Cited by 291Helicobacter pylori-related gastroenterology studiesGastric Cancer Management and OutcomesGastrointestinal motility and disorders

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Helicobacter pylori and gastric carcinogenesis

Open access

Hatakeyama, Masanori·2009·Journal of Gastroenterology

DOI 10.1007/s00535-009-0014-1

Open this paper in CoChat — free account Open PDF

Abstract

Gastric carcinoma is the second leading cause of cancer-related deaths in the world, accounting for more than 700,000 deaths each year. Recent studies have revealed that infection with cagA-positive Helicobacter pylori plays an essential role in the development of gastric carcinoma. The cagA-encoded CagA protein is delivered into gastric epithelial cells via the bacterial type IV secretion system, where it undergoes tyrosine phosphorylation by Src and Abl kinases. Tyrosine-phosphorylated CagA then acquires the ability to interact with and deregulate SHP-2 phosphatase, a bona-fide oncoprotein, deregulation of which is involved in a variety of human malignancies. CagA also binds to and inhibits PAR1b/MARK2 polarity-regulating kinase to disrupt tight junctions and epithelial apical-basolateral polarity. These CagA activities may collectively contribute to the transformation of gastric epithelial cells. Indeed, transgenic expression of CagA in mice results in the development of gastrointestinal and hematological malignancies, indicating that CagA is the first bacterial oncoprotein that acts in mammalian cells. The oncogenic potential of CagA may be further potentiated in the presence of chronic inflammation, which aberrantly induces activation-induced cytidine deaminase (AID), a member of the DNA/RNA-editing enzyme family. Ectopically expressed AID may contribute to H. pylori-initiated gastric carcinogenesis by increasing the risk of likelihood of epithelial cells acquiring mutations in cancer-related genes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00535-009-0014-1

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Global cancer statistics
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Global Cancer Statistics, 2002
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.74 · Cited by 18,710
Helicobacter pylori Infection and the Development of Gastric Cancer
Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., & Schlemper, R. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa001999 · Cited by 4,492
Helicobacter pylori Infection and the Risk of Gastric Carcinoma
Parsonnet, J., FRIEDMAN, G. D., Vandersteen, D. P., Chang, Y., Vogelman∥, J. H., Orentreich∥, N., & Sibley, R. K. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110173251603 · Cited by 3,893
Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.
Correa, P. (1992) · PubMed · Cited by 3,149
cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
Censini, S., Lange, C., Xiang, Z., Crabtree, J. E., GHIARA, P., Borodovsky, M. Y., Rappuoli, R., & Covacci, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14648 · Cited by 1,872
Helicobacter pyloriInfection and Gastric Carcinoma among Japanese Americans in Hawaii
Nomura, A. M. Y., Stemmermann, G. N., Chyou, P., Kato, I., Perez-Perez, G. I., & Blaser, M. J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110173251604 · Cited by 1,761
E-cadherin germline mutations in familial gastric cancer
Guilford, P., Hopkins, J., Harraway, J. R., McLeod, M., McLeod, N., Harawira, P., Taite, H., Scoular, R., Miller, A. C., & Reeve, A. E. (1998) · Nature · doi:10.1038/32918 · Cited by 1,678
Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.
