Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 15

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Reductions in sleep quality and circadian activity rhythmicity predict longitudinal changes in objective and subjective cognitive functioning in women treated for breast cancer

Ancoli-Israel, Sonia, Liu, Lianqi, Natarajan, Loki, Rissling, Michelle, Neikrug, Ariel B., Youngstedt, Shawn D., Mills, Paul J., Sadler, Georgia R., Dimsdale, Joel E., Parker, Barbara A., Palmer, Barton W.·2022·Supportive Care in Cancer
DOI 10.1007/s00520-021-06743-3
Open this paper in CoChat — free account

Abstract

Purpose: To examine long-term cognitive effects of chemotherapy and identify predictors among women with breast cancer (WBC). Patients and methods: Sixty-nine WBC scheduled to receive chemotherapy, and 64 matched-controls with no cancer, participated. Objective and subjective cognition, total sleep time, nap time, circadian activity rhythms (CAR), sleep quality, fatigue, and depression were measured pre-chemotherapy (Baseline), end of cycle 4 (Cycle-4), and one-year post-chemotherapy (1-Year). Results: WBC showed no change in objective cognitive measures from Baseline to Cycle-4 but significantly improved from both time points to 1-Year. Matched-controls showed an increase in test performance at all time points. WBC had significantly higher self-reported cognitive dysfunction at Cycle-4 and 1-Year compared to baseline and compared to matched-controls. Worse neuropsychological functioning was predicted by less robust CARs (i.e., inconsistent 24 h pattern), worse sleep quality, longer naps, and worse cognitive complaints. Worse subjective cognition was predicted by lower sleep quality and higher fatigue and depressed mood. Conclusion: Objective testing showed increases in performance scores from pre- and post-chemotherapy to one year later in WBC, but matched-controls showed an increase in test performance from baseline to Cycle-4 and from Cycle-4 to 1-Year, likely due to a practice effect. The fact that WBC showed no practice effects may reflect a form of learning deficit. Compared with the matched-controls, WBC reported significant worsened cognitive function. In WBC, worse objective and subjective cognitive functioning were predicted by worse sleep and sleep-related behaviors (naps and CAR). Interventions that target sleep, circadian rhythms, and fatigue may benefit cognitive function in WBC.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00520-021-06743-3

