Association between ADHD and smoking in adolescence: shared genetic, environmental and psychopathological factors
Abstract
The present study aimed to examine the extent to which the co-occurrence of ADHD and smoking in adolescents could be attributed to common genetic, environmental and psychopathological factors. Data are from an ongoing prospective study of the outcome of early risk factors. At age 15 years, 305 adolescents completed self-report questionnaires measuring tobacco consumption and deviant peer affiliations. Lifetime psychiatric diagnoses were obtained using standardized interviews. DNA was genotyped for the dopamine D4 receptor (DRD4) gene exon III polymorphism. Adolescents with a lifetime diagnosis of ADHD displayed significantly higher smoking activity than non-ADHD controls. A major component of this association could be accounted for by deviant peer affiliations and the comorbidity with oppositional-defiant and conduct disorder, while a minor part was attributable to DRD4 in males but not in females. These findings suggest that the association of ADHD with smoking relies on risk factors shared by the two behaviors.
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The DAT1 10R-6R allele has been found to moderate the effects of early institutional deprivation and psychosocial adversity on ADHD risk.
“Specifically, the DAT1 10R-6R allele has been found to moderate the effects of early institutional deprivation (Stevens et al., 2009) and psychosocial adversity (Laucht et al., 2007) on ADHD risk.”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Laucht et al., 2007
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References 38 · Cited by 41
- Authors
- Laucht, M., Hohm, E., Esser, G., Schmidt, M. H., & Becker, K.
- Affiliations
- Central Institute of Mental Health (DE)
- University of Potsdam (DE)
- ORCID
- Venue
- Journal of Neural Transmission
- Published
- 2007-04-04
- Volume
- 114
- Issue
- 8
- Pages
- 1097-1104
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W1973741553
- Cited by
- 41
- References
- 38
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 7
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- publish.UP (University of Potsdam) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- attention deficit hyperactivity disorder, adolescent smoking, tobacco use, deviant peer affiliation, oppositional defiant disorder, conduct disorder, dopamine D4 receptor, genetic risk factors, psychopathology, sex differences
- MeSH terms
- Adolescent, Adult, Aging, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Brain Chemistry, Child, Child Behavior Disorders, Child, Preschool, Dopamine, Environment, Female, Genetic Markers, Genetic Testing, Humans, Infant, Longitudinal Studies, Male, Polymorphism, Genetic, Prospective Studies, Sex Characteristics, Smoking, Comorbidity, Genetic Predisposition to Disease, Receptors, Dopamine D4
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