Blaser, M. J., Perez-Perez, G. I., Kleanthous, H., Cover, T. L., Peek, R. M., Chyou, P.-H., Stemmermann, G. N., & Nomura, A. M. Y. (1995) · PubMed · Cited by 1,608
Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China
Wong, B. C., Lam, S. K., Wong, W. M., Chen, J. S., Zheng, T., Feng, R. E., Lai, K. C., Hu, W. H. C., Yuen, S. T., Leung, S. Y., et al. (2004) · JAMA · doi:10.1001/jama.291.2.187 · Cited by 1,436

Show all 63 references

Sorted by citations

Pathobiology of Helicobacter pylori–Induced Gastric Cancer
Amieva, M. R., & Peek, R. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.09.004 · Cited by 907
Gastric Cancer
Correa, P. (2013) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2013.01.002 · Cited by 630
Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development
Watari, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i18.5461 · Cited by 321
Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity
Ansari, S., & Yamaoka, Y. (2019) · Toxins · doi:10.3390/toxins11110677 · Cited by 303
Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort Study
Kumar, S., Metz, D. C., Ellenberg, S. S., Kaplan, D. E., & Goldberg, D. S. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.019 · Cited by 291
Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258
Low Prevalence of Helicobacter pylori-negative Gastric Cancer among Japanese
Matsuo, T., Ito, M., Takata, S., Tanaka, S., Yoshihara, M., & Chayama, K. (2011) · Helicobacter · doi:10.1111/j.1523-5378.2011.00889.x · Cited by 249
A Global Overview of the Genetic and Functional Diversity in the Helicobacter pylori cag Pathogenicity Island
Olbermann, P., Josenhans, C., Moodley, Y., Uhr, M., Stamer, C., Vauterin, M., Suerbaum, S., Achtman, M., & Linz, B. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001069 · Cited by 235
Obesity and cancer pathogenesis
Berger, N. A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12416 · Cited by 241
The Long‐term Impact of Helicobacter pylori Eradication on Gastric Histology: a Systematic Review and Meta‐analysis
Rokkas, T., Pistiolas, D., Sechopoulos, P., Robotis, I., & Margantinis, G. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00563.x · Cited by 230
Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy
Chew, V., Toh, H. C., & Abastado, J. (2012) · Journal of Oncology · doi:10.1155/2012/608406 · Cited by 224
Gastric cancer review
Carcas, L. (2014) · Journal of Carcinogenesis · doi:10.4103/1477-3163.146506 · Cited by 206
Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets
Dhanisha, S. S., Guruvayoorappan, C., Drishya, S., & Abeesh, P. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.12.006 · Cited by 194
DNA Damage Response and Immune Defense: Links and Mechanisms
Nakad, R., & Schumacher, B. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00147 · Cited by 207
Chronic atrophic gastritis: Natural history, diagnosis and therapeutic management. A position paper by the Italian Society of Hospital Gastroenterologists and Digestive Endoscopists [AIGO], the Italian Society of Digestive Endoscopy [SIED], the Italian Society of Gastroenterology [SIGE], and the Italian Society of Internal Medicine [SIMI]
Lahner, E., Zagari, R. M., Zullo, A., Sabatino, A. D., Meggio, A., Cesaro, P., Lenti, M. V., Annibale, B., & Corazza, G. R. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.09.016 · Cited by 192
Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori : Genetic and Kinetic Characterization
Baker, L. M. S., Raudonikiene, A., Hoffman, P. S., & Poole, L. B. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1961-1973.2001 · Cited by 190
Meta‐analysis: esomeprazole or rabeprazole vs. first‐generation pump inhibitors in the treatment of H elicobacter pylori infection
McNicholl, A. G., Linares, P. M., Nyssen, O. P., Calvet, X., & Gisbert, J. P. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05211.x · Cited by 189
Helicobacter pylori Infection and Gastric Adenocarcinoma.
Correa, P., & Piazuelo, M. B. (2011) · PubMed · Cited by 185
Host pathogen interactions in Helicobacter pylori related gastric cancer
Chmiela, M., Karwowska, Z., Gonciarz, W., Allushi, B., & Stączek, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i9.1521 · Cited by 178
Patterns of gastric atrophy in intestinal type gastric carcinoma
El-Zimaity, H. M. T., Ota, H., Graham, D. Y., Akamatsu, T., & Katsuyama, T. (2002) · Cancer · doi:10.1002/cncr.10375 · Cited by 171
Virulence Factors of Helicobacter pylori: A Review
Röesler, B. M., Gonçalves, E. M. A. R., & Zeitune, J. M. R. (2014) · Clinical Medicine Insights Gastroenterology · doi:10.4137/cgast.s13760 · Cited by 163
Incomplete type of intestinal metaplasia has the highest risk to progress to gastric cancer: results of the Spanish follow‐up multicenter study
Gonzalez, C. A., Sanz‐Anquela, J. M., Companioni, O., Bonet, C., Berdasco, M., López, C., Mendoza, J., Martín‐Arranz, M. D., Rey, E., Poves, E., et al. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13249 · Cited by 140
CpG island hypermethylation in progression of esophageal and gastric cancer
Sato, F., & Meltzer, S. J. (2005) · Cancer · doi:10.1002/cncr.21657 · Cited by 143
Helicobacter pylori -induced inflammation and epigenetic changes during gastric carcinogenesis
Valenzuela, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i45.12742 · Cited by 135
Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway
Maeda, M., Moro, H., & Ushijima, T. (2016) · Gastric Cancer · doi:10.1007/s10120-016-0650-0 · Cited by 131
Glycomic and Glycoproteomic Analysis of Serum from Patients with Stomach Cancer Reveals Potential Markers Arising from Host Defense Response Mechanisms
Bones, J., Byrne, J. C., O'Donoghue, N. M., McManus, C. A., Scaife, C., Boissin, H., Năstase, A., & Rudd, P. M. (2010) · Journal of Proteome Research · doi:10.1021/pr101036b · Cited by 130
Helicobacter pylori infection: host immune response, implications on gene expression and microRNAs.
