Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats
Abstract
Methylphenidate (MPH) is a stimulatory agent in brain with unknown long-term consequences. In this study, MPH-induced neurodegeneration in adult rat brain was assessed. Rats were acutely treated with different doses of MPH. Open Field Test was used to investigate anxiety and depression levels. Inflammatory factors and anti-oxidant activity were also evaluated in isolated hippocampus and cerebral cortex. MPH treated groups (10 and 20 mg/kg) demonstrated anxiety and depression like behavior in OFT. MPH significantly increased lipid peroxidation, GSSG level, IL-1β and TNF-α in isolated tissues. In addition, MPH at the same doses (10 and 20 mg/kg) reduced GSH, superoxide dismutase, glutathione peroxidase and glutathione reductase activity significantly in hippocampus and cerebral cortex. In conclusion, acute administration of high doses of MPH can cause oxidative and inflammatory changes in brain cells and induce neurodegeneration in hippocampus and cerebral cortex of adult rats.
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In rats, methylphenidate administration has been reported to produce neuroinflammation and oxidative stress in the hippocampus and cerebral cortex, as measured by the inflammatory markers tumor necrosis factor α and interleukin 1β.
“In rats, MPH administration has been reported to produce neuroinflammation and oxidative stress in the hippocampus and cerebral cortex, as measured by the inflammatory markers tumor necrosis factor α and interleukin 1β (264, 265).”
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Kuczenski, R., & Segal, D. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07264.2002 · Cited by 316 · see citing works
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Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder
Corona, J. C. (2020) · Antioxidants · doi:10.3390/antiox9111039 · Cited by 163 · see citing works
- Authors
- Motaghinejad, M., Motevalian, M., Shabab, B., & Fatima, S.
- Affiliations
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Motevalian, Manijeh
- Venue
- Journal of Neural Transmission
- Published
- 2016-09-28
- Volume
- 124
- Issue
- 1
- Pages
- 121-131
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2525986321
- Cited by
- 46
- References
- 1
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 5
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Iran University of Medical Sciences
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- methylphenidate, neurodegeneration, hippocampus, cerebral cortex, oxidative stress, neuroinflammation, anxiety-like behavior, depression-like behavior, lipid peroxidation, glutathione, superoxide dismutase, glutathione peroxidase, glutathione reductase, IL-1β, TNF-α, acute drug administration
- MeSH terms
- Animals, Anxiety, Cerebral Cortex, Depression, Dose-Response Relationship, Drug, Hippocampus, Inflammation, Male, Methylphenidate, Mitochondria, Motor Activity, Random Allocation, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Neurodegenerative Diseases
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