Melatonin in children with autistic spectrum disorders: recent and practical data
Open accessAbstract
Over the last 20 years, melatonin, a pineal hormone synthesized from serotonin, has been implicated in various studies on the autism spectrum disorder (ASD) and altered melatonin levels were detected in subgroups of subjects with ASD. Its effect on sleep disturbances got the attention of clinicians and several investigations were carried out to determine the usefulness and safety of melatonin administration in this disorder. Hypotheses were also raised regarding the possibility that the dysfunctional synthesis and secretion of melatonin detected in subgroups of subjects with ASD may increase the risk as well the severity of ASD. The purpose of this paper is to review our pharmacokinetic knowledge on melatonin and present results from recent studies on sleep disorders in autism, their treatment with melatonin and the impact of melatonin prescription in children with ASD evaluated in a Diagnostic Center for Autism Spectrum Disorder in Paris, France.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies have found considerable variation in melatonin product concentrations and ingredients.
“Studies have found considerable variation in product concentrations and ingredients [64, 65].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [64]
The citation lists haven’t been fetched yet
References 41 · Cited by 54
- Authors
- Doyen, C., Mighiu, D., Kaye, K., Colineaux, C., Beaumanoir, C., Mouraeff, Y., Rieu, C., Paubel, P., & Contejean, Y.
- Affiliations
- Centre Hospitalier Sainte-Anne (FR)
- Corresponding author
- Doyen, C.
- ORCID
- Venue
- European Child & Adolescent Psychiatry
- Published
- 2011-02-26
- Volume
- 20
- Issue
- 5
- Pages
- 231-239
- ISSN
- 1018-8827 (ISSN-L)
- 1435-165X
- OpenAlex
- W2014135473
- Cited by
- 54
- References
- 41
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 7 · 2012: 4
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- European Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- melatonin, autism spectrum disorder, sleep disorders, melatonin supplementation, children, pineal hormone, autism severity
- MeSH terms
- Child, Child Development Disorders, Pervasive, Humans, Melatonin, Sleep Wake Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