Cadamuro, A., Rossi, A. F. T., Maniezzo, N., & Silva, A. E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i6.1424 · Cited by 119
Molecular Pathways: Involvement of Helicobacter pylori–Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers
Ushijima, T., & Hattori, N. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2011 · Cited by 130
Helicobacter pylori research: historical insights and future directions
Fock, K. M., Graham, D. Y., & Malfertheiner, P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.96 · Cited by 123
Regulation of Gastric Carcinogenesis by Inflammatory Cytokines
Bockerstett, K. A., & DiPaolo, R. J. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.03.005 · Cited by 126
Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection
Park, S.-Y., Yoo, E. J., Cho, N., Kim, N., & Kang, G. H. (2009) · The Journal of Pathology · doi:10.1002/path.2596 · Cited by 118
A Review of the Genomics of Gastric Cancer
Hamilton, J. P., & Meltzer, S. J. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.01.019 · Cited by 116
Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence
Gonzalez, C. A., Sanz‐Anquela, J. M., Gisbert, J. P., & Correa, P. (2012) · International Journal of Cancer · doi:10.1002/ijc.28003 · Cited by 116
Gastritis and Carditis
Owen, D. A. (2003) · Modern Pathology · doi:10.1097/01.mp.0000062995.72390.14 · Cited by 114
Gastric Cancer in the Era of Precision Medicine
Liu, X., & Meltzer, S. J. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.02.003 · Cited by 114
The regulatory roles of phosphatases in cancer
Stebbing, J., Lit, L. C., Zhang, H., Darrington, R. S., Melaiu, O., Rudraraju, B., & Giamas, G. (2013) · Oncogene · doi:10.1038/onc.2013.80 · Cited by 113
miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer
Jiang, B., Li, Z., Zhang, W., Wang, H., Zhi, X., Feng, J., Chen, Z., Zhu, Y., Yang, L., Xu, H., et al. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0851-9 · Cited by 111
Gastric Cancer: An Infectious Disease
Piazuelo, M. B., Epplein, M., & Correa, P. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.010 · Cited by 109
The Role of Serum Pepsinogen and Gastrin Test for the Detection of Gastric Cancer in Korea
Kang, J. M., Kim, N., Yoo, J. Y., Park, Y. S., Lee, D. H., Kim, H. Y., Lee, H. S., Choe, G., Kim, J. S., Jung, H. C., et al. (2008) · Helicobacter · doi:10.1111/j.1523-5378.2008.00592.x · Cited by 104
Bile Acid Promotes Intestinal Metaplasia and Gastric Carcinogenesis
Tatsugami, M., Ito, M., Tanaka, S., Yoshihara, M., Matsui, H., Haruma, K., & Chayama, K. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0730 · Cited by 102
Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation
Tsang, Y. H., Lamb, A., Romero–Gallo, J., Huang, B., Ito, K., Peek, R. M., Ito, Y., & Chen, L. F. (2010) · Oncogene · doi:10.1038/onc.2010.304 · Cited by 100
A Comprehensive Sequence and Disease Correlation Analyses for the C-Terminal Region of CagA Protein of Helicobacter pylori
Xia, Y., Yamaoka, Y., Zhu, Q., Matha, I., & Gao, X. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007736 · Cited by 102
CagA-mediated pathogenesis of Helicobacter pylori
Tohidpour, A. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.01.005 · Cited by 100
The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa
Molina‐Castro, S., Tiffon, C., Giraud, J., Bœuf, H., Sifré, E., Giese, A., Belleannée, G., Lehours, P., Bessède, E., Mégraud, F., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.10.007 · Cited by 94
Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification
Wang, Y., Chu, F., Lin, J., Li, Y., Johnson, N. L., Zhang, J., Gai, C., Su, Z., Cheng, H.-J., Wang, L., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114399 · Cited by 95
Helicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cells
Choi, Y. J., Kim, N., Chang, H. K., Lee, H. S., Park, S. M., Park, J. H., Shin, C. M., Kim, J. M., Kim, J. S., Lee, D. H., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv022 · Cited by 93
Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease
Bridge, D. R., & Merrell, D. S. (2013) · Gut Microbes · doi:10.4161/gmic.23797 · Cited by 92
Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer
Nishikawa, J., Iizasa, H., Yoshiyama, H., Shimokuri, K., Kobayashi, Y. O., Sasaki, S., Nakamura, M., Yanai, H., Sakai, K., Suehiro, Y., et al. (2018) · Cancers · doi:10.3390/cancers10060167 · Cited by 88
Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses
Asano, N., Imatani, A., Watanabe, T., Fushiya, J., Kondo, Y., Jin, X., Ara, N., Uno, K., Iijima, K., Koike, T., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2272 · Cited by 86
Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review
Ito, M., Takata, S., Tatsugami, M., Wada, Y., Imagawa, S., Matsumoto, Y., Takamura, A., Kitamura, S., Matsuo, T., Tanaka, S., et al. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0036-8 · Cited by 77
Helicobacter pylori cholesteryl glucosides interfere with host membrane phase and affect type IV secretion system function during infection in AGS cells
Wang, H., Cheng, W., Cheng, H., Lai, C., & Wang, W. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07910.x · Cited by 73
Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis
Bockerstett, K. A., Osaki, L. H., Petersen, C. P., Cai, C. W., Wong, C. F., Nguyen, T.-L. M., Ford, E. L., Hoft, D. F., Mills, J. C., Goldenring, J. R., et al. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.12.012 · Cited by 72
Deregulation of β‐catenin signal by Helicobacter pylori CagA requires the CagA‐multimerization sequence
Kurashima, Y., Murata‐Kamiya, N., Kikuchi, K., Higashi, H., Azuma, T., Kondo, S., & Hatakeyama, M. (2007) · International Journal of Cancer · doi:10.1002/ijc.23190 · Cited by 72
Self-citation
Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma
Lee, B. M., Jang, J. J., & Kim, H. S. (1998) · Cancer Letters · doi:10.1016/s0304-3835(97)00520-x · Cited by 69
Evolutionary History of the Helicobacter pylori Genome: Implications for Gastric Carcinogenesis
Correa, P., & Piazuelo, M. B. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.1.21 · Cited by 69
Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8
Farnbacher, M., Jahns, T., Willrodt, D., Daniel, R., Haas, R., Goesmann, A., Kurtz, S., & Rieder, G. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-335 · Cited by 68
Microbiota in the stomach and application of probiotics to gastroduodenal diseases
Koga, Y. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i47.6702 · Cited by 67
Dysfunctional Gastric Emptying With Down-regulation of Muscle-Specific MicroRNAs in Helicobacter pylori-Infected Mice
Saito, Y., Suzuki, H., Tsugawa, H., Suzuki, S., Matsuzaki, J., Hirata, K., & Hibi∥, T. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.044 · Cited by 66
Helicobacter pylori vacA s1m1 genotype but not cagA or babA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico
Román-Román, A., Martínez-Carrillo, D. N., Atrisco-Morales, J., Azúcar-Heziquio, J. C., Cuevas-Caballero, A. S., Castañón‐Sánchez, C. A., Reyes-Ríos, R., Betancourt-Linares, R., Reyes-Navarrete, S., Carmen, I. C.-D., et al. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0167-z · Cited by 62
Helicobacter pylori in Childhood: New Insights Into the Immunopathogenesis of Gastric Disease and Implications for Managing Infection in Children
Ernst, P. B., & Gold, B. D. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199905000-00005 · Cited by 60
Characteristics of gastric cancer according to H elicobacter pylori infection status
