Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion
Abstract
The objective of the current study was to investigate the expression pattern of Tbx3 and its clinicopathological significance in patients with gastric cancer. The expression pattern of Tbx3 in gastric cancer tissues and adjacent noncancerous surface epithelia and mucosal glands was detected by immunohistochemistry. Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples, and this correlated with advanced clinical stage, tumor stage, and nodal status. In addition, in the SGC-7901 gastric cancer cell line, Tbx3 overexpression by plasmid transfection promoted growth and invasion. Conversely, depleting Tbx3 expression by small-interfering RNA inhibited proliferation and invasion in BGC-823 cell line. Moreover, Tbx3 accelerated cell cycle progression at the G1/S boundary. Tbx3 also regulated epithelial-to-mesenchymal transition (EMT) to promote cell invasion by repressing E-cadherin expression and increasing expression levels N-cadherin, vimentin. These results indicate that in gastric cancer, Tbx3 plays an important role and might be a useful therapy target.
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Tbx3 is involved in the carcinogenesis of multiple types of human cancers.
“As Tbx3 is involved in the carcinogenesis of multiple types of human cancers, our findings suggest an important target for anti-cancer drug development.”
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References 30 · Cited by 20
- Authors
- Miao, Z.-F., Liu, X.-Y., Xu, H.-M., Wang, Z.-N., Zhao, T.-T., Song, Y.-X., Xing, Y.-N., Huang, J.-Y., Zhang, J.-Y., Xu, H., & Xu, Y.-Y.
- Affiliations
- First Hospital of China Medical University (CN)
- Venue
- Virchows Archiv
- Published
- 2016-08-24
- Volume
- 469
- Issue
- 5
- Pages
- 505-513
- ISSN
- 0945-6317 (ISSN-L)
- 1432-2307
- OpenAlex
- W2508990219
- Cited by
- 20
- References
- 30
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81272718, 81302125, 81372550)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- TBX3, gastric cancer, gene overexpression, tumor stage, lymph node metastasis, cell proliferation, cell invasion, epithelial-mesenchymal transition, E-cadherin, N-cadherin, vimentin, G1/S cell cycle progression, therapeutic target
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cell Movement, Cell Transformation, Neoplastic, Female, Humans, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Stomach Neoplasms, Gene Expression Regulation, Neoplastic, T-Box Domain Proteins, RNA, Small Interfering, Cell Line, Tumor, Cell Proliferation, Epithelial-Mesenchymal Transition
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