Clinical effects of insular damage in humans
Open accessAbstract
Multiple disturbances following lesions of the insula are reviewed in the present article, including those related to autonomic function; gustatory, olfactory, auditory, somatosensory, and multimodal perception, as well as body awareness; the emotion of disgust; mood and willed action, addiction behavior, and language. Given the multiple and varied nature of the impairments revealed by lesion studies, we suggest that the insula, as a multimodal area, has a major role as a convergence zone implicated in the coordination between internal and external information through emotional subjective awareness. Methodological issues are discussed with attention paid to lesion etiology, and lesions involving adjacent areas to the insular cortex.
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Interoceptive deficits following lesions, especially to the AI and ACC, are well documented.
“Interoceptive deficits following lesions, especially to the AI and ACC, are well documented (Ibañez et al., 2010), but the nature of the development of interoceptive difficulties in the absence of brain trauma requires further investigation”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Ibañez et al., 2010
The insula has long been recognized as a key player in sensory, affective, and cognitive processes, including sensory processing, homeostasis, emotions, motivation, decision-making, chronic pain, anxiety, depression, addiction, and eating disorders.
“The insular cortex, also known as the insula, has long been recognized as a key player in various sensory, affective, and cognitive processes, ranging from basic functions including sensory processing, bodily homeostasis, emotions, motivation, and decision-making, to maladaptive conditions including chronic pain, anxiety, depression, drug addiction, and eating disorders [1][2][3][4][5][6][7][8][9]”
From The Insular Cortex: An Interface Between Sensation, Emotion and Cognition (2024) · cites this paper as [3]
Emotion recognition and empathic deficits occur after insular cortex lesions.
“emotion recognition and empathic deficits occur after insular cortex lesions3–5”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [4]
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References 132 · Cited by 217
- Authors
- Ibañez, A., Gleichgerrcht, E., & Manes, F.
- Affiliations
- Instituto de Neurología Cognitiva (AR)
- Favaloro University (AR)
- Corresponding author
- Manes, Facundo
- Venue
- Brain Structure and Function
- Published
- 2010-05-29
- Volume
- 214
- Issue
- 5-6
- Pages
- 397-410
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W1973712602
- Cited by
- 217
- References
- 132
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 26 · 2021: 12 · 2020: 13 · 2019: 11 · 2018: 15 · 2017: 14 · 2016: 10 · 2015: 16 · 2014: 22 · 2013: 9 · 2012: 19
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- insula, autonomic function, taste perception, olfaction, auditory perception, somatosensory perception, body awareness, disgust, mood, addictive behavior, language, multimodal integration, emotional awareness
- MeSH terms
- Animals, Awareness, Brain Damage, Chronic, Cerebral Cortex, Humans, Nerve Net, Pain, Perception
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