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 52

  1. Janelsins MC, Kesler SR, Ahles TA, Morrow GR (2014) Prevalence, mechanisms, and management of cancer-related cognitive impairment. International Review of Psychiatry 26(1):102–113. https://doi.org/10.3109/09540261.2013.864260 · DOI
  2. Wefel JS, Saleeba AK, Buzdar AU, Meyers CA (2010) Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer 116(14):3348–3356. https://doi.org/10.1002/cncr.25098 · DOI
  3. Joly F, Lange M, Dos Santos M, Vaz-Luis I (1896) Di Meglio A (2019) Long-term fatigue and cognitive disorders in breast cancer survivors. Cancers 11(12) · DOI
  4. van Dam FS, Boogerd W, Schagen SB, Muller MJ, Droogleever Fortuyn ME, Ev W, Rodenhuis S (1998) Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy. JNCI: Journal of the National Cancer Institute 90(3):210–218 · DOI
  5. Collins B, MacKenzie J, Tasca GA, Scherling C, Smith A (2013) Cognitive effects of chemotherapy in breast cancer patients: a dose–response study. Psycho-Oncology 22(7):1517–1527 · DOI
  6. Zunini RAL, Scherling C, Wallis N, Collins B, MacKenzie J, Bielajew C, Smith AM (2013) Differences in verbal memory retrieval in breast cancer chemotherapy patients compared to healthy controls: a prospective fMRI study. Brain Imaging and Behavior 7(4):460–477 · DOI
  7. Ahles TA, Saykin AJ, Furstenberg CT, Cole B, Mott LA, Skalla K, Whedon MB, Bivens S, Mitchell T, Greenberg ER (2002) Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol 20(2):485–493 · DOI
  8. El-Agamy SE, Abdel-Aziz AK, Esmat A, Azab SS (2019) Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain. Cancer chemotherapy and pharmacology:1-14 · DOI
  9. Wefel JS, Schagen SB (2012) Chemotherapy-related cognitive dysfunction. Curr Neurol Neurosci Rep 12(3):267–275. https://doi.org/10.1007/s11910-012-0264-9 · DOI
  10. Ganz PA, Kwan L, Castellon SA, Oppenheim A, Bower JE, Silverman DH, Cole SW, Irwin MR, Ancoli-Israel S, Belin TR (2013) Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance. JNCI: Journal of the National Cancer Institute 105(11):791–801 · DOI
  11. Schmidt ME, Wiskemann J, Steindorf K (2018) Quality of life, problems, and needs of disease-free breast cancer survivors 5 years after diagnosis. Qual Life Res 27(8):2077–2086 · DOI
  12. Feng Y, Wang YF, Zheng LJ, Shi Z, Huang W, Zhang LJ (2020) Network-level functional connectivity alterations in chemotherapy treated breast cancer patients: a longitudinal resting state functional MRI study. Cancer Imaging 20(1):1–13 · DOI
  13. Chen BT, Jin T, Patel SK, Ye N, Sun C-L, Ma H, Rockne RC, Root JC, Saykin AJ, Ahles TA (2018) Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer. Breast Cancer Res Treat 172(2):363–370 · DOI
  14. Koppelmans V, de Groot M, de Ruiter MB, Boogerd W, Seynaeve C, Vernooij MW, Niessen WJ, Schagen SB, Breteler MM (2014) Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy. Hum Brain Mapp 35(3):889–899 · DOI
  15. Rogers-Soeder TS, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Cauley JA, Ensrud KE, Paudel M, Barrett-Connor E, LeBlanc E (2018) Rest-activity rhythms and cognitive decline in older men: the osteoporotic fractures in men sleep study. J Am Geriatr Soc 66(11):2136–2143 · DOI
  16. Sultan A, Choudhary V, Parganiha A (2017) Worsening of rest-activity circadian rhythm and quality of life in female breast cancer patients along progression of chemotherapy cycles. Chronobiol Int 34(5):609–623. https://doi.org/10.1080/07420528.2017.1286501 · DOI
  17. Xu S, Thompson W, Ancoli-Israel S, Liu L, Palmer B, Natarajan L (2018) Cognition, quality-of-life, and symptom clusters in breast cancer: using Bayesian networks to elucidate complex relationships. Psychooncology 27(3):802–809. https://doi.org/10.1002/pon.4571 · DOI
  18. Carroll JE, Small BJ, Tometich DB, Zhai W, Zhou X, Luta G, Ahles TA, Saykin AJ, Nudelman KN, Clapp JD (2019) Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype. Cancer 125(24):4516–4524 · DOI
  19. Ancoli-Israel S, Liu L, Rissling M, Natarajan L, Neikrug AB, Palmer BW, Mills PJ, Parker BA, Sadler GR, Maglione J (2014) Sleep, fatigue, depression, and circadian activity rhythms in women with breast cancer before and after treatment: a 1-year longitudinal study. Support Care Cancer 22(9):2535–2545 · DOI
  20. Mormont M-C, Waterhouse J, Bleuzen P, Giacchetti S, Jami A, Bogdan A, Lellouch J, Misset J-L, Touitou Y, Lévi F (2000) Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status. Clin Cancer Res 6(8):3038–3045
  21. Innominato PF, Focan C, Gorlia T, Moreau T, Garufi C, Waterhouse J, Giacchetti S, Coudert B, Iacobelli S, Genet D (2009) Circadian rhythm in rest and activity: a biological correlate of quality of life and a predictor of survival in patients with metastatic colorectal cancer. Cancer Res 69(11):4700–4707 · DOI
  22. Cash E, Sephton SE, Chagpar AB, Spiegel D, Rebholz WN, Zimmaro LA, Tillie JM, Dhabhar FS (2015) Circadian disruption and biomarkers of tumor progression in breast cancer patients awaiting surgery. Brain Behav Immun 48:102–114. https://doi.org/10.1016/j.bbi.2015.02.017 · DOI
  23. Wefel JS, Vardy J, Ahles T, Schagen SB (2011) International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. The lancet oncology 12(7):703–708 · DOI
  24. Klemp JR, Myers JS, Fabian CJ, Kimler BF, Khan QJ, Sereika SM, Stanton AL (2018) Cognitive functioning and quality of life following chemotherapy in pre-and peri-menopausal women with breast cancer. Support Care Cancer 26(2):575–583 · DOI
  25. Liu L, Rissling M, Neikrug A, Fiorentino L, Natarajan L, Faierman M, Sadler GR, Dimsdale JE, Mills PJ, Parker BA, Ancoli-Israel S (2013) Fatigue and circadian activity rhythms in breast cancer patients before and after chemotherapy: a controlled study. Fatigue: Biomedicine, Health & Behavior 1(1-2):12–26. https://doi.org/10.1080/21641846.2012.741782 · DOI
  26. Liu L, Fiorentino L, Rissling M, Natarajan L, Parker BA, Dimsdale JE, Mills PJ, Sadler GR, Ancoli-Israel S (2013) Decreased health-related quality of life in women with breast cancer is associated with poor sleep. Behav Sleep Med 11(3):189–206 · DOI