Kwak, H. A., Choi, I. J., Cho, S., Lee, J. Y., Kim, C. G., Kook, M., Ryu, K. W., & Kim, Y. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12605 · Cited by 58
Helicobacter pylori infection and lung cancer: a review of an emerging hypothesis
Deng, B., Li, Y., Zhang, Y., Bai, L., & Yang, P. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt114 · Cited by 57
Multiple Infections and Cancer: Implications in Epidemiology
Vedham, V., Divi, R. L., Starks, V. L., & Verma, M. (2013) · Technology in Cancer Research & Treatment · doi:10.7785/tcrt.2012.500366 · Cited by 56
Biopsy site for detecting Helicobacter pylori infection in patients with gastric cancer
Kim, C. G., Choi, I. J., Lee, J. Y., Cho, S., Nam, B., Kook, M., Hong, E. K., & Kim, Y. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05679.x · Cited by 55
Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer
Epplein, M., Pawlita, M., Michel, A., Peek, R. M., Cai, Q., & Blot, W. J. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0702 · Cited by 53
Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection
Rivas-Ortiz, C. I., López‐Vidal, Y., Arredondo‐Hernández, R., & Castillo-Rojas, G. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00047 · Cited by 53
Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation
Busada, J. T., Ramamoorthy, S., Cain, D. W., Xu, X., Cook, D. N., & Cidlowski, J. A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123233 · Cited by 53
Autoimmune Gastritis and Gastric Microbiota
Conti, L., Annibale, B., & Lahner, E. (2020) · Microorganisms · doi:10.3390/microorganisms8111827 · Cited by 53
Unifying Themes in Microbial Associations with Animal and Plant Hosts Described Using the Gene Ontology
Torto-Alalibo, T. A., Collmer, C. W., Giglio, M. G., Lindeberg, M., Meng, S., Chibucos, M. C., Tseng, T., Lomax, J., Biehl, B. S., Ireland, A., et al. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-10 · Cited by 53
High-Salt Diet Exacerbates H. pylori Infection and Increases Gastric Cancer Risks
Balendra, V., Amoroso, C., Galassi, B., Esposto, J., Bareggi, C., Luu, J. H., Scaramella, L., & Ghidini, M. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13091325 · Cited by 51
Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer
Hou, R., Cao, B., Zhong-dong, C., Li, Y., Ning, T., Xu, C., Xu, C., & Chen, Z. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9705-1 · Cited by 51
Role of Helicobacter pylori in Gastric Carcinogenesis: The Origin of Gastric Cancers and Heterotopic Proliferative Glands in Mongolian Gerbils
Tatematsu, M., Tsukamoto, T., & Mizoshita, T. (2005) · Helicobacter · doi:10.1111/j.1523-5378.2005.00305.x · Cited by 51
Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations
Katoh, H., & Ishikawa, S. (2021) · Journal of Human Genetics · doi:10.1038/s10038-021-00960-8 · Cited by 50
Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages
Du, S.-Y., Wang, H., Cheng, H., Chen, S.-D., Wang, L. H.-C., & Wang, W. (2014) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2014.05.011 · Cited by 49
Helicobacter pyloriand the molecular pathogenesis of intestinal-type gastric carcinoma
Hanada, K., & Graham, D. Y. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2014.911092 · Cited by 49
Development of gastric adenocarcinoma in Mongolian gerbils after long‐term infection with Helicobacter pylori
Zheng, Q., Chen, X. Y., SHI, Y., & Shu Dong, X. I. A. O. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03469.x · Cited by 49
Characterization of Streptococcus salivarius as New Probiotics Derived From Human Breast Milk and Their Potential on Proliferative Inhibition of Liver and Breast Cancer Cells and Antioxidant Activity
