Evaluation of antioxidative/oxidative status and prolidase parameters in cases of inguinal hernia with joint hypermobility syndrome
Abstract
Purpose Most previous reports have shown that the basic mechanism of inguinal hernia involves insufficient collagen strength and metabolism. The aim of this study was to evaluate whether joint hypermobility is involved in the development of inguinal hernia in children and to investigate oxidative stress parameters and prolidase activity in tissue samples from children with inguinal hernia. Methods This cross-sectional study involving 41 patients (age, 6.36 ± 2.96 years) with inguinal hernia treated in the pediatric surgery department of our institution and 40 age- and sex-matched controls (age, 6.02 ± 3.13 years) was performed from May to December 2011. Joint hypermobility was assessed using the Beighton criteria in all patients. Hernia sacs were analyzed with respect to the total antioxidative/oxidative status and prolidase activity. The patients were divided into two groups (inguinal hernia with and without hypermobility) according to a Beighton score cut-off of ≥6. Results A total of 81 subjects aged 3-10 years participated. The ratio of joint hypermobility was significantly higher in patients than in controls (p = 0.01). The prolidase activity, total oxidant status, and oxidative stress index were higher in tissue samples from patients with joint hypermobility (p Conclusions Our results show that joint hypermobility syndrome is associated with inguinal hernia in children and that increased prolidase activity and oxidative stress in tissue samples from patients with joint…
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A recent case control study in 3-10-year-old children presenting with inguinal hernia found a statistically significantly higher proportion of patients with GJH at Beighton score ≥ 6/9 compared to age and sex matched controls.
“A recent case control study in 3–10-year-old children presenting with inguinal hernia found a statistically significantly higher proportion of patients with GJH at Beighton score ≥ 6/9 in children compared to age and sex matched controls [18].”
From Pediatric joint hypermobility: a diagnostic framework and narrative review (2023) · cites this paper as [18]
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Clinch, J., Deere, K., Sayers, A., Palmer, S., Riddoch, C., Tobias, J. H., & Clark, E. M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30435 · Cited by 195 · see citing works
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Pediatric joint hypermobility: a diagnostic framework and narrative review
Tofts, L. J., Simmonds, J., Schwartz, S. B., Richheimer, R. M., O’Connor, C., Elias, E., Engelbert, R., Cleary, K., Tinkle, B. T., Kline, A. D., et al. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02717-2 · Cited by 74 · see citing works
- Authors
- Cevik, M., Yazgan, P., & Aksoy, N.
- Affiliations
- Harran University (TR)
- ORCID
- Venue
- Hernia
- Published
- 2014-02-25
- Volume
- 18
- Issue
- 6
- Pages
- 849-853
- ISSN
- 1248-9204 (ISSN-L)
- 1265-4906
- OpenAlex
- W2043782760
- Cited by
- 9
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Hernia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Health Sciences › Medicine › Surgery › Hip disorders and treatments
- Keywords
- inguinal hernia, joint hypermobility syndrome, prolidase, oxidative stress, antioxidant status, collagen metabolism, pediatric hernia, Beighton score
- MeSH terms
- Antioxidants, Child, Collagen, Cross-Sectional Studies, Dipeptidases, Ehlers-Danlos Syndrome, Female, Hernia, Inguinal, Humans, Infant, Joint Instability, Male, Peritoneum, Oxidants, Oxidative Stress
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