Efficacy of intravenous alendronate for the treatment of glucocorticoid-induced osteoporosis in children with autoimmune diseases
Abstract
Our objective was to investigate the efficacy of intravenous alendronate for the treatment of glucocorticoid-induced osteoporosis (GIOP) in children with autoimmune diseases. Five children with autoimmune disease and GIOP were treated with 5 mg intravenous alendronate once every 3 months. After 1 and 2 years, we evaluated the changes in the Z score of the femoral neck bone mineral density (BMD), serum bone alkaline phosphatase, and urinary deoxypyridinoline. Six patients with GIOP, whose BMD could be observed over a 1-year period without alendronate treatment, were defined as controls. After 1 and 2 years of treatment, intravenous treatment significantly inhibited bone loss. The efficacy of alendronate demonstrated a significant correlation with a high level of bone turnover markers before alendronate treatment. Intravenous alendronate is considered to be a good choice for the treatment of GIOP because of its excellent efficacy. In addition, our study suggests that the efficacy of alendronate depends on the bone turnover of patients before treatment. Intervention with bisphosphonates during periods of high bone turnover may be recommended.
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In clinical practice, both bisphosphonates and PTH increase spine BMD to a greater extent than hip BMD.
“In clinical practice, both bisphosphonates and PTH increase the spine BMD to a greater extent than the hip BMD [12, 14, 47, 50-53].”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [14]
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References 26 · Cited by 34
- Authors
- Inoue, Y., Shimojo, N., Suzuki, S., Arima, T., Tomiita, M., Minagawa, M., & Kohno, Y.
- Affiliations
- Chiba University (JP)
- Corresponding author
- Inoue, Yuzaburo
- Venue
- Clinical Rheumatology
- Published
- 2008-03-11
- Volume
- 27
- Issue
- 7
- Pages
- 909-912
- ISSN
- 0770-3198 (ISSN-L)
- 1434-9949
- OpenAlex
- W1998752290
- Cited by
- 34
- References
- 26
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 3 · 2017: 1 · 2015: 4 · 2014: 1 · 2012: 5
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- glucocorticoid-induced osteoporosis, bisphosphonates, pediatric autoimmune disease, bone mineral density, femoral neck, bone turnover markers, deoxypyridinoline, alkaline phosphatase, bone loss prevention
- MeSH terms
- Child, Female, Glucocorticoids, Humans, Infusions, Intravenous, Longitudinal Studies, Male, Osteoporosis, Pilot Projects, Rheumatic Diseases, Bone Density, Bone Remodeling, Antirheumatic Agents, Alendronate, Bone Density Conservation Agents
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