Bone mineral density and bone microarchitecture after long-term suppressive levothyroxine treatment of differentiated thyroid carcinoma in young adult patients
Abstract
Bone mineral density (BMD) seems not to be decreased in young patients given long-term suppressive doses of levothyroxine (LT4), but information regarding the bone microstructure in these patients is lacking. The aim of this study was to determine whether supraphysiologic doses of LT4, initiated during childhood or adolescence for treatment of differentiated thyroid carcinoma (DTC), have any detrimental effects on bone microarchitecture as evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Seventeen patients (27.3 ± 7.1 years old) with DTC with subclinical hyperthyroidism since adolescence and 34 healthy volunteers matched for age, sex, and body mass index were studied by dual-energy X-ray absorptiometry (DXA) to determine the areal BMD at the lumbar spine, hip, and proximal third of the radius. Volumetric BMD and structural parameters of the trabecular and cortical bone were assessed by HR-pQCT of the distal radius and distal tibia. DTC patients were given suppressive doses of LT4 starting at a mean age of 12.6 years, and the mean duration of treatment was 14.2 years. In DTC patients, clinical parameters did not correlate with DXA or HR-pQCT parameters. No differences were found between the patients and controls with respect to BMD and Z scores at any site evaluated by DXA, and no differences were found in the bone microstructure parameters evaluated by HR-pQCT. This cross-sectional study suggests that long-standing suppressive therapy with L…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a young patient cohort with average age 27.3 years, no differences in bone mineral density and bone parameters were found despite TSH suppression for 14.2 years after thyroidectomy.
“Interestingly, a study conducted in a young patient cohort (average 27.3 years old) found no differences in BMD and bone parameters despite TSH suppression for 14.2 years after thyroidectomy (23).”
From Effect of TSH Suppression Therapy on Bone Mineral Density in Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis (2021) · cites this paper as [23]
The citation lists haven’t been fetched yet
References 22 · Cited by 34
- Authors
- Mendonça Monteiro de Barros, G., Madeira, M., Vieira Neto, L., de Paula Paranhos Neto, F., Carvalho Mendonça, L. M., Corrêa Barbosa Lima, I., Corbo, R., & Fleiuss Farias, M. L.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Corresponding author
- Madeira, Miguel
- Venue
- Journal of Bone and Mineral Metabolism
- Published
- 2015-06-09
- Volume
- 34
- Issue
- 4
- Pages
- 417-421
- ISSN
- 0914-8779 (ISSN-L)
- 1435-5604
- OpenAlex
- W1515759865
- Cited by
- 34
- References
- 22
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Bone and Mineral Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- bone mineral density, bone microarchitecture, levothyroxine, differentiated thyroid cancer, subclinical hyperthyroidism, peak bone mass, trabecular bone, cortical bone, young adult patient, long-term hormone therapy
- MeSH terms
- Adolescent, Adult, Brazil, Cross-Sectional Studies, Humans, Middle Aged, Radius, Thyroid Neoplasms, Thyroxine, Bone Density, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
