Long-acting medications for the hyperkinetic disorders: A systematic review and European treatment guideline
Open accessAbstract
A systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorder is reported, giving effect sizes and numbers-to-treat for extended-release stimulant preparations and atomoxetine (ATX). A panel of experts from several European countries used the review to make recommendations about the use of these drugs in practice, and conclusions are reported: (1) Long-acting preparations should be available and used; (2) They should not replace short-acting drugs (which will be the initial treatment for many children for reasons of cost and flexibility of dosing). Individual clinical choice is needed. (3) Both ATX and extended-release preparations of stimulants should be available. The choice will depend upon the circumstances, and detailed recommendations are made.
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References 66 · Cited by 375
- Authors
- Banaschewski, T., Coghill, D., Santosh, P., Zuddas, A., Asherson, P., Buitelaar, J., Danckaerts, M., Döpfner, M., Faraone, S. V., Rothenberger, A., Sergeant, J., Steinhausen, H.-C., Sonuga-Barke, E. J. S., & Taylor, E.
- Affiliations
- University of Göttingen (DE)
- University of Dundee (GB)
- Great Ormond Street Hospital (GB)
- University of Cagliari (IT)
- King's College London (GB)
- Radboud University Nijmegen (NL)
- Universitair Ziekenhuis Leuven (BE)
- University of Cologne (DE)
- SUNY Upstate Medical University (US)
- Vrije Universiteit Amsterdam (NL)
- University of Zurich (CH)
- University of Southampton (GB)
- Corresponding author
- Banaschewski, Tobias
- ORCID
- Venue
- European Child & Adolescent Psychiatry
- Published
- 2006-05-05
- Volume
- 15
- Issue
- 8
- Pages
- 476-495
- ISSN
- 1018-8827 (ISSN-L)
- 1435-165X
- OpenAlex
- W2101805186
- Semantic Scholar
- a2d8ddcdfa740e4438f760d99c3733f18da0cdb5
- Cited by
- 375
- References
- 66
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 10 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 18 · 2016: 22 · 2015: 27 · 2014: 37 · 2013: 37 · 2012: 35
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- green
- research.vu.nl
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- European Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- ePrints Soton (University of Southampton) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- GRO (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- attention deficit hyperactivity disorder, hyperkinetic disorder, atomoxetine, treatment guidelines, children, effect size
- MeSH terms
- Atomoxetine Hydrochloride, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Delayed-Action Preparations, Europe, Humans, Propylamines
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