  27. Mayo SJ, Lustberg M, Dhillon MH, Nakamura ZM, Allen DH, Von Ah D, Janelsins CM, Chan A, Olson K, Tan CJ, Toh YL, Oh J, Grech L, Cheung YT, Subbiah IM, Petranovic D, D’ Olimpio J, Gobbo M, Koeppen S et al (2021) Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC Neurological Complications Study Group. Support Care Cancer 29(6):2821–2840. https://doi.org/10.1007/s00520-020-05860-9 · DOI
  28. Rourke SB, Halman MH, Bassel C (1999) Neurocognitive complaints in HIV-infection and their relationship to depressive symptoms and neuropsychological functioning. J Clin Exp Neuropsychol 21(6):737–756 · DOI
  29. Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193–213 · DOI · Paper page
  30. Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak CP (2003) The role of actigraphy in the study of sleep and circadian rhythms. Sleep 26(3):342–392 · DOI · Paper page
  31. Marler MR, Gehrman P, Martin JL, Ancoli-Israel S (2006) The sigmoidally transformed cosine curve: a mathematical model for circadian rhythms with symmetric non-sinusoidal shapes. Stat Med 25(22):3893–3904 · DOI
  32. Savard J, Liu L, Natarajan L, Rissling MB, Neikrug AB, He F, Dimsdale JE, Mills PJ, Parker BA, Sadler GR, Ancoli-Israel S (2009) Breast cancer patients have progressively impaired sleep-wake activity rhythms during chemotherapy. Sleep 32(9):1155–1160. https://doi.org/10.1093/sleep/32.9.1155 · DOI
  33. Stein KD, Martin SC, Hann DM, Jacobsen PB (1998) A multidimensional measure of fatigue for use with cancer patients. Cancer Pract 6(3):143–152 · DOI
  34. Radloff LS (1977) The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1(3):385–401 · DOI · Paper page
  35. Wagner LI, Gray RJ, Sparano JA, Whelan TJ, Garcia SF, Yanez B, Tevaarwerk AJ, Carlos RC, Albain KS, Olson JA Jr, Goetz MP, Pritchard KI, Hayes DF, Geyer CE, Dees EC, McCaskill-Stevens WJ, Minasian LM, Sledge GW Jr, Cella D (2020) Patient-reported cognitive impairment among women with early breast cancer randomly assigned to endocrine therapy alone versus chemoendocrine therapy: results from TAILORx. J Clin Oncol 38(17):1875–1886. https://doi.org/10.1200/jco.19.01866 · DOI
  36. Ahles TA, Saykin AJ, McDonald BC, Li Y, Furstenberg CT, Hanscom BS, Mulrooney TJ, Schwartz GN, Kaufman PA (2010) Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol 28(29):4434–4440. https://doi.org/10.1200/JCO.2009.27.0827 · DOI
  37. Mandelblatt JS, Small BJ, Luta G, Hurria A, Jim H, McDonald BC, Graham D, Zhou X, Clapp J, Zhai W (2018) Cancer-related cognitive outcomes among older breast cancer survivors in the thinking and living with cancer study. J Clin Oncol 36(32):3211 · DOI
  38. Ono M, Ogilvie JM, Wilson JS, Green HJ, Chambers SK, Ownsworth T, Shum DH (2015) A meta-analysis of cognitive impairment and decline associated with adjuvant chemotherapy in women with breast cancer. Front Oncol 5:59 · DOI
  39. Lezak MD, Howieson DB, Bigle ED, Tranel D (2012) Neuropsychological assessment, 5th edn. Oxford University, New York
  40. Jutten RJ, Grandoit E, Foldi NS, Sikkes SA, Jones RN, Choi SE, Lamar ML, Louden DK, Rich J, Tommet D (2020) Lower practice effects as a marker of cognitive performance and dementia risk: a literature review. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 12(1):e12055
  41. Goldberg TE, Harvey PD, Wesnes KA, Snyder PJ, Schneider LS (2015) Practice effects due to serial cognitive assessment: implications for preclinical Alzheimer's disease randomized controlled trials. Alzheimers Dement (Amst) 1(1):103–111. https://doi.org/10.1016/j.dadm.2014.11.003 · DOI · Paper page
  42. Hutchinson AD, Hosking JR, Kichenadasse G, Mattiske JK, Wilson C (2012) Objective and subjective cognitive impairment following chemotherapy for cancer: a systematic review. Cancer Treat Rev 38(7):926–934 · DOI
  43. Bray VJ, Dhillon HM, Vardy JL (2018) Systematic review of self-reported cognitive function in cancer patients following chemotherapy treatment. J Cancer Surviv 12(4):537–559 · DOI
  44. Vearncombe KJ, Rolfe M, Wright M, Pachana NA, Andrew B, Beadle G (2009) Predictors of cognitive decline after chemotherapy in breast cancer patients. Journal of the International Neuropsychological Society: JINS 15(6):951 · DOI
  45. Walsh C, Tranah G, Stone K, Blackwell T, Redline S, Paudel M, Ancoli-Israel S, Kramer JH, Yaffe K (2013) P3–149: Circadian activity rhythm patterns in nondemented older women and cognitive function 5 years later. Alzheimers Dement 9:P608–P608 · DOI
  46. van Someren EJ, Hagebeuk EE, Lijzenga C, Scheltens P, de Rooij SE, Jonker C, Pot A-M, Mirmiran M, Swaab DF (1996) Circadian rest—activity rhythm disturbances in Alzheimer's disease. Biol Psychiatry 40(4):259–270 · DOI
  47. Banks S, Dinges DF (2007) Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med 3(5):519–528 · DOI · Paper page
  48. Chellappa SL, Morris CJ, Scheer F (2019) Effects of circadian misalignment on cognition in chronic shift workers. Sci Rep 9(1):699. https://doi.org/10.1038/s41598-018-36762-w · DOI
  49. Ancoli-Israel S, Rissling M, Neikrug A, Trofimenko V, Natarajan L, Parker BA, Lawton S, Desan P, Liu L (2012) Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer. Support Care Cancer 20(6):1211–1219 · DOI
  50. Neikrug AB, Rissling M, Trofimenko V, Liu L, Natarajan L, Lawton S, Parker BA, Ancoli-Israel S (2012) Bright light therapy protects women from circadian rhythm desynchronization during chemotherapy for breast cancer. Behav Sleep Med 10(3):202–216. https://doi.org/10.1080/15402002.2011.634940 · DOI
  51. Jeste N, Liu L, Rissling M, Trofimenko V, Natarajan L, Parker BA, Ancoli-Israel S (2013) Prevention of quality-of-life deterioration with light therapy is associated with changes in fatigue in women with breast cancer undergoing chemotherapy. Qual Life Res 22(6):1239–1244 · DOI
  52. Fiorentino L, McQuaid JR, Liu L, Natarajan L, He F, Cornejo M, Lawton S, Parker BA, Sadler GR, Ancoli-Israel S (2010) Individual cognitive behavioral therapy for insomnia in breast cancer survivors: a randomized controlled crossover pilot study. Nature and science of sleep 2:1