Srikham, K., Daengprok, W., Niamsup, P., & Thirabunyanon, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.797445 · Cited by 51
Effect of Eradication of Helicobacter pylori on the Histology and Cellular Phenotype of Gastric Intestinal Metaplasia
Watari, J., Das, K. K., Amenta, P. S., Tanabe, H., Tanaka, A., Geng, X., Lin, J. J., Kohgo, Y., & Das, K. M. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.12.044 · Cited by 48
Reactive Nitrogen Species Mediate DNA Damage in Helicobacter pylori‐Infected Gastric Mucosa
Katsurahara, M., Kobayashi, Y., Iwasa, M., Ma, N., Inoue, H., Fujita, N., Tanaka, K., Horiki, N., Gabazza, E. C., & Takei, Y. (2009) · Helicobacter · doi:10.1111/j.1523-5378.2009.00719.x · Cited by 45
Clinicopathologic characteristics and prognosis of synchronous multifocal gastric carcinomas
Otsuji, E., Kuriu, Y., Ichikawa, D., Okamoto, K. K., Hagiwara, A., & Yamagishi, H. (2005) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2004.03.013 · Cited by 45
RETRACTED: Increased Risk of Stomach and Esophageal Malignancies in People With AIDS
Persson, E. C., Shiels, M. S., Dawsey, S. M., Bhatia, K. G., Anderson, L. A., & Engels, E. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.013 · Cited by 44
Retracted
Detailed clinicopathological characteristics and possible lymphomagenesis of type II intestinal enteropathy-associated T-cell lymphoma in Japan
Kikuma, K., Yamada, K., Nakamura, S., Ogami, A., Nimura, S., Hirahashi, M., Yonemasu, H., Urabe, S., Naito, S., Matsuki, Y., et al. (2014) · Human Pathology · doi:10.1016/j.humpath.2013.10.038 · Cited by 43
The role of Th cell subsets in the control of Helicobacter infections and in T cell-driven gastric immunopathology
Hitzler, I., Kohler, E., Engler, D. B., Sayi‐Yazgan, A., & Mueller, A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00142 · Cited by 42
Diversity ofHelicobacter pylorigenotypes in Iranian patients with different gastroduodenal disorders
Vaziri, F. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i34.5685 · Cited by 42
Deconstructing host-pathogen interactions inDrosophila
Bier, E., & Guichard, A. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.000406 · Cited by 42
The changing trends of the incidence of gastric cancer after Helicobacter pylori eradication in Shandong area
Zhou, L., San Ren, L. I. N., Ding, S. G., HUANG, X. B., ZHANG, L., Ling Mei, M. E. N. G., Rong Li, C. U. I., & Jin, Z. H. U. (2005) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2005.00204.x · Cited by 42
Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin
Liu, Y. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i21.2674 · Cited by 41
The EPIYA-ABCC motif pattern in CagA of Helicobacter pyloriis associated with peptic ulcer and gastric cancer in Mexican population
Beltrán‐Anaya, F. O., Poblete, T. M., Román-Román, A., Reyes-Navarrete, S., Sampedro-Reyes, J. D., Peralta-Zaragoza, Ó., Rodríguez, M. Á., Moral-Hernández, Ó. D., Illades‐Aguiar, B., & Fernández‐Tilapa, G. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0223-9 · Cited by 40
Helicobacter pylori bacteria alter the p53 stress response via Erk-HDM2 pathway
Bhardwaj, V., Noto, J. M., Wei, J., Andl, C. D., El-Rifai, W. M., Peek, R. M., & Zaika, A. I. (2015) · Oncotarget · doi:10.18632/oncotarget.2828 · Cited by 40
Inhibition of ADP Ribosylation Prevents and Cures Helicobacter -Induced Gastric Preneoplasia
Toller, I. M., Altmeyer, M., Kohler, E., Hottiger, M. O., & Mueller, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0528 · Cited by 39
Clinical relevance of cagL gene and virulence genotypes with disease outcomes in a Helicobacter pylori infected population from Iran
Yadegar, A., Mobarez, A. M., Alebouyeh, M., Mirzaei, T., Kwok, T., & Zali, M. R. (2014) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-014-1673-5 · Cited by 38
