Circulating irisin and chemerin levels as predictors of seizure control in children with idiopathic epilepsy
Abstract
Irisin and chemerin peptides expression are triggered by hypoxia and involved in activation of inflammatory cascades in various organs including the brain; however, their role in epilepsy is not fully illustrated. This study aims to explore the predictive role of irisin and chemerin for seizure control in children with idiopathic epilepsy. This cross-sectional comparative study included 50 children with idiopathic epilepsy; 25 of them had controlled seizures over the previous 6 months and 30 age- and sex-matched healthy children as controls. Epilepsy characteristics, seizure severity Chalfont score, and response to medications were assessed in relation to serum irisin and chemerin levels. In comparison to healthy controls, serum chemerin and irisin levels were significantly higher in children with idiopathic epilepsy especially those with uncontrolled seizures. Serum chemerin and irisin levels had significant positive correlation with seizure severity Chalfont score and the duration of epilepsy. Elevated Chalfont score (OR 3.19), serum chemerin (OR 2.01), and irisin (OR 2.03) are predictors of uncontrolled seizures. Circulating chemerin and irisin have 80% and 76% sensitivity and 88% and 92% specificity at cutoff point > 191.38 ng/ml and > 151.2 ng/ml respectively for prediction of uncontrolled seizures in children with idiopathic epilepsy. Elevated circulating level of irisin and chemerin may predict poor seizure control in children with idiopathic epilepsy suggesting the ro…
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RARRES2 has chemotactic properties during inflammatory responses, and serum RARRES2 levels were associated with severity of seizures in children with idiopathic epilepsy.
“RARRES2 (retinoic acid receptor responder protein 2, also known as chemerin) is described as having chemotactic properties during inflammatory responses and serum RARRES2 levels were associated with severity of seizures in children with idiopathic epilepsy (Elhady et al, 2018).”
From The genetic regulation of protein expression in cerebrospinal fluid (2023) · cites this paper as Elhady et al, 2018
Cites
Neurobehavioral comorbidities of epilepsy: Role of inflammation
Mazarati, A. M., Lewis, M. L., & Pittman, Q. J. (2017) · Epilepsia · doi:10.1111/epi.13786 · Cited by 96 · see citing works
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The genetic regulation of protein expression in cerebrospinal fluid
Hansson, O., Kumar, A., Janelidze, S., Stomrud, E., Insel, P. S., Blennow, K., Zetterberg, H., Fauman, E., Hedman, Å. K., Nagle, M. W., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216359 · Cited by 56 · see citing works
- Authors
- Elhady, M., Youness, E. R., Gafar, H. S., Abdel Aziz, A., & Mostafa, R. S. I.
- Affiliations
- Al-Azhar University (EG)
- National Research Centre (EG)
- Corresponding author
- Elhady, Marwa
- Venue
- Neurological Sciences
- Published
- 2018-06-02
- Volume
- 39
- Issue
- 8
- Pages
- 1453-1458
- ISSN
- 1590-1874 (ISSN-L)
- 1590-3478
- OpenAlex
- W2806429553
- Cited by
- 19
- References
- 1
- Citations by year
- 2024: 5 · 2023: 1 · 2022: 7 · 2021: 5 · 2018: 1
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- irisin, chemerin, idiopathic epilepsy, pediatric epilepsy, seizure control, uncontrolled seizures, serum biomarkers, hypoxia, neuroinflammation, seizure severity, epilepsy duration
- MeSH terms
- Analysis of Variance, Child, Child, Preschool, Cross-Sectional Studies, Electroencephalography, Epilepsy, Female, Fibronectins, Humans, Male, Predictive Value of Tests, Regression Analysis, Retrospective Studies, ROC Curve, Severity of Illness Index, Case-Control Studies, Chemokines, Intercellular Signaling Peptides and Proteins
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