Cited by

See all 15

Metadata

Authors
Ancoli-Israel, S., Liu, L., Natarajan, L., Rissling, M., Neikrug, A. B., Youngstedt, S. D., Mills, P. J., Sadler, G. R., Dimsdale, J. E., Parker, B. A., & Palmer, B. W.
Venue
Supportive Care in Cancer
Publisher
Springer Science and Business Media LLC
Published
2021-12-26
Volume
30
Issue
4
Pages
3187-3200
ISSN
  • 0941-4355
  • 1433-7339
DOI
10.1007/s00520-021-06743-3
Cited by
15
References
1
Language
en
Licence
Funders
  • National Cancer Institute (CA112035)
  • National Institutes of Health (UL1RR031980)
  • U.S. Department of Veterans Affairs (CESAMH)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Reductions in sleep quality and circadian activity rhythmicity predict longitudinal changes in objective and subjective cognitive functioning in women treated for breast cancer. https://app.cochat.ai/papers/10.1007/s00520-021-06743-3
The paper
Ancoli-Israel, S., Liu, L., Natarajan, L., Rissling, M., Neikrug, A. B., Youngstedt, S. D., Mills, P. J., Sadler, G. R., Dimsdale, J. E., Parker, B. A., & Palmer, B. W. (2022). Reductions in sleep quality and circadian activity rhythmicity predict longitudinal changes in objective and subjective cognitive functioning in women treated for breast cancer. Supportive Care in Cancer. https://doi.org/10.1007/s00520-021-06743-3

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.