  23. [23]Flouris AD Piantoni C 2015 Links between thermoregulation and aging in endotherms and ectotherms Temperature 2 73 85 PMC4843886 27226994
  24. [24]Frezal L Felix MA 2015 C. elegans outside the Petri dish eLife 4 05849 PMC4373675 25822066
  25. [25]Frokjaer-Jensen C Kindt KS Kerr RA Suzuki H Melnik-Martinez K Gerstbreih B Driscol M Schafer WR 2006 Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons J Neurobiol 66 1125 1139 16838374
  26. [26]Guven-Ozkan T Davis RL 2014 Functional neuroanatomy of Drosophila olfactory memory formation Learn Mem 21 519 526 25225297 PMC4175493
  27. [27]Hawkins RD Kandel ER Bailey CH 2006 Molecular mechanisms of memory storage in Aplysia Biol Bullet 210 174 191 16801493
  28. [28]Hecht S Shlaer S Pirenne MH 1942 Energy, Quanta, and Vision J Gen Physiol 25 819 840 19873316 PMC2142545
  29. [29]Hedgecock EM Russell RL 1975 Normal and mutant thermotaxis in the nematode Caenorhabditis elegans Proc Natl Acad Sci USA 72 4061 4065 1060088 PMC433138
  30. [30]Hodgkin J Doniach T 1997 Natural variation and copulatory plug formation in Caenorhabditis elegans Genetics 146 149 164 9136008 PMC1207933
  31. [31]Holmes R Victora M Wang RF Kwiat PG 2017 Measuring temporal summation in visual detection with a single-photon source Vision Res 140 33 43 28803949
  32. [32]Huganir RL Nicoll RA 2013 AMPARs and synaptic plasticity: the last 25 years Neuron 80 704 717 24183021 PMC4195488
  33. [33]Inada H Ito H Satterlee J Sengupta P Matsumoto K Mori I 2006 Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans Genetics 172 2239 2252 16415369 PMC1456394
  34. [34]Jurado P Kodama E Tanizawa Y Mori I 2010 Distinct thermal migration behaviors in response to different thermal gradients in Caenorhabditis elegans Genes Brain Behav 9 120 127 20002199
  35. [35]Kimura KD Miyawaki A Matsumoto K Mori I 2004 The C. elegans thermosensory neuron AFD responds to warming Curr Biol 14 1291 1295 15268861
  36. [36]Kiontke KC Felix MA Ailion M Rockman MV Braendle C Penigault JB Fitch DH 2011 A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits BMC Evol Biol 11 339 22103856 PMC3277298
  37. [37]Klass MR 1977 Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span Mech Ageing Dev 6 413 429 926867
  38. [38]Kobayashi K Nakano S Amano M Tsuboi D Nishioka T Ikeda S Yokoyama G Kaibuchi K Mori I 2016 Single-cell memory regulates a neural circuit for sensory behavior Cell Rep 14 11 21 26725111
  39. [39]Koch KW Dell’Orco D 2015 Protein and signaling networks in vertebrate photoreceptor cells Front Molec Neurosci 8 67 26635520 PMC4646965
  40. [40]Komatsu H Jin YH L’Etoile N Mori I Bargmann CI Akaike N Ohshima Y 1999 Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells Brain Res 821 160 168 10064800
  41. [41]Komatsu H Mori I Ohshima Y 1996 Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans Neuron 17 707 718 8893027
  42. [42]Kuhara A Okumura M Kimata T Tanizawa Y Takano R Kimura KD Inada H Matsumoto K Mori I 2008 Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans Science 320 803 807 18403676
  43. [43]Kuhn M 2016 Molecular physiology of membrane guanylyl cyclase receptors Physiol Rev 96 751 804 27030537
  44. [44]L’Etoile ND Coburn CM Eastham J Kistler A Gallegos G Bargmann CI 2002 The cyclic GMP-dependent protein kinase EGL-4 regulates olfactory adaptation in C. elegans Neuron 36 1079 1089 12495623
  45. [45]Land M Rubin CS 2017 A Calcium- and diacylglycerol-stimulated protein kinase C (PKC), Caenorhabditis elegans PKC-2, links thermal signals to learned behavior by acting in sensory neurons and intestinal cells Mol Cell Biol 37 e00192 17 28716951 PMC5599713
