The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Effect of intraoperative application of ketamine on postoperative depressed mood in patients undergoing elective orthopedic surgery
Abstract
Purpose A depressed mood frequently occurs in perioperative patients, negatively impacting patient recovery. Recent studies suggested that ketamine has a rapid, obvious, and persistent antidepressant effect. The purpose of this study was to investigate the impact of intraoperative application of ketamine on postoperative depressive mood in patients undergoing elective orthopedic surgery. Methods This was a randomized, double-blind, controlled study. A total of 120 patients (ASA grade I-II) undergoing elective orthopedic surgery were divided randomly into a ketamine group (group K) and a control group (group C). In the K group, 0.5 mg/kg (0.05 ml/kg) ketamine was given at induction of anesthesia, followed by 0.25 mg/kg/h (0.025 ml/kg/h) continuous infusion for 30 min. In the C group, 0.05 ml/kg 0.9 % saline was used at induction of anesthesia, followed by 0.025 ml/kg/h continuous infusion of saline for 30 min. PHQ-9 score was recorded preoperatively (1 day before surgery) and postoperatively (on day 1 and day 5 following surgery). Blood at these time points was drawn for serum brain-derived neurotrophic factor (BDNF) level analysis. Intraoperative blood loss, surgery time, postoperative visual analog scale pain scores and perioperative complications were also recorded. Results There were no differences in age, sex, surgery time, blood loss, and preoperative PHQ-9 scores between the two groups (P > 0.05). There were no differences in PHQ-9 scores preoperatively and postoperatively for the C group (P > 0.05); however, the PHQ-9 postoperative scores were lower than the preoperative PHQ-9 scores in the K group (P < 0.01). Postoperative PHQ-9 scores of K group were lower than those of C group (P < 0.05). There were no differences in serum BDNF levels in C group pre- to postoperatively (P > 0.05). Compared with the preoperative BDNF levels of K group, postoperative BDNF levels in K group increased significantly (P < 0.01). An inverse correlation between PHQ-9 score and serum BDNF level was shown. Conclusion Intraoperative application of ketamine was associated with improved scores for depressed mood and increased serum BDNF levels in patients undergoing elective orthopedic surgery.
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“several studies have demonstrated that intraoperative ketamine administration can improve postoperative mood even though the patients were unconscious at the time of administration”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [230]
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Cites
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
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Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
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Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
aan het Rot, M., Collins, K. A., Murrough, J. W., Perez, A. M., Reich, D. L., Charney, D. S., & Mathew, S. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.038 · Cited by 690
Remifentanil-induced Postoperative Hyperalgesia and Its Prevention with Small-dose Ketamine
Joly, V., Richebe, P., Guignard, B., Fletcher, D., Maurette, P., Sessler, D. I., & Chauvin, M. (2005) · Anesthesiology · doi:10.1097/00000542-200507000-00022 · Cited by 618
Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.027 · Cited by 454
Ketamine for Depression: Where Do We Go from Here?
aan het Rot, M., Zarate, C. A., Charney, D. S., & Mathew, S. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.003 · Cited by 418
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Perioperative intravenous ketamine for acute postoperative pain in adults
Brinck, E., Tiippana, E., Heesen, M., Bell, R. F., Straube, S., Moore, R. A., & Kontinen, V. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012033.pub4 · Cited by 373
Cited by
Perioperative intravenous ketamine for acute postoperative pain in adults
Brinck, E., Tiippana, E., Heesen, M., Bell, R. F., Straube, S., Moore, R. A., & Kontinen, V. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012033.pub4 · Cited by 373
The subjective effects of psychedelics may not be necessary for their enduring therapeutic effects
Olson, D. E. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00192 · Cited by 329
Psychedelics and Other Psychoplastogens for Treating Mental Illness.
Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166
Effect of Pretreatment of S-Ketamine On Postoperative Depression for Breast Cancer Patients
Liu, P., Li, P., Li, Q., Yan, H., Shi, X., Liu, C., Zhang, Y., & Peng, S. (2021) · Journal of Investigative Surgery · doi:10.1080/08941939.2019.1710626 · Cited by 103
Metadata
- Authors
- Jiang, M., Wang, M.-H., Wang, X.-B., Liu, L., Wu, J.-L., Yang, X.-L., Liu, X.-R., & Zhang, C.-X.
- Affiliations
- First Affiliated Hospital of Sichuan Medical University (CN)
- Rush University (US)
- Venue
- Journal of Anesthesia
- Published
- 2015-11-18
- Volume
- 30
- Issue
- 2
- Pages
- 232-237
- ISSN
- 0913-8668 (ISSN-L)
- 1438-8359
- OpenAlex
- W2200075077
- Cited by
- 57
- References
- 41
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 11 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 1 · 2018: 6 · 2017: 1 · 2016: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Anesthesia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the National Natural Science Foundation of China (81271478)
- International Cooperation, Department of Science &Technology of Sichuan Province (2011HH0031)
- Education Department of Sichuan Province (CN) (14106)
- Innovative Team, Department of Education of Sichuan Province (14TD0018)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- ketamine, postoperative depression, depressive mood, elective orthopaedic surgery, brain-derived neurotrophic factor, antidepressant effects, PHQ-9
- MeSH terms
- Adult, Double-Blind Method, Female, Humans, Ketamine, Male, Pain, Postoperative, Postoperative Pain, Postoperative Period, Elective Surgical Procedures, Brain-Derived Neurotrophic Factor, Orthopedic Procedures
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- Jiang, M., Wang, M.-H., Wang, X.-B., Liu, L., Wu, J.-L., Yang, X.-L., Liu, X.-R., & Zhang, C.-X. (2016). Effect of intraoperative application of ketamine on postoperative depressed mood in patients undergoing elective orthopedic surgery. Journal of Anesthesia. https://doi.org/10.1007/s00540-015-2096-7
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