Structural analysis and prebiotic activity of exopolysaccharide produced by probiotic strain Bifidobacterium bifidum EPS DA-LAIM
Open accessAbstract
Exopolysaccharide (EPS)-producing Bifidobacterium bifidum EPS DA-LAIM was isolated from healthy human feces, the structure of purified EPS from the strain was analyzed, and its prebiotic activity was evaluated. The EPS from B. bifidum EPS DA-LAIM is a glucomannan-type heteropolysaccharide with a molecular weight of 407-1007 kDa, and its structure comprises 2-mannosyl, 6-mannosyl, and 2,6-mannosyl residues. The purified EPS promoted the growth of representative lactic acid bacteria and bifidobacterial strains. Bifidobacterium bifidum EPS DA-LAIM increased nitric oxide production in RAW 264.7 macrophage cells, indicating its immunostimulatory activity. Bifidobacterium bifidum EPS DA-LAIM also exhibited high gastrointestinal tract tolerance, gut adhesion ability, and antioxidant activity. These results suggest that EPS from B. bifidum EPS DA-LAIM is a potentially useful prebiotic material, and B. bifidum EPS DA-LAIM could be applied as a probiotic candidate.Supplementary information The online version contains supplementary material available at 10.1007/s10068-022-01213-w.
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The main mechanisms of action of probiotics include advancement of the epithelial barrier, increased adhesion to the intestinal mucosa, production of antibacterial substances, competitive exclusion of pathogens, simultaneous suppression of bacterial adhesion, and modulation of the immune system.
“According to data in the literature, the advancement of the epithelial barrier, increased adhesion to the intestinal mucosa, production of antibacterial substances, competitive exclusion of pathogens, simultaneous suppression of bacterial adhesion, and modulation of the immune system are some of the main mechanisms of action of probiotics [87,88,89,90,91] (Figure 1).”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [87]
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References 34 · Cited by 31
- Authors
- Kang, M. J., Jeong, H., Kim, S., Shin, J., Song, Y., Lee, B.-H., Park, H.-G., Lee, T.-H., Jiang, H.-H., Han, Y.-S., Lee, B.-G., Lee, H.-J., Park, M.-J., & Park, Y.-S.
- Affiliations
- Gachon University (KR)
- Dong-A Pharmaceutical (South Korea) (KR)
- Corresponding author
- Park, Young-Seo
- Venue
- Food Science and Biotechnology
- Published
- 2022-12-01
- Volume
- 32
- Issue
- 4
- Pages
- 517-529
- ISSN
- 1226-7708 (ISSN-L)
- 2092-6456
- PMC
- PMC9992680
- OpenAlex
- W4310526467
- Cited by
- 31
- References
- 34
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 8 · 2023: 4 · 2022: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Food Science and Biotechnology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- Bifidobacterium bifidum, exopolysaccharides, prebiotic activity, glucomannan, heteropolysaccharide structure, lactic acid bacteria growth, immune enhancement, nitric oxide production, gastrointestinal tolerance, antioxidant activity, probiotic candidate
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