Immediate increase of portal pressure, reflecting sinusoidal shear stress, induced liver regeneration after partial hepatectomy
Abstract
The mechanisms whereby hepatocytes in the normal liver can be primed for replication following partial hepatectomy (PHx) are poorly understood. To determine whether "shear stress," which is induced by acute portal hypertension after PHx, is involved in liver regeneration, we studied liver regeneration in rats with splenic transposition (SPT) in which we can minimize the postoperative elevation of portal pressure. Rats underwent 70% PHx following splenic transposition or sham surgery and were killed at various time points to measure portal pressure and other factors. In the control groups, the portal pressure was significantly increased immediately after surgery, peaking at 48 h, and returning to near the preoperative levels by 168 h after PHx. In the SPT group, although portal pressure increased immediately, it decreased to the control levels 6 h after PHx and thereafter repeatedly increased. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels peaked at 24 and 6 h after PHx, respectively. Proliferative cell analysis was done using MIB-5 antibody, and there were no significant differences between the two groups. Furthermore, liver weight was restored in the same way in both groups. Taken together, the results suggest that an immediate increase in portal pressure is necessary for the initiation of liver regeneration.
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Increased portal pressure and blood flow induce shear stress on endothelial cells within the portal vascular network.
“The increased portal pressure and blood flow induce shear stress on endothelial cells within the portal vascular network[18].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [18]
Following 50%-70% partial hepatectomy, portal venous pressure increases significantly from a baseline of approximately 7-8 mmHg to 14-17 mmHg, reflecting increased sinusoidal shear stress that activates regenerative pathways.
“Experimental studies have demonstrated that following 50%–70% partial hepatectomy, the portal venous pressure (PVP) increases significantly—from a baseline of approximately 7–8 mmHg to 14–17 mmHg—reflecting increased sinusoidal shear stress that activates regenerative pathways.”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [18]
After 70% partial hepatectomy in rats, portal venous pressure rose from 8.4 ± 0.7 to 16.1 ± 1.3 mmHg, which correlated with hepatocyte proliferation observed within 24 hours postoperatively.
“It was reported that after 70% PHx in rats, PVP rose from 8.4 ± 0.7 to 16.1 ± 1.3 mmHg, which correlated with hepatocyte proliferation observed within 24 hours postoperatively[18].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [18]
Cites
Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944 · see citing works
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Mesenchymal stromal cells: promising treatment for liver cirrhosis
Yao, L., Hu, X., Dai, K., Yuan, M., Liu, P., Zhang, Q., & Jiang, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03001-z · Cited by 71 · see citing works
Liver regeneration after partial hepatectomy: Triggers and mechanisms
Korchilava, B., Khachidze, T., Megrelishvili, N., Svanadze, L., Kakabadze, M., Tsomaia, K., Jintcharadze, M., & Kordzaia, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i7.107378 · Cited by 21 · see citing works
- Authors
- Niiya, T., Murakami, M., Aoki, T., Murai, N., Shimizu, Y., & Kusano, M.
- Affiliations
- SHOWA Medical University (JP)
- Venue
- Journal of Hepato-Biliary-Pancreatic Surgery
- Published
- 1999-09-14
- Volume
- 6
- Issue
- 3
- Pages
- 275-280
- ISSN
- 0944-1166 (ISSN-L)
- 1436-0691
- OpenAlex
- W1968894777
- Cited by
- 96
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 7 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Hepato-Biliary-Pancreatic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, portal pressure, hepatocyte proliferation, TNF-α, interleukin-6
- MeSH terms
- Animals, Disease Models, Animal, Hepatectomy, Hypertension, Portal, Liver, Liver Regeneration, Male, Organ Size, Probability, Reference Values, Spleen, Stress, Mechanical, Tumor Necrosis Factor-alpha, Interleukin-6, Rats, Wistar, Rats
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