The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
PD-1/PD-L1 blockade in cancer treatment: perspectives and issues
Open accessAbstract
Recent studies showed that tumor cells 'edit' host immunity in several ways to evade immune defenses in the tumor microenvironment. This phenomenon is called "cancer immune escape." One of the most important components in this system is an immunosuppressive co-signal (immune checkpoint) mediated by the PD-1 receptor and its ligand, PD-L1. PD-1 is mainly expressed on activated T cells, whereas PD-L1 is expressed on several types of tumor cells. Preclinical studies have shown that inhibition of the interaction between PD-1 and PD-L1 enhances the T-cell response and mediates antitumor activity. Several clinical trials of PD-1/PD-L1 signal-blockade agents have exhibited dramatic antitumor efficacy in patients with certain types of solid or hematological malignancies. In this review, we highlight recent clinical trials using anti-PD-1 or anti-PD-L1 antibodies against several types of malignancies, including a trial conducted in our department, and describe the clinical perspectives and issues regarding the PD-1/PD-L1 blockade in cancer treatment.
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Citations
Cites
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“On the basis of these findings, guidelines and specific algorithms for identification, early intervention, and management of irAEs have been developed [20, 25].”
BackgroundInfluentialMutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
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Cited by
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy
Liu, J., Chen, Z., Li, Y., Zhao, W., Wu, J., & Zhang, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.731798 · Cited by 417
Xu, L., Zhang, Y., Tian, K., Chen, X., Zhang, R., Mu, X., Wu, Y., Wang, D., Wang, S., Liu, F., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0929-6 · Cited by 177
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Metadata
- Authors
- Hamanishi, J., Mandai, M., Matsumura, N., Abiko, K., Baba, T., & Konishi, I.
- Venue
- International Journal of Clinical Oncology
- Published
- 2016-02-22
- Volume
- 21
- Issue
- 3
- Pages
- 462-473
- ISSN
- 1341-9625 (ISSN-L)
- 1437-7772
- OpenAlex
- W2277129094
- Cited by
- 351
- References
- 83
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hamanishi, J., Mandai, M., Matsumura, N., Abiko, K., Baba, T., & Konishi, I. (2016). PD-1/PD-L1 blockade in cancer treatment: perspectives and issues. International Journal of Clinical Oncology. https://doi.org/10.1007/s10147-016-0959-z
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
