Bone mineral density and turnover in patients with acromegaly in relation to sex, disease activity, and gonadal function
Abstract
Acromegaly is a rare disease caused by growth hormone (GH) hypersecretion. GH and insulin-like growth factor-I (IGF-I) exert anabolic activity in bones. Nevertheless, bone mineral density (BMD) loss is not uncommon in patients with acromegaly. It is assumed to be due to hypogonadism associated with the acromegaly. The aim of the study was to examine BMD at various skeletal sites and bone turnover and to assess the influence of impaired gonadal function and disease activity on BMD and turnover changes in acromegaly. A total of 62 patients were studied (40 women, 22 men). Among the women, 22 had active disease and 18 were cured; 16 women had normal gonadal function, and 24 were hypogonadal. Altogether, 12 men presented with active acromegaly, and 10 were cured; normal gonadal function was found in 10 men, and hypogonadism was diagnosed in 12 men. Controls were 30 healthy subjects. Densitometry using dual-energy X-ray absorptiometry of the lumbar spine, proximal femur, forearm, and total body was carried out. Bone turnover was studied based on serum osteocalcin, C-terminal collagen type 1 crosslinks, and bone alkaline phosphatase concentration. A disadvantageous effect of acromegaly on bone density was associated with hypogonadism in the distal radius (in women), the proximal femur (in men), and the total body (both sexes). An anabolic effect of GH during active acromegaly was present in the proximal femur only in men. We confirmed increased bone turnover in the presence of acro…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations in acromegaly than in controls.
“Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations than in controls [28, 29, 35, 40, 43].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [43]
Osteocalcin, a specific marker of bone formation, is elevated in subjects with active acromegaly.
“A specific marker of bone formation, osteocalcin, is elevated in subjects with active disease [28, 29, 35, 40, 43].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [43]
The citation lists haven’t been fetched yet
References 25 · Cited by 74
- Authors
- Bolanowski, M., Daroszewski, J., Mędraś, M., & Zadrożna-Śliwka, B.
- Affiliations
- Wroclaw Medical University (PL)
- Corresponding author
- Bolanowski, Marek
- Venue
- Journal of Bone and Mineral Metabolism
- Published
- 2005-12-27
- Volume
- 24
- Issue
- 1
- Pages
- 72-78
- ISSN
- 0914-8779 (ISSN-L)
- 1435-5604
- OpenAlex
- W2005618591
- Cited by
- 74
- References
- 25
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Bone and Mineral Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- acromegaly, bone mineral density, bone turnover, hypogonadism, gonadal function, growth hormone, insulin-like growth factor I, sex differences, disease activity, osteocalcin, C-terminal telopeptide, bone-specific alkaline phosphatase, proximal femur, distal radius, bone loss
- MeSH terms
- Acromegaly, Adult, Aged, Alkaline Phosphatase, Female, Gonads, Humans, Hypogonadism, Insulin-Like Growth Factor I, Male, Middle Aged, Absorptiometry, Photon, Bone Density, Osteocalcin, Bone Remodeling, Human Growth Hormone, Collagen Type I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
