Interventions for the prevention and treatment of postpartum psychosis: a systematic review
Abstract
Postpartum psychosis is a serious disorder that can cause negative consequences for the mother, infant, and entire family. While reports of this condition date back for centuries, little is known about what interventions are most effective for this population. The purpose of this systematic review was to examine the research evidence on interventions for the prevention and treatment of postpartum psychosis. Studies were searched using CINAHL, EMBASE, MEDLINE, PsycINFO, and PubMed databases. All primary research studies published in English since 1970 that explored interventions for the prevention or treatment of postpartum psychosis were included. The search resulted in 26 studies on interventions for postpartum psychosis, with 10 focusing on prevention and 17 focusing on treatment. Studies on the prevention of postpartum psychosis have examined the effects of mood stabilizers, antipsychotics, and hormone therapy, while those examining treatment have included electroconvulsive therapy, mood stabilizers, antipsychotics, hormones, and the beta blocker propranolol. Only preliminary evidence suggests which interventions may be effective strategies to prevent (e.g., lithium) and treat (e.g., electroconvulsive therapy) postpartum psychosis. Due to methodological limitations in the studies reviewed, extensive evidence-based recommendations for the prevention and treatment of postpartum psychosis cannot be made. The known risk factors and negative consequences of postpartum psychosis…
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The use of oestrogens in prevention of postpartum psychosis is controversial.
“The use of oestrogens is controversial”
From Maternal Postpartum Psychosis: A Case of Infanticide (2025) · cites this paper as [16]
Divalproate was not shown to be beneficial in the prevention of postpartum psychosis.
“divalproate was not shown to be beneficial in the prevention of postpartum psychosis.”
From Maternal Postpartum Psychosis: A Case of Infanticide (2025) · cites this paper as [16]
Progesterone is reported to be of no benefit in prevention of postpartum psychosis.
“progesterone is reported to be of no benefit whatsoever [16].”
From Maternal Postpartum Psychosis: A Case of Infanticide (2025) · cites this paper as [16]
In one study, olanzapine was reported to be beneficial for prevention of postpartum psychosis.
“In one study, olanzapine was reported to be beneficial.”
From Maternal Postpartum Psychosis: A Case of Infanticide (2025) · cites this paper as [16]
Cites
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Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period
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Self-citationPostpartum psychiatric disorders
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Self-citationPostpartum Psychosis: Madness, Mania, and Melancholia in Motherhood
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Maternal Postpartum Psychosis: A Case of Infanticide
Rharbaoui, H., Boubekri, M., Bencharfa, Z., & Omari, F. E. (2025) · Scholars Journal of Medical Case Reports · doi:10.36347/sjmcr.2025.v13i05.007 · Cited by 1 · see citing works
- Authors
- Doucet, S., Jones, I., Letourneau, N., Dennis, C.-L., & Blackmore, E. R.
- Affiliations
- University of New Brunswick (CA)
- Cardiff University (GB)
- University of Toronto (CA)
- University of Rochester Medicine (US)
- Corresponding author
- Doucet, Shelley
- Venue
- Archives of Women's Mental Health
- Published
- 2010-12-03
- Volume
- 14
- Issue
- 2
- Pages
- 89-98
- ISSN
- 1434-1816 (ISSN-L)
- 1435-1102
- OpenAlex
- W2042725016
- Cited by
- 103
- References
- 4
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 7 · 2014: 12 · 2013: 7 · 2012: 9
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Women s Mental Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- postpartum psychosis, prevention, treatment, mood stabilizers, antipsychotic drugs, hormone therapy, lithium, electroconvulsive therapy, propranolol, postpartum depression, maternal mental health
- MeSH terms
- Female, Humans, Psychotic Disorders, Postpartum Period
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