  46. [46]Larsch J Flavell SW Liu Q Gordus A Albrecht DR Bargmann CI 2015 A circuit for gradient climbing in C. elegans chemotaxis Cell Rep 12 1748 1760 26365196 PMC5045890
  47. [47]Lee SJ Kenyon C 2009 Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans Curr Biol 19 715 722 19375320 PMC2868911
  48. [48]Li M Zhou X Wang S Michailidis I Gong Y Su D Li H Li X Yang J 2017 Structure of a eukaryotic cyclic-nucleotide-gated channel Nature 542 60 65 28099415 PMC5783306
  49. [49]Lim S Dizhoor AM Ames JB 2014 Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1 Front Molec Neurosci 7 19 24672427 PMC3956117
  50. [50]Loeb J Northrop JH 1916 Is there a temperature coefficient for the duration of life? Proc Natl Acad Sci USA 2 456 457 16586628 PMC1091065
  51. [51]Luo L Clark DA Biron D Mahadevan L Samuel AD 2006 Sensorimotor control during isothermal tracking in Caenorhabditis elegans J Exp Biol 209 4652 4662 17114399
  52. [52]Luo L Cook N Venkatachalam V Martinez-Velazquez LA Zhang X Calvo AC Hawk J Macinnis BL Frank M Ng JH Klein M Gershow M Hammarlund M Goodman MB Colon-Ramos DA Zhang Y Samuel AD 2014 Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons Proc Natl Acad Sci USA 111 2776 2781 24550307 PMC3932917
  53. [53]Mori I Ohshima Y 1995 Neural regulation of thermotaxis in Caenorhabditis elegans Nature 376 344 348 7630402
  54. [54]Munger SD Lane AP Zhong H Leinders-Zufall T Yau KW Zufall F Reed RR 2001 Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation Science 294 2172 2175 11739959 PMC2885906
  55. [55]Narayan A Laurent G Sternberg PW 2011 Transfer characteristics of a thermosensory synapse in Caenorhabditis elegans Proc Natl Acad Sci USA 108 9667 9672 21606366 PMC3111291
  56. [56]Nguyen PA Liou W Hall DH Leroux MR 2014 Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron J Cell Sci 127 5317 5330 25335890 PMC4265742
  57. [57]Nishida Y Sugi T Nonomura M Mori I 2011 Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis EMBO Rep 12 855 862 21738224 PMC3147260
  58. [58]O’Halloran DM Altshuler-Keylin S Zhang XD He C Morales-Phan C Yu Y Kaye JA Brueggemann C Chen TY L’Etoile ND 2017 Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans Sci Rep 7 169 28279024 PMC5427828
  59. [59]Ohnishi N Kuhara A Nakamura F Okochi Y Mori I 2011 Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans EMBO J 30 1376 1388 21304490 PMC3094115
  60. [60]Ohta A Ujisawa T Sonoda S Kuhara A 2014 Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans Nat Commun 5 4412 25048458 PMC4109018
  61. [61]Okochi Y Kimura KD Ohta A Mori I 2005 Diverse regulation of sensory signaling by C. elegans nPKC-epsilon/eta TTX-4 EMBO J 24 2127 2137 15920475 PMC1150891
  62. [62]Ortiz CO Etchberger JF Posy SL Frokjaer-Jensen C Lockery S Honig B Hobert O 2006 Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases Genetics 173 131 149 16547101 PMC1461427
  63. [63]Paoletti P Young EC Siegelbaum SA 1999 C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating J Gen Physiol 113 17 34 9874685 PMC2222991
  64. [64]Perkins LA Hedgecock EM Thomson JN Culotti JG 1986 Mutant sensory cilia in the nematode Caenorhabditis elegans Dev Biol 117 456 487 2428682
  65. [65]Prahlad V Cornelius T Morimoto RI 2008 Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons Science 320 811 814 18467592 PMC3429343
