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Cited by 12Dysphagia Assessment and ManagementMedication Adherence and CompliancePharmaceutical Practices and Patient Outcomes

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Do Orally Disintegrating Tablets Facilitate Medical Adherence and Clinical Outcomes in Patients with Post-stroke Dysphagia?

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Sato, So, Sasabuchi, Yusuke, Okada, Akira, Yasunaga, Hideo·2025·Dysphagia
DOI 10.1007/s00455-024-10737-8PMC PMC11893695
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Abstract

Orally disintegrating tablets (ODTs) dissolve rapidly in contact with saliva and have been reported to facilitate oral administration of medications in swallowing difficulties. However, their clinical benefits remain unclear because no previous studies have examined whether ODTs facilitate medication adherence and clinical outcomes in patients with post-stroke dysphagia. This study evaluated the association between ODT prescriptions and clinical benefits using high-dimensional propensity score (hd-PS) matching to adjust for confounding factors. Using a large Japanese commercial medical and dental claims database, we identified patients aged ≥ 65 years with post-stroke dysphagia between April 2014 and March 2021. To compare 1-year outcomes of medication adherence, cardiovascular events, and aspiration pneumonia between patients taking ODTs and non-ODTs, we performed hd-PS matching. We identified 11,813 patients without ODTs and 3178 patients with ODTs. After hd-PS matching, 2246 pairs were generated. Medication adherence for 1 year, based on the proportion of days covered, was not significantly different between the non-ODT and ODT groups before (0.887 vs. 0.900, P = 0.999) and after hd-PS matching (0.889 vs. 0.902, P = 0.977). The proportion of cardiovascular events (0.898 vs. 0.893, P = 0.591) and aspiration pneumonia (0.380 vs. 0.372, P = 0.558) were also not significantly different between the groups. This study found no significant differences in medication adherence, cardiovascular diseases, or aspiration pneumonia between the non-ODT and ODT groups in patients with post-stroke dysphagia. Both groups achieved a proportion of days covered exceeding 80%. Clinicians may consider prescribing ODTs or non-ODTs based on patient preferences rather than solely on post-stroke conditions.

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Metadata

Authors
Sato, S., Sasabuchi, Y., Okada, A., & Yasunaga, H.
Affiliations
The University of Tokyo (JP)
Corresponding author
Sato, So
ORCID
Venue
Dysphagia
Publisher
Springer Science and Business Media LLC
Published
2024-08-03
Volume
40
Issue
2
Pages
381-387
ISSN
  • 0179-051X (ISSN-L)
  • 1432-0460
DOI
10.1007/s00455-024-10737-8
PMC
PMC11893695
OpenAlex
W4401299032
Cited by
12
References
28
Citations by year
2026: 7 · 2025: 5
FWCI
7.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Dysphagia (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Ministry of Health, Labour and Welfare (23AA2003)
  • The University of Tokyo
Topics
  • Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
orally disintegrating tablets, post-stroke dysphagia, medication adherence, aspiration pneumonia, cardiovascular events, dysphagia, drug formulation, older adults, proportion of days covered
MeSH terms
Administration, Oral, Aged, Aged, 80 and over, Deglutition Disorders, Female, Humans, Japan, Male, Pneumonia, Aspiration, Retrospective Studies, Tablets, Treatment Outcome, Stroke, Medication Adherence, Propensity Score

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