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Cited by 132Glutathione Transferases and PolymorphismsPharmacogenetics and Drug MetabolismGenetic Associations and Epidemiology

Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma

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Munaka, Masahiro, Kohshi, Kiyotaka, Kawamoto, Toshihiro, Takasawa, Shin, Nagata, Naoki, Itoh, Hideaki, Oda, Susumu, Katoh, Takahiko·2003·Journal of Cancer Research and Clinical Oncology
DOI 10.1007/s00432-003-0439-5PMC PMC12162083
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Abstract

The effect of genetic polymorphisms for glutathione S-transferase ( GST) M1, GSTT1, GSTP1-1( GSTP1), cytochrome P450 2E1 ( CYP2E1) and aldehyde dehydrogenase 2 ( ALDH2) on the risk of hepatocellular carcinoma (HCC) was observed in 78 Japanese patients with HCC and 138 non-cancer hospital controls. We found a positive association between cumulative amounts of alcohol consumption (>/=600,000 ml in a lifetime) and the risk of HCC (OR=4.52, 95% CI 2.39-8.55). However, cigarette smoking was not significantly related to the risk of HCC (OR=1.23, 95% CI 0.57-2.68). The allelic frequencies of GSTM1, GSTT1, GSTP1, CYP2E1and ALDH2of HCC patients were not significantly different from those of controls when odds ratios were only adjusted for age and gender except for any 2 alleles of ALDH2in drinkers (OR=2.53, 95% CI 1.21-5.31). However, the frequency of any C2 alleles of CYP2E1and any 2 alleles of ALDH2were significantly higher than those of controls (OR=5.77, 95% CI 1.24-27.39, OR=9.77, 95% CI 1.63-58.60) when covariates including viremia were selected by using stepwise logistic regression analysis. We conclude that habitual alcohol drinking is likely to lead to an increased risk of HCC, and any C2alleles of CYP2E1as well as any two alleles of ALDH2were also associated with an increased risk of HCC.

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  • ALDH2*2 allele is associated with a high incidence of liver cancer in heavy drinkers.

    “The ALDH2 mutant genotype, ALDH2*2 allele (also known as ALDH2(E487K) or ALDH2 rs671 polymorphism), has been found to be associated with a high incidence of liver cancer in heavy drinkers [118,119,120].”

    From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [118]

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Authors
Munaka, M., Kohshi, K., Kawamoto, T., Takasawa, S., Nagata, N., Itoh, H., Oda, S., & Katoh, T.
Affiliations
  • Nissan (Japan) (JP)
  • University of Occupational and Environmental Health Japan (JP)
  • University of Miyazaki (JP)
Corresponding author
Katoh, Takahiko
ORCID
Venue
Journal of Cancer Research and Clinical Oncology
Publisher
Springer Science and Business Media LLC
Published
2003-06-01
Volume
129
Issue
6
Pages
355-360
ISSN
  • 0084-5353 (ISSN-L)
  • 0171-5216
  • 1432-1335
DOI
10.1007/s00432-003-0439-5
PMC
PMC12162083
OpenAlex
W2064057901
Cited by
132
References
0
Citations by year
2026: 4 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 13 · 2014: 6 · 2013: 4 · 2012: 14
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Cancer Research and Clinical Oncology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
hepatocellular carcinoma, genetic polymorphism, alcohol consumption, cigarette smoking, glutathione S-transferase, GSTM1, GSTT1, GSTP1, CYP2E1, ALDH2, Japanese patients, viremia
MeSH terms
Aldehyde Dehydrogenase, Mitochondrial, Adult, Aged, Aged, 80 and over, Alcohol Drinking, Aldehyde Dehydrogenase, Female, Glutathione Transferase, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Smoking, Cytochrome P-450 CYP2E1, Genetic Predisposition to Disease

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