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Cited by 17Bacterial Infections and VaccinesSepsis Diagnosis and TreatmentInfectious Encephalopathies and Encephalitis

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Eosinopenia as a marker of diagnosis and prognostic to distinguish bacterial from aseptic meningitis in pediatrics

Debray, Agathe, Nathanson, Sylvie, Moulin, Florence, Salomon, Jérome, Davido, Benjamin·2019·European Journal of Clinical Microbiology & Infectious Diseases
DOI 10.1007/s10096-019-03614-y
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Abstract

Procalcitonin (PCT) has proven its efficacy to distinguish bacterial from aseptic meningitis in children. Nevertheless, its use in routine is limited by its cost and availability, especially in low- and middle-income countries. It is now acknowledged that eosinopenia is a marker of infection and/or severity of the systemic inflammatory response. Although no study ever demonstrated that eosinopenia could differentiate bacterial from viral infection, we decided to conduct a study concerning meningitis in children. This bicentric and retrospective study was conducted between January 2012 and October 2018, in children hospitalized for meningitis. The white blood cell was systematically gathered at the admission to evaluate the eosinophil count. Characteristic data were compared between 2 groups: documented bacterial meningitis (DBP) and aseptic meningitis which includes documented viral meningitis (DVM) and non-documented meningitis (ND). Among 190 patients admitted for meningitis, 151 were analyzed, including DBM (n = 45), DVM (n = 73), and ND (n = 33) meningitis. Groups were comparable. Mean age was 33 ± 48 months with a sex ratio of 1.6. Mean of eosinophil count was 15 ± 34/mm 3 in the DBM group versus 132 ± 167/mm 3 for the aseptic meningitis group (p < 0.0001). Best threshold for the diagnosis of bacterial meningitis was an eosinophil count < 5/mm 3 with a sensitivity of 80% and specificity of 73% and a likelihood ratio of 2.9. Eosinopenia seems to be a reliable and non-invasive marker of bacterial meningitis in pediatrics. The absence of extra cost makes it very interesting in low- and middle-income countries or when usual biomarkers such as PCT are unavailable.

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Crossref · 10.1007/s10096-019-03614-y

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Research works printed but not linked: 1

  1. Zappert J (1893) Ueber das Vorkommen der Eosinophilen Zellen in menschlichen Blute. Z Klin Med 23:227–308

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Metadata

Authors
Debray, A., Nathanson, S., Moulin, F., Salomon, J., & Davido, B.
Affiliations
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Hôpital André Mignot (FR)
  • Hôpital Necker-Enfants Malades (FR)
Corresponding author
Davido, Benjamin
ORCID
Venue
European Journal of Clinical Microbiology & Infectious Diseases
Publisher
Springer Science and Business Media LLC
Published
2019-06-22
Volume
38
Issue
10
Pages
1821-1827
ISSN
  • 0934-9723 (ISSN-L)
  • 1435-4373
DOI
10.1007/s10096-019-03614-y
OpenAlex
W2951789820
Cited by
17
References
37
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 8
FWCI
2.20
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords
eosinopenia, bacterial meningitis, aseptic meningitis, viral meningitis, pediatric meningitis, eosinophil count, diagnostic biomarkers, low- and middle-income countries, white blood cell count
MeSH terms
Adolescent, Child, Child, Preschool, Diagnosis, Differential, Eosinophils, Female, Humans, Infant, Infant, Newborn, Leukopenia, Male, Meningitis, Aseptic, Retrospective Studies, Sensitivity and Specificity, Meningitis, Bacterial

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