Cited by 110Chronic Kidney Disease and DiabetesRenal Diseases and GlomerulopathiesAdipokines, Inflammation, and Metabolic Diseases

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Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats

Moriwaki, Yuji, Inokuchi, Taku, Yamamoto, Asako, Ka, Tsuneyoshi, Tsutsumi, Zenta, Takahashi, Sumio, Yamamoto, Tetsuya·2007·Acta Diabetologica

DOI 10.1007/s00592-007-0007-6

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Abstract

The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar rats, 8-week-old, were categorized into four groups, which were the control (n = 9), diabetes (n = 9), infliximab-treated diabetes (n = 10), and FR167653-treated diabetes (n = 9) groups. Diabetes was induced by intraperitoneal injection of STZ (40 mg/kg). Thereafter, infliximab was injected intraperitoneally once a month (5.5 mg/kg) and FR167653 was administered orally by mixing with the rat chow (0.08%). The effects of infliximab and FR167653 on urinary albumin excretion were observed for 12 weeks. Body weight, blood sugar, 24-h urinary TNF-alpha, and 24-h urinary albumin/creatinine ratio (Ualb/Ucr) levels were determined at 1, 4, 8, and 12 weeks after the STZ-injection. Treatment of rats with STZ caused a significant loss of body weight, as well as polyuria and hyperglycemia within 1 week, while the urinary excretions of albumin and TNF-alpha were increased. Neither infliximab nor FR167653 affected body weight or blood sugar levels, whereas both decreased urinary albumin excretion, together with a modest decrease in the urinary excretion of TNF-alpha. These results suggest a role of TNF-alpha in the pathogenesis of diabetic nephropathy and show that TNF-alpha inhibition is a potential therapeutic strategy.

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Authors: Moriwaki, Y., Inokuchi, T., Yamamoto, A., Ka, T., Tsutsumi, Z., Takahashi, S., & Yamamoto, T.
Affiliations: Hyogo Medical University (JP)
Corresponding author: Moriwaki, Yuji
ORCID: Yamamoto, Tetsuya
Venue: Acta Diabetologica
Publisher: Springer Science and Business Media LLC
Published: 2007-09-01
Volume: 44
Issue: 4
Pages: 215-218
ISSN: 0940-5429 (ISSN-L)
1432-5233
DOI: 10.1007/s00592-007-0007-6
OpenAlex: W2035793960
Cited by: 110
References: 19
Citations by year: 2025: 4 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 5 · 2012: 15
FWCI: 3.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Acta Diabetologica (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: anti-TNF therapy, urinary albumin excretion, diabetic nephropathy, infliximab, FR167653, streptozotocin-induced diabetes, TNF-α, albuminuria
MeSH terms: Infliximab, Albuminuria, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, Diabetes Mellitus, Experimental, Male, Pyrazoles, Pyridines, Tumor Necrosis Factor-alpha, Rats, Wistar, Rats

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Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats

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