  66. [66]Pugh EN Jr Nikonov S Lamb TD 1999 Molecular mechanisms of vertebrate photoreceptor light adaptation Curr Opin Neurobiol 9 410 418 10448166
  67. [67]Ramot D MacInnis BL Goodman MB 2008 Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans Nat Neurosci 11 908 915 18660808 PMC2587641
  68. [68]Ramot D MacInnis BL Lee HC Goodman MB 2008 Thermotaxis is a robust mechanism for thermoregulation in Caenorhabditis elegans nematodes J Neurosci 28 12546 12557 19020047 PMC3899394
  69. [69]Russell J Vidal-Gadea AG Makay A Lanam C Pierce-Shimomura JT 2014 Humidity sensation requires both mechanosensory and thermosensory pathways in Caenorhabditis elegans Proc Natl Acad Sci USA 111 8269 8274 24843133 PMC4050571
  70. [70]Ryu WS Samuel AD 2002 Thermotaxis in Caenorhabditis elegans analyzed by measuring responses to defined thermal stimuli J Neurosci 22 5727 5733 12097525 PMC6758190
  71. [71]Satterlee JS Ryu WS Sengupta P 2004 The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans Curr Biol 14 62 68 14711416
  72. [72]Schaad NC De Castro E Nef S Hegi S Hinrichsen R Martone ME Ellisman MH Sikkink R Rusnak F Sygush J Nef P 1996 Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1 Proc Natl Acad Sci USA 93 9253 9258 8799187 PMC38628
  73. [73]Schulenburg H Felix MA 2017 The natural biotic environment of Caenorhabditis elegans Genetics 206 55 86 28476862 PMC5419493
  74. [74]Sharma RK Duda T 2012 Ca(2+)-sensors and ROS-GC: interlocked sensory transduction elements: a review Front Molec Neurosci 5 42 22509149 PMC3321474
  75. [75]Sharma RK Duda T Makino CL 2016 Integrative signaling networks of membrane guanylate cyclases: Biochemistry and physiology Front Molec Neurosci 9 83 27695398 PMC5023690
  76. [76]Singhvi A Liu B Friedman CJ Fong J Lu Y Huang XY Shaham S 2016 A glial K/Cl transporter controls neuronal receptive ending shape by chloride inhibition of an rGC Cell 165 936 948 27062922 PMC4860081
  77. [77]Sugi T Nishida Y Mori I 2011 Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans Nat Neurosci 14 984 992 21706021
  78. [78]Takeishi A Yu YV Hapiak V Bell HW O’Leary T Sengupta P 2016 Receptor guanylyl cyclases confer thermosensory responses in C. elegans Neuron 90 235 244 27041501 PMC4840083
  79. [79]Tanimoto Y Yamazoe-Umemoto A Fujita K Kawazoe Y Miyanishi Y Yamazaki SJ Fei X Busch KE Gengyo-Ando K Nakai J Iino Y Iwasaki Y Hashimoto K Kimura KD 2017 Calcium dynamics regulating the timing of decision-making in C. elegans eLife 6 e21629 28532547 PMC5441874
  80. [80]Tattersall GJ Sinclair BJ Withers PC Fields PA Seebacher F Cooper CE Maloney SK 2012 Coping with thermal challenges: physiological adaptations to environmental temperatures Compr Physiol 2 2151 2202 23723035
  81. [81]Tatum MC Ooi FK Chikka MR Chauve L Martinez-Velazquez LA Steinbusch HW Morimoto RI Prahlad V 2015 Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase Curr Biol 25 163 174 25557666 PMC4840938
  82. [82]Tinsley JN Molodtsov MI Prevedel R Wartmann D Espigule-Pons J Lauwers M Vaziri A 2016 Direct detection of a single photon by humans Nat Commun 7 12172 27434854 PMC4960318
  83. [83]Tsukada Y Yamao M Naoki H Shimowada T Ohnishi N Kuhara A Ishii S Mori I 2016 Reconstruction of spatial thermal gradient encoded in thermosensory neuron AFD in Caenorhabditis elegans J Neurosci 36 2571 2581 26936999 PMC4879206
  84. [84]Van Voorhies WA Ward S 1999 Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate Proc Natl Acad Sci USA 96 11399 11403 10500188 PMC18045