Genetic diversity and amino acid sequence polymorphism in Helicobacter pylori CagL hypervariable motif and its association with virulence markers and gastroduodenal diseases
Yadegar, A., Mobarez, A. M., & Zali, M. R. (2019) · Cancer Medicine · doi:10.1002/cam4.1941 · Cited by 38
Clinicopathologic Implications of Genetic Instability in Intestinal-Type Gastric Cancer and Intestinal Metaplasia as a Precancerous Lesion
Zaky, A. H., Watari, J., Tanabe, H., Sato, R., Moriichi, K., Tanaka, A., Maemoto, A., Fujiya, M., Ashida, T., & Kohgo, Y. (2008) · American Journal of Clinical Pathology · doi:10.1309/dflelpgpnv5lk6b1 · Cited by 38
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3‐Lgr4 axis
Wizenty, J., Müllerke, S., Kolesnichenko, M., Heuberger, J., Lin, M., Fischer, A., Mollenkopf, H., Berger, H., Tacke, F., & Sigal, M. J. (2022) · The EMBO Journal · doi:10.15252/embj.2021109996 · Cited by 37
Status of kinases in Epstein-Barr virus and Helicobacter pylori Coinfection in gastric Cancer cells
Sonkar, C., Verma, T., Chatterji, D., Jain, A. K., & Jha, H. C. (2020) · BMC Cancer · doi:10.1186/s12885-020-07377-0 · Cited by 37
Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis
Raza, Y., Khan, A., Farooqui, A., Mubarak, M., Facista, A., Akhtar, S. S., Khan, S., Kazi, J. I., Bernstein, C., & Kazmi, S. U. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-014-9762-1 · Cited by 37
MGMTandMLH1methylation inHelicobacter pylori-infected children and adults
Alvarez, M. C. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i20.3043 · Cited by 36
Chronic CagA‐positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell‐like properties in gastric mucosal epithelial cells
Li, L., Wei, H., Yi, J., Xie, B., Chen, J., Zhou, C., Wang, L., & Yang, Y. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29031 · Cited by 36
Effect of polymorphisms in the 3′ untranslated region (3′‐UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan
Tahara, T., Shibata, T., Nakamura, M., Yamashita, H., Yoshioka, D., Hirata, I., & Arisawa, T. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20554 · Cited by 36
Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase
Shibayama, K., Takeuchi, H., Wachino, J., Mori, S., & Arakawa, Y. (2011) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2011.00333.x · Cited by 35

Authors: Hatakeyama, M.
Affiliations: Hokkaido University (JP)
Corresponding author: Hatakeyama, Masanori
ORCID: Hatakeyama, Masanori
Venue: Journal of Gastroenterology
Publisher: Springer Science and Business Media LLC
Published: 2009-03-07
Volume: 44
Issue: 4
Pages: 239-248
ISSN: 0944-1174 (ISSN-L)
1435-5922
DOI: 10.1007/s00535-009-0014-1
OpenAlex: W2147579496
Cited by: 291
References: 63
Citations by year: 2026: 2 · 2025: 7 · 2024: 13 · 2023: 6 · 2022: 11 · 2021: 11 · 2020: 11 · 2019: 17 · 2018: 8 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 22 · 2013: 30 · 2012: 16
FWCI: 4.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science
Topics: Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Helicobacter pylori, gastric carcinogenesis, gastric cancer, CagA, type IV secretion system, tyrosine phosphorylation, Src kinase, c-Abl, tight junctions, epithelial polarity, chronic inflammation, activation-induced cytidine deaminase, transgenic mouse model, hematologic malignancies
MeSH terms: AICDA (Activation-Induced Cytidine Deaminase), Animals, Antigens, Bacterial, Bacterial Proteins, Cytidine Deaminase, Epithelial Cells, Humans, Mice, Transgenic, Mutation, Phosphorylation, Stomach Neoplasms, Helicobacter pylori, Helicobacter Infections, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Helicobacter pylori and gastric carcinogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks