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Use of α1-microglobulin for diagnosing chronic interstitial nephropathy
Abstract
α1-Microglobulin (α1M) is a low molecular weight protein and has been best characterized for detecting acute lesions of proximal tubules (Bonventre in Contrib Nephrol 156:213-219, 2007). This study has tried to evaluate the use of α1M for the differential diagnosis of chronic interstitial nephropathy. 145 patients were recruited [81 men and 64 women, mean age 61.8 ± 16.7 years, 64.8 % have an estimated glomerular filtration (GFR) <60 ml/min]. Urinary α1M was evaluated using an immunonephelometric assay. 82 patients were diagnosed as having chronic interstitial nephritis (CIN), and 46 patients have been previously diagnosed of glomerulonephritis (GN). A group of hypertensive patients without renal disease was used as control (n = 17). Patients in GN group had the highest α1M excretion (15.05 mg/24 h). When the α1M/albuminuria rates were calculated, the CIN group had the highest rate (1.03 mg/mg) and the GN group had the lowest rate (0.04 mg/mg) (p < 0.001). When the α1M/proteinuria rates were calculated, the results were rather similar. The AUC for CIN group was 0.785, and the one for GN group was 0.139. Patients with estimated GFR <60 ml/min showed a higher excretion of α1M (18.75, 8.75-40.00 mg/24 h). Nevertheless, α1M/albuminuria and α1M/proteinuria rates were still higher in CIN patients with GFR ≥60 ml/min. α1M urinary excretion is increased in chronic interstitial nephropathy and glomerulonephritis as well as in patients with GFR <60 ml/min. The α1M/albuminuria rate and the α1M/proteinuria quotient are increased in chronic interstitial nephropathies but decreased in glomerular diseases.
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“The delay in finding the exact cause can lead to interstitial fibrosis and chronic kidney disease (CKD) [1, 3, 11, 13, 18, 19]”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [19]
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Cited by
Muhammad, A., Zhang, Y., Huang, L., Yuan, Q., Wang, W., Pu, J., Lin, W., Tang, R., & Xiao, X. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae054 · Cited by 13
“The delay in identifying the precise culprit agent can impede therapeutic measures, ultimately leading to renal fibrosis and CKD [1 ,3 ,11 ,13 ,18 ,19 ].”
Background
Metadata
- Authors
- Robles, N. R., Lopez-Gomez, J., Garcia-Pino, G., Ferreira, F., Alvarado, R., Sanchez-Casado, E., & Cubero, J. J.
- Affiliations
- Government of Extremadura (ES)
- Venue
- Clinical and Experimental Medicine
- Published
- 2013-06-21
- Volume
- 14
- Issue
- 3
- Pages
- 315-320
- ISSN
- 1591-8890 (ISSN-L)
- 1591-9528
- OpenAlex
- W2069025229
- Cited by
- 11
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical and Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- alpha1-microglobulin, chronic interstitial nephritis, glomerulonephritis, differential diagnosis, urinary biomarkers, albuminuria, proteinuria, estimated glomerular filtration rate, proximal tubule injury, immunonephelometry
- MeSH terms
- Adult, Aged, Alpha-Globulins, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Nephelometry and Turbidimetry, Nephritis, Interstitial, Urine, Biomarkers
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