  85. [85]Venkatachalam V Ji N Wang X Clark C Mitchell JK Klein M Tabone CJ Florman J Ji H Greenwood J Chisholm AD Srinivasan J Alkema M Zhen M Samuel AD 2016 Pan-neuronal imaging in roaming Caenorhabditis elegans Proc Natl Acad Sci U S A 113 E1082 1088 10.1073/pnas.1507109113 26711989 PMC4776525 · DOI
  86. [86]Vidal-Gadea A Ward K Beron C Ghorashian N Gokce S Russell J Truong N Parikh A Gadea O Ben-Yakar A Pierce-Shimomura J 2015 Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans Elife 4 10.7554/eLife.07493 PMC4525075 26083711 · DOI
  87. [87]Voets T 2012 Quantifying and modeling the temperature-dependent gating of TRP channels Reviews of physiology, biochemistry and pharmacology 162 91 119 10.1007/112_2011_5 22298025 · DOI
  88. [88]Wang D O’Halloran D Goodman MB 2013 GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis J Gen Physiol 142 437 449 10.1085/jgp.201310959 24081984 PMC3787776 · DOI
  89. [89]Ward S Thomson N White JG Brenner S 1975 Electron microscopical reconstruction of the anterior sensory anatomy of the nematode Caenorhabditis elegans J Comp Neurol 160 313 337 1112927
  90. [90]Wasserman SM Beverly M Bell HW Sengupta P 2011 Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling Curr Biol 21 353 362 21315599 PMC3057529
  91. [92]Xiao R Zhang B Dong Y Gong J Xu T Liu J Xu XZ 2013 A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel Cell 152 806 817 10.1016/j.cell.2013.01.020 23415228 PMC3594097 · DOI
  92. [93]Yoshida A Nakano S Suzuki T Ihara K Higashiyama T Mori I 2015 A glial K /Cl cotransporter modifies temperature-evoked dynamics in C. elegans sensory neurons Genes Brain Behav 15 429 440 10.1111/gbb.12260 26463820 · DOI
  93. [94]Yu S Avery L Baude E Garbers DA 1997 Guanylyl cyclase expression in specific sensory neurons: A new family of chemosensory receptors Proc Natl Acad Sci USA 94 3384 3387 9096403 PMC20379
  94. [95]Yu YV Bell HW Glauser DA Goodman MB Van Hooser SD Sengupta P 2014 CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron Neuron 84 919 926 25467978 PMC4258139
  95. [96]Zahratka JA Williams PD Summers PJ Komuniecki RW Bamber BA 2015 Serotonin differentially modulates Ca2+ transients and depolarization in a C. elegans nociceptor J Neurophysiol 113 1041 1050 10.1152/jn.00665.2014 25411461 PMC4329441 · DOI

Cited by

Sorted by citations

Authors
Goodman, M. B., & Sengupta, P.
Affiliations
  • Stanford University (US)
  • Brandeis University (US)
Corresponding author
  • Goodman, Miriam B.
  • Sengupta, Piali
ORCID
Venue
Pflügers Archiv - European Journal of Physiology
Publisher
Springer Science and Business Media LLC
Published
2017-12-08
Volume
470
Issue
5
Pages
839-849
ISSN
  • 0031-6768 (ISSN-L)
  • 1432-2013
DOI
10.1007/s00424-017-2089-5
PMC
PMC5945307
OpenAlex
W2771210843
Cited by
69
References
1
Citations by year
2026: 12 · 2025: 10 · 2024: 12 · 2023: 6 · 2022: 9 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 4
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Pflügers Archiv - European Journal of Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (R35 GM22463, P01 GM103770)
  • National Institute of Neurological Disorders and Stroke (R01 NS047715)
  • G. Harold and Leila Y. Mathers Charitable Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
Caenorhabditis elegans, thermosensation, temperature dependence, thermal adaptation, thermosensitivity, sensory neurons
MeSH terms
Adaptation, Physiological, Animals, Synaptic Transmission, Sensory Receptor Cells, Thermosensing, Caenorhabditis elegans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review