Gut microbiota and colorectal cancer
Open accessAbstract
The gut microbiota is considered as a forgotten organ in human health and disease. It maintains gut homeostasis by various complex mechanisms. However, disruption of the gut microbiota has been confirmed to be related to gastrointestinal diseases such as colorectal cancer, as well as remote organs in many studies. Colorectal cancer is a multi-factorial and multi-stage involved disorder. The role for microorganisms that initiate and facilitate the process of colorectal cancer has become clear. The candidate pathogens have been identified by culture and next sequencing technology. Persuasive models have also been proposed to illustrate the complicated and dynamic time and spatial change in the carcinogenesis. Related key molecules have also been investigated to demonstrate the pathways crucial for the development of colorectal cancer. In addition, risk factors that contribute to the tumorigenesis can also be modulated to decrease the susceptibility for certain population. In addition, the results of basic studies have also translated to clinical application, which displayed a critical value for the diagnosis and therapy of colorectal cancer. In this review, we not only emphasize the exploration of the mechanisms, but also potential clinical practice implication in this microbiota era.
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The consequence of F. nucleatum invasion is the promotion of NF-κB signaling and the expression of several cytokines, such as IL-6, IL-8, IL-10, IL-18 and TNF-α.
“The consequence of this invasion is the promotion of NF-κB signaling and the expression of several cytokines, such as IL-6, IL-8, IL-10, IL-18 and TNF-α.”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [150]
The net result of these changes is the creation of a pro-inflammatory milieu for tumor growth, favored by the FapA-mediated suppression of T cells' cytotoxic activity.
“The net result of these changes is the creation of a pro-inflammatory milieu for tumor growth, favored by the FapA-mediated suppression of T cells’ cytotoxic activity[147,150].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [150]
F. nucleatum has two adhesion proteins, FapA and FadA, the latter of which mediates the invasion of the bacterium into the intestinal epithelium.
“This microorganism has two adhesion proteins, FapA and FadA, the latter of which mediates the invasion of the bacterium into the intestinal epithelium.”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [150]
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References 128 · Cited by 205
- Authors
- Gao, R., Gao, Z., Huang, L., & Qin, H.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Qin, H.
- Venue
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2017-01-07
- Volume
- 36
- Issue
- 5
- Pages
- 757-769
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- PMC
- PMC5395603
- OpenAlex
- W2569903275
- Cited by
- 205
- References
- 128
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 19 · 2023: 23 · 2022: 28 · 2021: 27 · 2020: 29 · 2019: 21 · 2018: 22 · 2017: 12
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (No.81230057; No.81472262)
- Emerging cutting-edge technology joint research projects of Shanghai (No.SHDC12012106)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- gut microbiota, colorectal cancer, intestinal homeostasis, carcinogenesis, microbiota-based therapy, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Risk Factors, Colorectal Neoplasms, Models, Animal, Gastrointestinal Tract, Dysbiosis
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