On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079
Abstract
The role of the ATP-gated receptor, P2X(7), has been evaluated in the unilateral 6-OHDA rat model of Parkinson's disease using the P2X(7) competitive antagonist A-438079. Nigral P2X(7) immunoreactivity was mainly located in microglia but also in astroglia. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. However, this was not associated with a reduction of DA cell loss. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease and warrants further future investigation.
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An antagonist for P2X7 significantly prevented depletion of striatal dopaminergic neurons in a 6-OHDA rat model.
“An antagonist for P2X7 significantly prevented the depletion of striatal dopaminergic neurons.384”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [384]
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References 23 · Cited by 97
- Authors
- Marcellino, D., Suárez-Boomgaard, D., Sánchez-Reina, M. D., Aguirre, J. A., Yoshitake, T., Yoshitake, S., Hagman, B., Kehr, J., Agnati, L. F., Fuxe, K., & Rivera, A.
- Affiliations
- Karolinska Institutet (SE)
- Universidad de Málaga (ES)
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Marcellino, Daniel
- Venue
- Journal of Neural Transmission
- Published
- 2010-04-13
- Volume
- 117
- Issue
- 6
- Pages
- 681-687
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2094021064
- Cited by
- 97
- References
- 23
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 7 · 2012: 6
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Parkinsonfonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- P2X7 receptor, Parkinson's disease, 6-hydroxydopamine, striatal dopamine depletion, astrocytes, neuroprotection
- MeSH terms
- Analysis of Variance, Animals, Brain, Cell Count, Chromatography, High Pressure Liquid, Disease Models, Animal, Dopamine, Glial Fibrillary Acidic Protein, Homovanillic Acid, Male, Nerve Degeneration, Neural Pathways, Parkinson Disease, Pyridines, Tetrazoles, 3,4-Dihydroxyphenylacetic Acid, Oxidopamine, Rats, Sprague-Dawley, Receptors, Purinergic P2, Adrenergic Agents, Statistics, Nonparametric, Rats, Receptors, Purinergic P2X7, Purinergic P2 Receptor Antagonists
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