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Cited by 50Acne and Rosacea Treatments and EffectsGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

A genome-wide association study of severe teenage acne in European Americans

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Zhang, Mingfeng, Qureshi, Abrar A., Hunter, David J., Han, Jiali·2014·Human Genetics
DOI 10.1007/s00439-013-1374-4PMC PMC3945714
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Abstract

Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 European Americans. The SNP rs4133274 on chromosome 8q24 (72 kb upstream of MYC) revealed the most significant association with severe teenage acne (p value = 1.7 × 10(-6)). The variant allele of this SNP (G allele) was associated with an increased risk of severe teenage acne with odds ratio of 4.01 (95 % confidence interval = 2.37-6.82). Upon further replication, our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studies.

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Cited by

Sorted by citations

Authors
Zhang, M., Qureshi, A. A., Hunter, D. J., & Han, J.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Han, Jiali
ORCID
Venue
Human Genetics
Publisher
Springer Science and Business Media LLC
Published
2013-10-11
Volume
133
Issue
3
Pages
259-264
ISSN
  • 0018-7348 (ISSN-L)
  • 0340-6717
  • 1432-1203
DOI
10.1007/s00439-013-1374-4
PMC
PMC3945714
OpenAlex
W2040332667
Cited by
50
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 10 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 2
FWCI
5.09
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Human Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (U01CA067262, CA67262, CA50385, UM1CA176726, R01CA050385, R01CA122838, R01CA067262)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords
acne, genetic susceptibility, c-Myc, chromosome 8q24, European Americans, familial aggregation
MeSH terms
Acne Vulgaris, Adolescent, Adult, Alleles, Chromosomes, Human, Pair 8, Female, Gene Frequency, Genetic Markers, Genotype, Humans, Prospective Studies, Quality Control, Risk Factors, United States, Logistic Models, Odds Ratio, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, White People, Genome-Wide Association Study, Young Adult, Genetic Loci

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