NF-κB and STAT3 signaling hubs for lung innate immunity
Abstract
Innate immune responses to lung pathogens involve the coordinated expression of myriad affector and effector molecules of innate immunity, which must be induced and appropriately regulated in response to diverse stimuli generated by microbes or the infected host. Many intercellular and intracellular signaling pathways are involved, but we propose NF-κB and STAT3 transcription factors to be especially important signaling hubs for integrating these pathways to orchestrate effective host defense without excessive inflammatory injury.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The crosstalk between STAT3 and NF-κB is an active field of research with studies showing contradictory outcomes of concomitant activation of the two TFs.
“The crosstalk between STAT3 and NF-κB is an active field of research with studies showing contradictory outcomes of concomitant activation of the two TFs.”
From Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading (2017) · cites this paper as [17]
Some studies suggest cooperation between STAT3 and NF-κB, while others show antagonism.
“Some suggest cooperation between them, while others show antagonism2, 16–21.”
From Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading (2017) · cites this paper as [17]
Cites
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 1× · see citing works
“The early response cytokines TNFα and IL-1 together with IL-6 are well-recognized activators of APP synthesis in hepatocytes (Andus et al. 1988; Thorn et al. 2004; Kopf et al. 1994; Zahedi and Whitehead 1993).”
BackgroundFunction of Mitochondrial Stat3 in Cellular Respiration
Wegrzyn, J., Potla, R., Chwae, Y.-J., Sepuri, N. B. V., Zhang, Q., Koeck, T., Derecka, M., Szczepanek, K., Szelag, M., Gornicka, A., et al. (2009) · Science · doi:10.1126/science.1164551 · Cited by 1,014 · see citing works
Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584 · see citing works
Bazzoni, F., Rossato, M., Fabbri, M., Gaudiosi, D., Mirolo, M., Mori, L., Tamassia, N., Mantovani, A., Cassatella, M. A., & Locati, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810909106 · Cited by 548 · cited 1× · see citing works
“…of mir-146 (which targets TRAF6 ad IRAK-1 to tune TLR signaling; Taganov et al. 2006), of mir-9 (which targets Nfkb1 to diminish NFκB p50 and p105; Bazzoni et al. 2009), of mir-147 (which limits cytokine expression by as yet unknown means; Liu et al. 2009), of mir-21 (which targets PDCD4 to…”
Background
Flagged first, then by citations
Cited by
Sorted by citations
Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
Mehra, A., Zahra, A., Thompson, V., Sirisaengtaksin, N., Wells, A., Porto, M., Köster, S., Penberthy, K., Kubota, Y., Dricot, A., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003734 · Cited by 192 · see citing works
Goldstein, I., Paakinaho, V., Baek, S., Sung, M.-H., & Hager, G. L. (2017) · Nature Communications · doi:10.1038/s41467-017-02055-5 · Cited by 97 · see citing works
Carroll, J. A., Striebel, J. F., Race, B., Phillips, K., & Chesebro, B. (2015) · Journal of Virology · doi:10.1128/jvi.02952-14 · Cited by 63 · see citing works
- Authors
- Quinton, L. J., & Mizgerd, J. P.
- Affiliations
- Boston University (US)
- Corresponding author
- Mizgerd, Joseph P.
- Venue
- Cell and Tissue Research
- Published
- 2010-09-25
- Volume
- 343
- Issue
- 1
- Pages
- 153-165
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W2080311121
- Cited by
- 65
- References
- 4
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 8 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 9
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R00HL092956)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- NF-κB signaling, STAT3 signaling, lung innate immunity, transcription factors, signaling hubs, inflammation regulation, innate immune response
- MeSH terms
- Animals, Humans, Immunity, Innate, Lung, Organ Specificity, Signal Transduction, NF-kappa B, STAT3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
